146397-21-9Relevant academic research and scientific papers
Bioorthogonally Applicable Fluorogenic Cyanine-Tetrazines for No-Wash Super-Resolution Imaging
Knorr, Gergely,Kozma, Eszter,Schaart, Judith M.,Németh, Krisztina,T?r?k, Gy?rgy,Kele, Péter
, p. 1312 - 1318 (2018)
The synthesis, fluorogenic characterization, and labeling application of four tetrazine-quenched cyanine probes with emission maxima in the red-far red range is reported. Fluorescence of the cyanine-cores is quenched via through-bond-energy-transfer (TBET) exerted by a bioorthogonal tetrazine unit. Upon bioorthogonal labeling reaction with cyclooctyne tagged proteins, the quenching effect ceases, and thus the fluorescence reinstates, resulting in an increase in fluorescence intensity. As a rare example among indocyanines, one of our new probes was found suitable in STED-based super-resolution imaging. The applicability of this fluorogenic Tet-Cy3 probe was therefore further demonstrated in the bioorthogonal labeling of cytoskeletal protein, actin, with subsequent super-resolution microscopy (STED) imaging even under no-wash conditions.
New indodicarbocyanine dyes for the biological microchip technology
Kuznetsova,Vasiliskov,Antonova,Mikhailovich,Zasedatelev,Chudinov
, p. 130 - 133 (2008)
New indodicarbocyanine dyes with the carboxybutyl group in position-3 of the indolenine fragment bearing methyl and sulfonic groups in positions 5 and 7 of the cycle were synthesized in order to find the most effective fluorescent labels for the biologica
NOVEL CYANINE COMPOUND FOR LABELING BIOMOLECULE AND PREPARATION METHOD THEREOF
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Paragraph 0169-0172, (2018/04/18)
The present invention refers to biomolecule marker has a cyanine compound and number to the next formula 1 bath method are disclosed. [Formula 1] Another test, R1 , R2 , R3 , R4 , B, m and n each specification defines efined. (by machine translation)
NOVEL CYANINE COMPOUND FOR LABELING BIOMOLECULE AND PREPARATION METHOD THEREOF
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Paragraph 0169-0172, (2017/09/14)
The present invention relates to a novel cyanine compound which is represented by chemical formula 1, and is used for biomolecular labeling. The present invention further relates to a production method thereof. In the chemical formula 1, R_1, R_2, R_3, R_4, B, m, and n are the same as defined in the present specification.COPYRIGHT KIPO 2017
Imaging agents useful for brain and prepration method thereof
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Paragraph 0103; 0202-0204, (2017/08/02)
The present invention relates to a fluorescent dye for brain imaging, which is represented by the following [Chemical Formula 1]. [Chemical Formula 1] In the [Chemical Formula 1], R_1, R_2, R_3, R_4, R_5, and n are as defined in the specification.(AA) Example 1(BB) Example 3(CC) Example 4(DD) Example 5COPYRIGHT KIPO 2017
NOVEL CYANINE COMPOUND FOR LABELING BIOMOLECULE AND PREPARATION METHOD THEREOF
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Paragraph 0169-0172, (2017/05/02)
The present invention relates to a novel cyanine compound represented by chemical formula 1 for labeling a biomolecule, and to a preparation method thereof. In chemical formula 1, each of R_1, R_2, R_3, R_4, B, m, and n is the same as defined in the specification. The cyanine compound has high stability, and thus can be easily stored for a long period of time. Also, the cyanine compound does not generate byproducts after a biomolecule forms a bond with a pigment, and thus does not require a subsidiary purification process.
Cyanine compound for labeling biomolecule and preparation method thereof
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, (2014/05/25)
Disclosed are a novel cyanine compound, represented by the following Formula 1, for labeling biomolecules, and a method for preparing the same. wherein R1, R2, R3, R4, B, m and n are defined as above.
Water-soluble cyanine dyes for biological microchip technology
Kuznetsova,Luk'yanova,Vasiliskov,Kharitonova,Chudinov,Zasedatelev
experimental part, p. 2438 - 2442 (2009/02/05)
Novel indodicarbocyanine dyes were obtained and their spectroscopic characteristics were determined. For equal concentrations of the dyes, the relative fluorescence efficiency was measured at the excitation wavelengths λ = 635 and 655 nm and the emission
Novel asymmetric indodicarbocyanine dyes
Kuznetsova,Davydov,Vasiliskov,Stomakhin,Chudinov,Zasedatelev
, p. 2263 - 2267 (2008/09/18)
Novel indodicarbocyanine dyes functionalized at position 5 of the indolenine system were obtained and characterized by spectroscopic methods.
