146448-53-5

Basic information

• Product Name: 4-METHYL-N-(2-METHYL-BENZOYL)-BENZENESULFONAMIDE
• Synonyms: 4-METHYL-N-(2-METHYL-BENZOYL)-BENZENESULFONAMIDE
• CAS NO: 146448-53-5
• Molecular Formula: C₁₅H₁₅NO₃S
• Molecular Weight: 289.3495
• Mol File: 146448-53-5.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-METHYL-N-(2-METHYL-BENZOYL)-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-N-(2-METHYL-BENZOYL)-BENZENESULFONAMIDE(146448-53-5)
• EPA Substance Registry System: 4-METHYL-N-(2-METHYL-BENZOYL)-BENZENESULFONAMIDE(146448-53-5)

Safety Data

• Hazardous Substances Data: 146448-53-5(Hazardous Substances Data)

Usage

Uses

2-Methyl-N-[(4-methylphenyl)sulfonyl]benzamide is an intermediate in synthesizing 1,7-Dimethylfluorene (D465730), a product of the selenium dehydrogenation of gibberic acid. 1,7-Dimethylfluorene is also one of the many polyaromatic hydrocarbons (PAH) that are found within lake sediments, negatively impacting zoo plankton changes in the water, as well as the ecosystems that reside there.

Upstream product

• 95-49-8 2-methylchlorobenzene 
• 70-55-3 toluene-4-sulfonamide 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 529-20-4 2-methylphenyl aldehyde 
• 118-90-1 ortho-methylbenzoic acid 
• 933-88-0 ortho-toluoyl chloride 
• 4083-64-1 Tosyl isocyanate 
• 941-55-9 4-toluenesulfonyl azide 
• 10311-74-7 2,2'-dimethyl-stilbene 
• 70841-00-8 dibutyl di(p-methylphenyl)tin 
• 937-12-2 4-tolyltrimethylstannane 
• 68971-87-9 (2-tolyl)tributyltin 

Downstream Products

• 1369577-10-5 3-methyl-4'-nitro-N-(4-methylbenzenesulfonyl)biphenyl-2-carboxamide 
• 1369577-24-1 3-methyl-3'-nitro-N-(4-methylbenzenesulfonyl)biphenyl-2-carboxamide 
• 1369577-12-7 4'-chloro-3-methyl-N-(4-methylbenzenesulfonyl)biphenyl-2-carboxamide 
• 1369577-22-9 3'-methoxy-3-methyl-N-(4-methylbenzenesulfonyl)biphenyl-2-carboxamide 
• 1369577-28-5 2'-methoxy-3-methyl-N-(4-methylbenzenesulfonyl)biphenyl-2-carboxamide 
• 1369577-18-3 3,3'-dimethyl-N-(4-methylbenzenesulfonyl)biphenyl-2-carboxamide 
• 1369576-86-2 3,4'-dimethyl-N-(4-methylbenzenesulfonyl)biphenyl-2-carboxamide 
• 1369577-16-1 4'-bromo-3-methyl-N-(4-methylbenzenesulfonyl)biphenyl-2-carboxamide 
• 1369577-14-9 4'-methoxy-3-methyl-N-(4-methylbenzenesulfonyl)biphenyl-2-carboxamide 
• 1369577-30-9 2'-fluoro-3-methyl-N-(4-methylbenzenesulfonyl)biphenyl-2-carboxamide 
• 1369577-20-7 3-methyl-3'-(trifluoromethyl)-N-(4-methylbenzenesulfonyl)biphenyl-2-carboxamide 
• 1055309-74-4 (4R,5R)-2-(2-methylphenyl)-4,5-diphenyl-4,5-dihydrooxazole 

Relevant articles and documents

Ruthenium-Catalyzed Addition of Aromatic Amides to Internal Alkynes and Subsequent Intramolecular Cyclization for the Atom-Economical Synthesis of Isoindolinones

A selective and atom-economical synthesis of isoindolinones is described. This novel synthetic strategy involves two catalytic reactions: the ruthenium-catalyzed regioselective alkenylation of aromatic C-H bond of aromatic amides with internal alkynes, an

Ru(ii)-catalyzed allenylation and sequential annulation of: N -tosylbenzamides with propargyl alcohols

We hereby report Ru(ii)-catalyzed C(sp2)-H allenylation of N-tosylbenzamides to access multi-substituted allenylamides. Furthermore, the allenylamides were converted to the corresponding isoquinolone derivatives via base mediated annulation. The current protocol features low catalyst loading, mild reaction conditions, high functional group compatibility and desired scalability. The unique functionality of the afforded allenes allowed further transformations to expand the practicality of the protocol. This journal is

Controllable construction of isoquinolinedione and isocoumarin scaffolds: Via RhIII-catalyzed C-H annulation of N -tosylbenzamides with diazo compounds

A highly efficient protocol for the synthesis of isoquinolinediones by RhIII-catalyzed C-H activation/annulation/decarboxylation of N-tosylbenzamides with diazo compounds is reported. The switchable synthesis of isocoumarins was also achieved successfully via C-H activation/annulation with slight modification of the reaction conditions. Importantly, the synthetic utility of this new reaction was further demonstrated in an atom-economical and operationally convenient total synthesis of a TDP2 inhibitor derivative from commercially available starting materials.