146337-23-7

Basic information

• Product Name: 1-Boc-3-Methoxypiperidine
• Synonyms: 1-Boc-3-Methoxypiperidine;tert-butyl 3-Methoxypiperidine-1-carboxylate;1-Boc-3-Methoxypiperidin;3-Methoxypiperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 146337-23-7
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.28934
• EINECS: -0
• Mol File: 146337-23-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 274.094°C at 760 mmHg
• Flash Point: 119.568°C
• Appearance: /
• Density: 1.03g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.471
• PKA: -2.40±0.40(Predicted)
• CAS DataBase Reference: 1-Boc-3-Methoxypiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-Methoxypiperidine(146337-23-7)
• EPA Substance Registry System: 1-Boc-3-Methoxypiperidine(146337-23-7)

Safety Data

• Hazardous Substances Data: 146337-23-7(Hazardous Substances Data)

Usage

General Description

1-Boc-3-Methoxypiperidine, also known as 1-(tert-butoxycarbonyl)-3-methoxypiperidine, is a chemical compound used in organic synthesis and pharmaceutical research. It is a piperidine derivative with a tert-butoxycarbonyl (Boc) protecting group attached to the nitrogen atom and a methoxy group attached to the third carbon atom. 1-Boc-3-Methoxypiperidine is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has potential application as a precursor in the production of drugs targeting central nervous system disorders and as a reagent in medicinal chemistry. 1-Boc-3-Methoxypiperidine is a valuable intermediate in the development of new drugs and is widely utilized in organic chemistry research.

InChI:InChI=1/C11H21NO3/c1-11(2,3)15-10(13)12-7-5-6-9(8-12)14-4/h9H,5-8H2,1-4H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 85275-45-2 N-tert-butoxycarbonyl-3-piperidinol 
• 74-88-4 methyl iodide 

Downstream Products

• 4045-29-8 (+/-)-3-methoxypiperidine 
• 259133-72-7 (2R,6R)-2-Phenoxythiocarbonyloxymethyl-6-propyl-piperidine-1-carboxylic acid tert-butyl ester 
• 134441-93-3 tert-butyl (2S)-2-(hydroxymethyl)piperidine-1-carboxylate 
• 26250-84-0 (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid 
• 150521-32-7 (S)-1-N-Boc-piperidine-2-al 
• 131667-57-7 tert-butyl 1,2,3,4-tetrahydro-1-pyridinecarboxylate 

Relevant articles and documents

2-Aminophenylpyrimidines as Novel Inhibitors of Aminoacyl-tRNA Synthetase Interacting Multifunctional Protein 2 (AIMP2)-DX2 for Lung Cancer Treatment

Aminoacyl-tRNA synthetase interacting multifunctional proteins (AIMPs) have recently been considered novel therapeutic targets in several cancers. In this publication we report the development of novel 2-aminophenylpyrimidines as new AIMP2-DX2 inhibitors.

RENIN INHIBITORS

The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

PYRAZOLE DERIVATIVE

A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.