73535-73-6

Usage

Uses

Used in Pharmaceutical Industry:
2-(6-CHLORO-3-PYRIDAZINYL)-2-PHENYLACETONITRILE is used as a building block for the synthesis of pharmaceuticals, due to its potential to contribute to the development of new drugs with unique therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(6-CHLORO-3-PYRIDAZINYL)-2-PHENYLACETONITRILE is utilized as a component in the creation of agrochemicals, potentially enhancing crop protection and yield through its incorporation into various formulations.
Used in Organic Chemistry Research:
2-(6-CHLORO-3-PYRIDAZINYL)-2-PHENYLACETONITRILE serves as an intermediate in the manufacture of other organic compounds, facilitating the synthesis of a range of chemical products with diverse applications.
Used in Chemical Research:
2-(6-CHLORO-3-PYRIDAZINYL)-2-PHENYLACETONITRILE is also used in chemical research as a subject of study for its unique structure and properties, contributing to the understanding of nitrile compounds' behavior and reactivity.

InChI:InChI=1/C12H8ClN3/c13-12-7-6-11(15-16-12)10(8-14)9-4-2-1-3-5-9/h1-7,10H/t10-/m0/s1

Upstream product

• 141-30-0 3,6-dichlorpyridazine 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 153757-96-1 (6-methoxy-pyridazin-3-yl)-phenyl-methanone 
• 147849-85-2 6‐benzylpyridazin‐3(2H)‐one 
• 338753-08-5 2‐(6‐oxo‐1,6‐dihydropyridazin‐3‐yl)‐2‐phenylacetonitrile 
• 209412-02-2 2-phenyl-2-[6-(phenylthio)pyridazin-3-yl]acetonitrile 
• 1159497-81-0 C₁₂H₁₀ClN₃S 
• 1159497-55-8 2-[6-(4-benzylpiperidin-1-yl)pyridazin-3-yl]-2-(phenyl)acetonitrile 
• 1001044-65-0 2-phenyl-2-[6-(4-phenylpiperazin-1-yl)pyridazin-3-yl]acetonitrile 
• 717876-14-7 C₁₆H₁₆N₄O 
• 1159497-54-7 2-phenyl-2-[6-(pyrrolidin-1-yl)pyridazin-3-yl]acetonitrile 
• 60905-93-3 3-benzyl-pyridazine 
• 60906-52-7 phenyl (3-pyridazinyl) ketone 
• 146233-32-1 3-(6-chloropyridazinyl) phenyl ketone 
• 66978-44-7 2-phenyl-2-(6-mercapto-3-pyridazinyl)-thioacetamide 
• 66978-40-3 α-phenyl-α-(pyridazin-3-yl)-acetonitrile 

Relevant academic research and scientific papers

Synthesis and biological screening of some novel 6-substituted 2-alkylpyridazin-3(2H)-ones as anti-inflammatory and analgesic agents

Some novel derivatives of 2-alkyl 6-substituted pyridazin-3(2H)-ones were synthesized by condensation of 3,6-dichloropyridazine with the sodium salt of benzyl cyanide, followed by hydrolysis and coupling with alkyl halides. The synthesized compounds were

Histone deacetylase inhibitor taking pyridazinone as mother nucleus structure, and preparation method and applications thereof

The invention discloses a histone deacetylase inhibitor taking pyridazinone as a mother nucleus structure, and a preparation method and applications thereof. The structure of the inhibitor is shown asa formula I; and the compound shown as the formula I has good histone deacetylase inhibitory activity and anti-tumor cell proliferation effects, and can be used for treating cancers. The structure ofthe inhibitor is shown as the formula I.

The discovery of VX-745: A novel and selective p38α kinase inhibitor

The synthesis of novel, selective, orally active 2,5-disubstituted 6H-pyrimido[1,6-b]pyridazin-6-one p38α inhibitors is described. Application of structural information from enzyme-ligand complexes guided the selection of screening compounds, leading to t

Synthesis, fungicidal and antibacterial activity of new pyridazine derivatives

Compounds 1-3 were obtained in the reaction of 3,6-dichloro-pyridazines with phenylacetonitriles in the biphasic system - DMSO/50% NaOH. The chlorine atom was replaced with cycloalkylamino (4-13) and hydrazinyl (23, 24) moiety. These last compounds were condensed with aldehydes (25-34). Pyridazynylphenylacetonitriles were converted into amides 14-18 and thioamides 19-22. In compounds 2, 3 the chlorine atom was replaced with thiophenyl (37, 38) and in compound 1 with thioethyl and thiophenyl (35, 36) functional groups. In the reactions of compounds 1, 2 with ammonium polysulfide thioamides with thiol group (39, 40) and chlorine atom (41, 42) were obtained. Compounds 1-17, 19-43 were screened for antibacterial and fungicidal activities.

Synthesis of a new scaffold: The 7H,8H-pyrimido[1,6-b]pyridazin-6,8-dione nucleus

This paper describes a modified method of preparation of a number of α-aryl-α-(pyridazin-3-yl)-acetonitriles via the C-arylation reaction of the corresponding carbanions of phenylacetonitriles using 3-chloropyridazine derivatives. KOH and DMSO were used i

Efficient large-scale preparation of phenyl 3-pyridazinyl ketone

A convenient approach to phenyl 3-pyridazinyl ketone 4 permitting economical large scale preparation is proposed. Commercially available 3,6-dichloropyridazine 1 serves as the starting material in the three-step process.

Preparation of Heteroaryl Phenylmethanes and a 13C and 15N NMR Spectroscopic Study of their Conjugate Carbanions. Rotational Isomerism and Charge Maps of the Anions and Ranking of the Charge Demands of the Heterocycles

2-Benzylpyridazine, 4-benzylpyrimidine, 2-benzylpyrimidine and 2-benzylpyrazine, (5-8) have been prepared in order to study their 13C and 15N spectra and those of their conjugate carbanions (1-4).These systems are aza-homologues of the previously reported

Novel thioamide derivatives containing a pyridazine group

Novel pyridazine-containing thioamide derivatives of the formula STR1 wherein R1 is STR2 wherein A is hydrogen, methyl, phenyl or mercapto, and B is hydrogen or phenyl; R2 is hydrogen or methyl; R3 is hydrogen, methyl or p