146464-98-4Relevant academic research and scientific papers
Nucleophilic trifluoromethylation of conjugate acceptors via phenyl trifluoromethyl sulfone
Sakavuyi, Kaumba,Petersen, Kimberly S.
supporting information, p. 6129 - 6132 (2013/10/22)
A mild procedure for the conjugate addition of the trifluoromethyl anion to activated Michael acceptors such as arylidenemalononitriles (15 examples) and arylidene Meldrum's acids (9 examples) using phenyl trifluoromethyl sulfone through a reductive magnesium metal mediated procedure is described. The new methodology is used to prepare befloxatone, a reversible and selective monoamine oxidase A inhibitor.
Nucleophilic trifluoromethylation of arylidene Meldrum's acids
Zemtsov, Artem A.,Levin, Vitalij V.,Dilman, Alexander D.,Struchkova, Marina I.,Belyakov, Pavel A.,Tartakovsky, Vladimir A.
supporting information; experimental part, p. 2998 - 3000 (2009/09/28)
A method for the trifluoromethylation of arylidene Meldrum's acids using Me3SiCF3 followed by transformation of the initial products to CF3-substituted esters and alcohols is described. The sequence of reactions is perform
Synthesis and Properties of Optically Active α-Trifluoromethylbenzyl Derivatives as New Chiral Dopants for Ferroelectric Liquid Crystals
Aoki, Yoshio,Nohira, Hiroyuki
, p. 113 - 116 (2007/10/02)
Optically active α-trifluoromethylbenzyl derivatives as new chiral dopants for ferroelectric liquid crystals (FLCs) were synthesized utilizing optically active 4,4,4-trifluoro-3-(4-methoxyphenyl)butanoic acid prepared by optical resolution procedures.The
