1464-12-6Relevant articles and documents
General synthesis of β-alanine-containing spider polyamine toxins and discovery of Nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors
Lucas, Simon,Poulsen, Mette H.,N?rager, Niels G.,Barslund, Anne F.,Bach, Tinna B.,Kristensen, Anders S.,Str?mgaard, Kristian
, p. 10297 - 10301 (2012)
Certain spiders contain large pools of polyamine toxins, which are putative pharmacological tools awaiting further discovery. Here we present a general synthesis strategy for this class of toxins and prepare five structurally varied polyamine toxins. Elec
Characterization and synthesis of a new calcium antagonist from the venom of a fishing spider
McCormick, Kevin D.,Kobayashi, Kazumi,Goldin, Stanley M.,Laxma Reddy,Meinwald, Jerrold
, p. 11155 - 11168 (2007/10/02)
A new calcium antagonist, CNS 2103, is isolated from the venom of a fishing spider, Dolomedes okefinokensis. The structure of this compound is derived from spectroscopic data, including tandem mass spectrometry. A flexible, convergent synthesis of CNS 2103 is described.