1462-52-8Relevant academic research and scientific papers
Thiophospholipid compound and production method thereof
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Paragraph 0039-0044, (2019/10/29)
The invention discloses a thiophospholipid compound and a production method thereof. The production method of the sulfurphospholipid compound comprises the following production steps of (1) dissolving10-12 mmol of 1-n-olefin and 10 mmol of 1-mercapto-n-alkanoic acid in a solvent dichloromethane, adding 0.05-0.5 mmol of 2,2,-dimethoxy-2-phenylacetophenone to initiate a click reaction, and after the reaction is completed, conducting separation and purification by means of silica gel column chromatography to obtain thioalkanoic acid; and (2) dissolving the thioalkanoic acid product in dichloromethane, adding N,N'-carbonyldiimidazole for activation for 0.5-4 hours, adding a mixed dimethylsulfoxide solution of 1,8-diazabicyclo[5.4.0]undec-7-ene and glycerophosphoryl choline, and after a reaction is completed, conducting separation and purification to obtain a white solid product thioalkanoic acid glycerophosphoryl choline. The structure of the provided thiophospholipid compound contains thioether bonds which are easy to oxidize, so that the thiophospholipid compound is subjected to fast oxidation modification in an oxidant, and has better hydrophilicity.
An improved method for cysteine alkylation
Perrey, David A.,Uckun, Fatih M.
, p. 1859 - 1861 (2007/10/03)
An improved method for the synthesis of S-alkylated cysteine derivatives with branched alkyl chains is reported. These compounds can be obtained in good yield and high purity by refluxing the cysteine thiol with the appropriate alkyl bromide in a solution of sodium ethoxide in ethanol.
Sufrace-Active Properties and Thermal Behavior of S-Alkylthio-Carboxylic Acids and Their Potassium Salts
Kamio, Katsuhisa,Kamata, Kohro,Mima, Seiji,Kuroda, Toshiharu,Ookawara, Hiroshi,et al.
, p. 805 - 810 (2007/10/02)
S-Alkylthiocarboxylic acids and their potassium salts were prepared by photoaddition of α-olefins (C10, C12, and C14) with mercapto carboxylic acids such as thiomalic acid, triopropionic acid, and thioglycolic acid.The physicochemical solution properties and thermal stabilities for three series of thiosurfactants were evaluated.S-Alkylthiocarboxylic acids that contain bridged S-bonds provide excellent thermally stable surfactants, and their alkaline salts exhibit good surface activity.KEY WORDS: α-Olefin, mercapto carboxylic acid, photoaddition, S-alkylthiocarboxylic acid, S-alkylthioglycolic acid, S-alkylthiomalic acid, S-alkylthiopropionic acid, surface activity, thermal stability.
Thioesters and antioxidant compositions containing the same
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, (2008/06/13)
The present invention relates to thioesters having the structural formula: STR1 wherein Rx is selected from the group of formulae consisting of: STR2 R1, R2 and R3 are independently selected from the group of radicals consisting of hydrogen or methyl; R4 and R5 are independently selected from the group of radicals consisting of hydrogen, alkyls having 1 to 18 carbon atoms, aryls having 6 to 10 carbon atoms, aralkyls having 7 to 9 carbon atoms, and radicals of the formula: STR3 and R6 is selected from the group of radials consisting of alkyls having 1 to 24 carbon atoms, aryls having 6 to 12 carbon atoms and aralkyls having 7 to 12 carbon atoms. These thioesters are particularly useful as a synergist for conventional phenolic and amine antioxidants.
Stabilizer for polyolefin resin
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, (2008/06/13)
A new process for preparing a polyhydric alcohol 3-alkylthiopropionate polyolefin resin stabilizer is provided, comprising the steps of heating at 40°-160° C. an alpha-olefin having 6 to 28 carbon atoms with betamercaptopropionic acid or a lower alkyl betamercaptopropionate in the presence of an organic peroxide or azonitrile reaction initiator, esterifying the resulting 3-alkylthiopropionic acid or ester with pentaerythritol or tris(2-hydroxyethyl) cyanurate, and recovering the polyhydric alcohol 3-alkylthiopropionate polyolefin resin stabilizer from the mixture. Polyolefin resin compositions stabilized with the stabilizer prepared by the process of this invention, and stabilizer compositions comprising the stabilizer prepared by the process of this invention together with a phenol and/or an alkaline earth metal salt of a monocarboxylic acid are also provided.
