146406-75-9

Basic information

• Product Name: 4',4''''-(1,4-PHENYLENE)BIS(2,2':6',2''-TERPYRIDINE)
• Synonyms: 4',4''''-(1,4-PHENYLENE)BIS(2,2':6',2''-TERPYRIDINE);1,4-Bis(2,2':6',2''-terpyridin-4'-yl)benzene;4`,4````-(1,4-Phenylene)bis(2,2`:6`,2``-terpyridine),96%;1,4-Di([2,2':6',2''-terpyridin]-4'-yl)benzene;2,2':6',2''-Terpyridine, 4',4''''-(1,4-phenylene)bis-;1,4-bis(4'-phenyl-2,2':6',2''-terpyridin-4'-yl)benzene;1,4-bis[2,2':6',2''-terpyridine-4'-yl]benzene
• CAS NO: 146406-75-9
• Molecular Formula: C₃₆H₂₄N₆
• Molecular Weight: 540.62
• Product Categories: Heterocyclic Compounds;C9 to C46;Heterocyclic Building Blocks;Pyridines
• Mol File: 146406-75-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 340 °C (dec.)(lit.)
• Boiling Point: 727.8°Cat760mmHg
• Flash Point: 403.7°C
• Appearance: /
• Density: 1.227g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.73±0.22(Predicted)
• CAS DataBase Reference: 4',4''''-(1,4-PHENYLENE)BIS(2,2':6',2''-TERPYRIDINE)(CAS DataBase Reference)
• NIST Chemistry Reference: 4',4''''-(1,4-PHENYLENE)BIS(2,2':6',2''-TERPYRIDINE)(146406-75-9)
• EPA Substance Registry System: 4',4''''-(1,4-PHENYLENE)BIS(2,2':6',2''-TERPYRIDINE)(146406-75-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 146406-75-9(Hazardous Substances Data)

Usage

General Description

4',4''''-(1,4-phenylene)bis(2,2':6',2''-terpyridine) is a chemical compound that consists of a central 1,4-phenylene group connected to two 2,2':6',2''-terpyridine moieties. 4',4''''-(1,4-PHENYLENE)BIS(2,2':6',2''-TERPYRIDINE) is known for its complex structure and its potential applications in coordination chemistry and the development of functional materials. It is often used as a ligand for the formation of coordination complexes with various metal ions, and its unique three-dimensional structure allows for the formation of intricate supramolecular assemblies. The compound has also been studied for its potential use in the development of optoelectronic devices and sensors due to its interesting electronic and photophysical properties. Overall, 4',4''''-(1,4-phenylene)bis(2,2':6',2''-terpyridine) is a versatile chemical compound with promising applications in various fields of chemistry and materials science.

Synthetic route

2-acetylpyridine (1122-62-9) + terephthalaldehyde, (623-27-8) → 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9)

Conditions	Yield
With ammonium hydroxide; potassium tert-butylate In ethanol for 20h; Inert atmosphere;	77%
With ammonium hydroxide; sodium hydroxide In ethanol; water at 25℃; for 10h;	62%
With ammonium hydroxide; potassium hydroxide In water for 48h; Reflux;	50%
With potassium hydroxide; ammonium hydroxide In methanol for 48h; Heating;	39%
With ammonium hydroxide; potassium hydroxide In ethanol at 60℃; for 24h; Inert atmosphere;

1,4-bis<1,5-dioxo-1,5-bis(2-pyridyl)pentan-3-yl>benzene → 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9)

Conditions	Yield
With ammonium acetate In ethanol for 120h; Reflux;	72%
With ammonium acetate In ethanol for 120h; Heating;	39%
With ammonium hydroxide In various solvent(s) at 100℃; for 2h;

methyl (4-pyridyl) ketone (1122-54-9) + terephthalaldehyde, (623-27-8) → 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9)

Conditions	Yield
Stage #1: methyl (4-pyridyl) ketone; terephthalaldehyde, With ammonia; sodium hydroxide In ethanol; water at 0℃; for 1h; Stage #2: In ethanol; water at 80℃; for 24h;	55%

3-[4-(3-oxo-3-pyridin-2-yl-propenyl)-phenyl]-1-pyridin-2-yl-propenone (210306-18-6) + 2-acetylpyridine pyridinium hexafluorophosphate → 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9)

Conditions	Yield
With ammonium acetate

2-acetylpyridine (1122-62-9) → 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: NaOH / various solvent(s) / 2 h / 0 °C 2: aq. NH3 / various solvent(s) / 2 h / 100 °C View Scheme
Multi-step reaction with 2 steps 1: 46 percent / 3percent aq. KOH / ethanol / 2 h 2: NH4(OAc) View Scheme
Multi-step reaction with 2 steps 1: 64 percent / aq. NaOH / ethanol / 8 h / Ambient temperature 2: 39 percent / ammonium acetate / ethanol / 120 h / Heating View Scheme
Multi-step reaction with 3 steps 1: potassium hydroxide / methanol; water / 48 h / 20 °C 2: potassium hydroxide / ethanol; water / Reflux 3: ammonium acetate / ethanol / 120 h / Reflux View Scheme

terephthalaldehyde, (623-27-8) → 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: NaOH / various solvent(s) / 2 h / 0 °C 2: aq. NH3 / various solvent(s) / 2 h / 100 °C View Scheme
Multi-step reaction with 2 steps 1: 46 percent / 3percent aq. KOH / ethanol / 2 h 2: NH4(OAc) View Scheme
Multi-step reaction with 2 steps 1: 64 percent / aq. NaOH / ethanol / 8 h / Ambient temperature 2: 39 percent / ammonium acetate / ethanol / 120 h / Heating View Scheme
Multi-step reaction with 3 steps 1: potassium hydroxide / methanol; water / 48 h / 20 °C 2: potassium hydroxide / ethanol; water / Reflux 3: ammonium acetate / ethanol / 120 h / Reflux View Scheme

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + bis(pentamethylcyclopentadienyl)ytterbium * Et2O → [(C5Me5)2Yb](1,4-bis(2,2':6',2''-terpyridin-4'-yl)benzene)[Yb(C5Me5)2]

Conditions	Yield
In toluene under Ar or He; room temp. toluene soln. of Yb complex (2 equiv.) added to solid ligand with stirring; solvent removed under vac.; elem. anal.;	99%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + [(η5-indenyl)(triphenylphosphine)(acetonitrile)ruthenium(II)] hexafluorophosphate (241152-08-9) → [((η5-indenyl)Ru(PPh3))2(1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene)]PF6

Conditions	Yield
In benzene Ru complex was refluxed with ligand in benzene for 4 h; concd. (vac.); Et2O added; filtered; washed (methanol; Et2O);	90%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + [(η5-pentamethylcyclopentadienyl)(triphenylphosphine)(acetonitrile)ruthenium(II)] hexafluorophosphate (529499-17-0) → [((C5Me5)Ru(PPh3))2(1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene)]PF6

Conditions	Yield
In benzene Ru complex was refluxed with ligand in benzene for 4 h; concd. (vac.); Et2O added; filtered; washed (methanol; Et2O);	90%

ammonium hexafluorophosphate + 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + Ru(C15H11N3)((C15H10N3)2C6H4RuCl3)(2+)*2PF6(1-)*5H2O=[Ru(C15H11N3)((C15H10N3)2C6H4)RuCl3](PF6)2*5H2O → {Ru(C5H3N(C5H4N)2)}2{C5H2N(C5H4N)2}2C6H4(4+)*4PF6(1-)={{Ru(C5H3N(C5H4N)2)}2{C5H2N(C5H4N)2}2C6H4}{PF6}4

Conditions	Yield
In methanol Ar-atmosphere; refluxing Ru-complex with slight excess of ligand for 18 h, cooling, filtration (celite), treatment with excess NH4PF6 (pptn.); filtration, drying; elem. anal.;	82%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + copper(ll) sulfate pentahydrate + water (7732-18-5) → [Zn2(1,4-bis(2,2':6',2''-terpyridine-4-yl)benzene)(SO4)2]*2H2O

Conditions	Yield
In water High Pressure; under hydrothermal conditions, in Parr acid digestion bomb; mixt. of Cu salt, ligand and H2O (molar ratio 1.7:1:340) heated at 200°C for 98 h; crystals isolated;	80%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + cobalt(II) chloride hexahydrate + N,N-dimethyl-formamide (68-12-2, 33513-42-7) → [(CoCl2)2(μ-(1,4-bis[(2,2′:6',2"-terpyridyl)-4'-yl]benzene))]*4(dimethylformamide)

Conditions	Yield
at 160℃; for 72h; Autoclave;	80%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + bromopentacarbonylmanganese(I) (14516-54-2) → C42H24Br2Mn2N6O6

Conditions	Yield
In acetone for 15h; Inert atmosphere; Reflux;	78%

potassium hexafluorophosphate (17084-13-8) + 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + [trichloro(4'-tolyl-2,2':6',2''-terpyridine)ruthenium(III)] (136276-24-9) → (4'-p-tolyl-2,2':6',2''-terpyridin)(1,4-bis(2,2':6',2''-terpyridin-4'-yl)benzene)ruthenium(II) hexafluorophosphate

Conditions

Yield

With AgBF4 In N,N-dimethyl-formamide; acetone; acetonitrile byproducts: AgCl; mixt. Ru-complex and AgBF4 refluxed in acetone (2h, in air), mixt. filtered (removal of AgCl), addn. DMF, evapn. acetone, soln. slowly added tohot soln. (80°C) of the terpyridine/DMF, mixt. refluxed (1 h, under Ar), evapn., addn. KPF6 and CH3CN; addn. water (pptn.), evapn. of CH3CN, ppt. washed (1. water (twice), 2.ethr (twice)), column chromy. (silica gel, acetonitrile);

77%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + silver trifluoromethanesulfonate (2923-28-6) → C36H24N6*2Ag(1+)*2CF3O3S(1-)

Conditions	Yield
In methanol at 20℃; for 16h; Inert atmosphere; Darkness;	76%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + [Pt(C6F4CF3)2(S(C2H5)2)2] (198560-46-2) → [(Pt(C6F4CF3)2)2C36H24N6] (217639-52-6)

Conditions	Yield
In not given (N2); elem. anal.;	73%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + manganese(II) chloride tetrahydrate → C36H28Cl4Mn2N6O2*2H2O

Conditions	Yield
In water at 119.84℃; for 24h; Autoclave;	73%

ammonium hexafluorophosphate + 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + [trichloro(4'-tolyl-2,2':6',2''-terpyridine)ruthenium(III)] (136276-24-9) → (4'-p-tolyl-2,2':6',2''-terpyridin)(1,4-bis(2,2':6',2''-terpyridin-4'-yl)benzene)ruthenium(II) hexafluorophosphate

Conditions	Yield
With silver tetrafluoroborate In N,N-dimethyl-formamide byproducts: AgCl; Ru and Ag compds. refluxed in acetone for 3 h, filtered, concd. (vac.), DMF added, acetone removed, soln. added to a soln. of ligand (1.5 equiv)at 80°C, refluxed (Ar, 2 h), cooled, added to a soln. of NH4PF6 (H2O); ppt. filtered, washed (H2O, diethyl ether), solvent removed (vac.), chromy. (alumina, CH3CN/KNO3/H2O/N(C2H5)3), repptd. (NH4PF6); elem. anal.;	70%
With silver tetrafluoroborate In N,N-dimethyl-formamide; acetone Ru-complex was reacted with AgBF4 in acetone, refluxed for 3 h, ligand in DMF was added, refluxed for 2 h under Ar, aq. NH4PF6 was added; column chromy. on alumina with MeCN/satd. KNO3/H2O;	70%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + zinc(II) nitrate hexahydrate + water (7732-18-5) → μ-1,4-bis(2,2’:6’,2’’-terpyridin-4’-yl)benzene-κ3N1,N2,N6:κ3N3,N4,N5-bis[(diformato-κO)-zinc(II)] dihydrate

Conditions	Yield
In N,N-dimethyl-formamide at 160℃; for 72h; Autoclave;	66.3%

sodium tetrafluoroborate (13755-29-8) + 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer → (C5(CH3)5RhCl)2((C5H4N)2C5H2N(C6H4)C5H2N(C5H4N)2)(2+)*2BF4(1-)=[(C5(CH3)5RhCl)2((C5H4N)2C5H2N(C6H4)C5H2N(C5H4N)2)](BF4)2

Conditions	Yield
In methanol stirring (4 h); evapn., dichloromethane addn.; elem. anal.;	60%

potassium hexafluorophosphate (17084-13-8) + 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + (2,4-bis(2-pyridyl)-6-p-bromophenyl-1,3,5-triazine)RuCl3 (879495-64-4) → [(2,4-bis(2-pyridyl)-6-p-bromophenyl-1,3,5-triazine)Ru(1,4-bis(2,2':6',2''-terpyridin-4'-yl)benzene)Ru(2,4-bis(2-pyridyl)-6-p-bromophenyl-1,3,5-triazine)](PF6)4*KPF6

Conditions	Yield
In N,N-dimethyl-formamide suspn. Ru complex and ligand in DMF was refluxed for 1 h, react. mixt. was cooled, KPF6 was added; ppt. was filtered, soln. was evapd., dissolved in MeCN and treated with aq. KPF6, ppt. was filtered, dissolved in MeCN and chromd. on silica (MeCN-aq.KNO3 9:1), aq. KPF6 was added, ppt. was dissolved in MeCN and pptd. with water; elem. anal.;	50%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + zinc(II) nitrate hexahydrate + water (7732-18-5) + N,N-dimethyl-formamide (68-12-2, 33513-42-7) → di-μ-oxido-bis{μ-1,4-bis(2,2’:6’,2’’-terpyridin-4’-yl)benzene κ3N1,N2,N6:κ3N3,N4,N5-bis[(formato-κO)-zinc(II)]} monodimethylformamide hexahydrate

Conditions	Yield
at 160℃; for 72h; Autoclave;	43.9%

ammonium hexafluorophosphate + 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + ruthenium(III) chloride trihydrate → bis(1,4-bis(2,2':6',2''-terpyridin-4'-yl)benzene)ruthenium(II) hexafluorophosphate

Conditions	Yield
In N,N-dimethyl-formamide a soln. of ligand (slight excess) added to a soln. of Ru compd., refluxed under Ar for 24 h, cooled, added to a soln. of NH4PF6 (H2O); chromy. (alumina, CH3CN/satd.KNO3/H2O/N(C2H5)3); elem. anal.;	40%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + (trimethylplatinum(IV) iodide)4 → [(PtI(CH3)3)2C36H24N6] (217639-55-9)

Conditions	Yield
In not given (N2); elem. anal.;	36%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + rhenium(I) pentacarbonyl bromide (14220-21-4) → [(ReBr(CO)3)2C36H24N6] (217639-53-7)

Conditions	Yield
In not given (N2); elem. anal.;	35%

ammonium hexafluorophosphate + 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + (Ru(C15H10N3)2)2(C6H4)2((C15H11N3)RuCl3)(4+)*4PF6(1-)*9H2O=[(Ru(C15H10N3)2)2(C6H4)2((C15H11N3)RuCl3)](PF6)4*9H2O → (Ru(C15H10N3)2C6H4)3(C15H11N3)(6+)*6PF6(1-)=[(Ru(C15H10N3)2C6H4)3(C15H11N3)](PF6)6

Conditions	Yield
In methanol Ar-atmosphere; refluxing Ru-complex with slight excess of ligand for 18 h, cooling, filtration (celite), treatment with excess NH4PF6 (pptn.); filtration, drying; elem. anal.;	33%

ammonium hexafluorophosphate + 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + [4'-(p-tolyl)-2, 2':6',2''-terpyridine]osmium trichloride (124643-10-3) → [(4,4''''-(1,4-phenylene)bis(2,2':6',2''-terpyridine))Os(4'-tolyl-2,2':6',2''-terpyridine)][PF6]2 + [(4'-tolyl-2,2':6',2''-terpyridine)Os(4,4''''-(1,4-phenylene)bis(2,2':6',2''-terpyridine))Os(4'-tolyl-2,2':6',2''-terpyridine)][PF6]4

Conditions

Yield

In ethylene glycol under N2; a soln. of a ligand (0.81 mmol) and Os-contg. compd. (0.403 mmol) in ethylene glycol was stirred at reflux for 1 h; the mixt. was cooled to room temp.; excess aq. NH4PF6 was added; the ppt. was filtered off, washed with H2O and diethyl ether, and re-dissolved in CH3CN; the filtrate was evapd. and the residue was dried in vac.; column chromy. on silica with CH3CN-aq. KNO3;

A 30% B 22%

potassium hexafluorophosphate (17084-13-8) + 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + (4'-(p-bromophenyl)-2,2':6',2''-terpyridine)RuCl3 (586400-18-2) → [(4'-(p-bromophenyl)-2,2':6',2''-terpyridine)Ru(1,4-bis(2,2':6',2''-terpyridin-4'-yl)benzene)Ru(4'-(p-bromophenyl)-2,2':6',2''-terpyridine)](PF6)4*2KPF6

Conditions	Yield
In N,N-dimethyl-formamide suspn. Ru complex and ligand in DMF was refluxed for 15 min, react. mixt. was cooled, KPF6 was added; ppt. was filtered, soln. was evapd., dissolved in MeCN and treated with aq. KPF6, ppt. was filtered, dissolved in MeCN and chromd. on silica (MeCN-aq.KNO3 9:1), aq. KPF6 was added, ppt. was dissolved in MeCN and pptd. with water; elem. anal.;	30%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + [Ir(hydrido)2(acetone)2(triphenylphosphine)2](BF4) (82582-67-0, 72414-17-6) + chloroform (67-66-3) → [Ir2(hydrido)4(triphenylphosphine)4(1,4-bis(2,2':6',2''-terpyridine-4'-yl)benzene)](BF4)2*6CHCl3

Conditions	Yield
In chloroform (Ar); using Schlenk techniques; mixing of (IrH2(PPh3)2(acetone)2)(BF4) (1 equiv.) and 1,4-bis(2,2':6',2''-terpyridine-4'-yl)benzene (1 equiv.) in CHCl3 overnight; filtration, placing of filtrate in glass tubes and layering with hexane;sealing of tubes, standing at room temp. for 3 days; elem. anal.;	28%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + [Pt(C6F4CF3)2(S(C2H5)2)2] (198560-46-2) → [Pt(C6F4CF3)2C36H24N6] (217639-51-5)

Conditions	Yield
In not given (N2); elem. anal.;	28%

potassium hexafluorophosphate (17084-13-8) + 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + bis(μ-chloro)-bis[1,3-di(2-pyridyl)-4,6-dimethylbenzene-N,C(2'),N-iridium chloride] → [(1,3-dipyridyl-4,6-dimethylbenzene(1-))Ir(tpy-ph-tpy)Ir(1,3-dipyridyl-4,6-dimethylbenzene(1-))](PF6)4

Conditions	Yield
In water; ethylene glycol (under Ar); suspn. of Ir-complex and ligand in ethylene glycol refluxed for 45 min, cooled to room temp., H2O added, aq. soln. of KPF6 added; ppt. collected, washed with H2O, dissolved in MeCN, solvent removed, purified on silica gel chromy. with MeCN/H2O/KNO3 100/3/0.3-100/20/2;	26%

ammonium hexafluorophosphate + 1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + RuCl3(C5H2N(SO2CH3)(C5H4N)2) (146082-25-9) → [C5H4NC5H2(O2SCH3)NC5H4N]Ru[(C5H4NC5H2NC5H4N)2C6H4](2+)*2PF6(1-)=[(C15H10(O2SCH3)N3)Ru((C15H10N3)2C6H4)](PF6)2

Conditions

Yield

In methanol; water; ethylene glycol suspn. of the terpyridine and Ru-complex in 1,2-ethanediol refluxed (45min), red soln. allowed to cool, addn. H2O and excess NH4PF6/MeOH (pptn.); ppt. redissolved in min. amt. CH3CN, column chromy. (silica; CH3CN, satd. aq. KNO3, H2O (7:1:0.5 v/v)), main orange fraction collected, addn. H2O and excess NH4PF6/MeOH, partial evapn. (vac.), pptn., recrystn. (acetone/MeOH (1:1));

22%

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene (146406-75-9) + 1,4-butylenediphosphonic acid (4671-77-6) + hydrogen fluoride (7664-39-3) + copper(II) acetate monohydrate (6046-93-1) + molybdenum(VI) oxide → [Cu4(H2O)2(1,4-bis(2,2':6',2''-terpyridin-4'-yl)benzene)2(1,4-butylenediphosphonate)2(Mo4O21F)2]*4H2O + [Cu4(H2O)2(1,4-bis(2,2':6',2''-terpyridin-4'-yl)benzene)2(1,4-butylenediphosphonate)2(Mo4O21F)2]*6H2O

Conditions	Yield
In hydrogen fluoride aq. HF; High Pressure; mixt. Cu acetate, MoO3, benzene-bis(terpyridine), butylenediphosphonic acid, H2O, and HF (molar ratio=2.11:5.63:1.00:2.48:6010.8:248.43) heatedat 180°C for 2 d;	A 20% B n/a

Upstream product

• 623-27-8 terephthalaldehyde, 
• 6515-13-5 2-isopropenylpyridine 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 1122-62-9 2-acetylpyridine 
• 210306-18-6 3-[4-(3-oxo-3-pyridin-2-yl-propenyl)-phenyl]-1-pyridin-2-yl-propenone 

Downstream Products

• 238761-42-7 Fe⁽²⁺⁾*C₁₅N₃H₁₀C₆H₄C₁₅N₃H₁₀=FeC₁₅N₃H₁₀C₆H₄C₁₅N₃H₁₀⁽²⁺⁾ 
• 1009409-24-8 Ru⁽²⁺⁾*(C₁₅H₁₀N₃)2C₆H₄=Ru((C₁₅H₁₀N₃)2C₆H₄)⁽²⁺⁾ 

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Terpyridine derivatives as turn-on fluorescence chemosensors for the selective and sensitive detection of Zn2+ ions in solution and in live cells

A terpyridine based compound L1 was designed and synthesized as an off-on chemosensor for the detection of Zn2+. Chemosensor L1 showed excellent selectivity and sensitivity toward Zn2+ by exhibiting a large fluorescence enhancement (～51-fold) at 370 nm whereas other competitive metal ions did not show any noticeable change in the emission spectra of chemosensor L1. The chemosensor (L1) was shown to detect Zn2+ ions down to 9.76 μM at pH 7.4. However, chemosensor L1 binds Zn2+ in a 1:2 ratio (receptor:metal) with an association constant of 1.85 × 104 (R2 = 0.993) and this 1:2 stoichiometric fashion is established on the basis of a Job plot and mass spectroscopy. DFT/TD-DFT calculations were carried out to understand the binding nature, coordination features and electronic properties of L1 and the L1-2Zn2+ complex. In addition, this turn-on fluorescence probe was effectively used to image intracellular Zn2+ ions in cultured MDA-MB-468 cells.

Spectroscopic and antimicrobial activity of photoactivatable tricarbonyl Mn(I) terpyridine compounds

The photoinduced fac-[MnBr(CO)3(L–k2N1,N2)] (L = 4′-(2-pyridyl)-2,2′:6′,2′'-terpyridine (LPy) (1) and 4′-(4-phenyl morpholine)-2,2′:6′,2′'-terpyridine (Lmorph) (2)) and fac-[Mn2B

Terpyridine Zn(II) azide compounds: Spectroscopic and DFT calculations

Square-pyramidal Zn(II) azide complexes with the formula of [Znn(N3)2nL] (n = 1; L = 4′-(2-pyridyl)-2,2′:6′,2′'-terpyridine (LPy), 4′-(4-phenylmorpholine)-2,2′:6′,2′'-terpyridine (LMorph), and n = 2; L = 1,4-bis(2,2′:6′,2′'-terpyridin-4′-yl)benzene (LBPY)) were synthesized, and structurally characterized using different spectroscopic and analytical tools. Ground-state geometry optimization and harmonic vibrational analysis were carried out at two different levels of theory (B3LYP/LANL2DZ and CAM-B3LYP/def2-SVP) to gather insights into the local minimum structures. Natural bond orbital (NBO) analyses revealed that the electronic population of the 3d orbitals of Zn(II) ion is corresponding to the oxidation state of Zn(I), not Zn(II), in agreement with the ligand to metal charge transfer. Molecular electrostatic potential energy maps showed that the azido ligand may act as a nucleophile in the cycloaddition coupling with electron poor dipolar molecules. The electronic structure and transitions were investigated by executing time dependent density functional theory (TDDFT) calculations.

Binuclear metal iridium complex as well as preparation method and application thereof

The invention relates to the technical field of medicines, in particular to a binuclear metal iridium complex as well as a preparation method and application thereof. The binuclear cyclometallated iridium photosensitizer shown in the formula (I) is non-toxic to tumor cells under the dark condition, but has very strong growth inhibition ability to the tumor cells under the illumination condition, has important significance for researching high-efficiency and low-toxicity anti-tumor drugs, can be further used for preparing the anti-tumor drugs, and has a great application prospect.