1463-21-4

Basic information

• Product Name: N-TFA-L-VALINE METHYL ESTER
• Synonyms: N-TFA-L-VALINE METHYL ESTER;N-Trifluoroacetyl-L-valine methyl ester
• CAS NO: 1463-21-4
• Molecular Formula: C₈H₁₂F₃NO₃
• Molecular Weight: 227.18
• Mol File: 1463-21-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-TFA-L-VALINE METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: N-TFA-L-VALINE METHYL ESTER(1463-21-4)
• EPA Substance Registry System: N-TFA-L-VALINE METHYL ESTER(1463-21-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1463-21-4(Hazardous Substances Data)

Upstream product

• 431-47-0 trifluoroacetic acid-methyl ester 
• 67-56-1 methanol 
• 1447695-69-3 cycloforskamide 
• 407-25-0 trifluoroacetic anhydride 
• 72-18-4 L-valine 
• 34241-42-4 sodium (S)-valinate 
• 66866-64-6 (4S)-4-isopropyl-5-oxo-1,3-oxazolidine-3-carboxylic acid benzyl ester 
• 24210-19-3 methyl (2S)-3-methyl-[(benzyloxy)carbonylamino]butanoate 
• 886207-25-6 2,2,2-trifluoro-N-[2-methyl-1-(2-thioxo-oxazolidine-3-carbonyl)-propyl]-acetamide 
• 4070-48-8 L-Valine methyl ester 
• 6306-52-1 L-valine methylester hydrochloride 

Downstream Products

• 850733-77-6 (3'R,4S)-3-(1'-oxo-3'-mercapto-3'-phenylpropyl)-4-isopropyl-5,5-dimethyl-1,3-oxazolidinone 
• 877377-55-4 N-cinnamoyl-4S-isopropyl-5,5-dimethyloxazolidinethione 
• 597558-53-7 (S)-4-isopropyl-5,5-dimethyl-1,3-oxazolidine-2-thione 
• 163453-95-0 (S)-3-amino-2,4-dimethylpentan-2-ol 
• 2996-11-4 N-trifluoroacetyl-L-valine-(N'-trityl-hydrazide) 

Relevant articles and documents

Nyuzenamides A and B: Bicyclic Peptides with Antifungal and Cytotoxic Activity from a Marine-Derived Streptomyces sp.

Two bicyclic peptides, nyuzenamides A (1) and B (2), were discovered from Streptomyces isolated from suspended matter in deep sea water collected in the Sea of Japan. Their structures were determined through nuclear magnetic resonance and mass spectrometry analyses in combination with X-ray crystallography and the chiral-phase gas chromatography-mass spectrometry method to comprise ten amino acid residues containing four unusual amino acids along with aromatic acyl units. Both compounds displayed antifungal activity against pathogenic fungi and cytotoxicity against P388 murine leukemia cells.

Design, synthesis, and applications of potential substitutes of t-Bu-phosphinooxazoline in Pd-catalyzed asymmetric transformations and their use for the improvement of the enantioselectivity in the Pd-catalyzed allylation reaction of fluorinated allyl enol carbonates

The design, synthesis, and applications of potential substitutes of t-Bu-PHOX in asymmetric catalysis is reported. The design relies on the incorporation of geminal substituents at C5 in combination with a substituent at C4 other than t-butyl (i-Pr, i-Bu, or s-Bu). Most of these new members of the PHOX ligand family behave similarly in terms of stereoinduction to t-Bu-PHOX in three palladium-catalyzed asymmetric transformations. Electronically modified ligands were also prepared and used to improve the enantioselectivity in the Pd-catalyzed allylation reaction of fluorinated allyl enol carbonates.

Mild regeneration of the carboxylic group of amino acid alkyl esters by aqueous methanolic sodium hydrogen carbonate via 5-oxazolidinones

A simple racemization-free procedure allows the regeneration of the carboxylic acid group of amino acid alkyl esters by way of an intermediate 5-oxazolidinone which is hydrolyzed by treatment with sodium hydrogen carbonate in aqueous methanol.