15795-54-7Relevant articles and documents
Synthesis and crystal structure of 5-(4-methoxybenzylidene)-2,2-dimethyl-1, 3-dioxane-4,6-dione
Zeng, Wulan
, p. 864 - 866 (2013)
A new Meldrum's acid compound 5-(4-methoxybenzylidene)-2,2-dimethyl-1,3- dioxane-4,6-dione was prepared by 2,2-dimethyl-1,3-dioxane- 4,6-dione with 4-methoxybenzaldehyde in ethanol and its crystal structure was determined by X-ray crystallographic techniq
Synthesis, crystal structure and molecular modeling (AM1) of two 5-arylidene derivatives of Meldrum's acid
De Armas, Hector Novoa,Blaton, Norbert M.,Peeters, Oswald M.,De Ranter, Camiel J.,Suarez, Margarita,Ochoa, Estael,Verdecia, Yamila,Salfran, Esperanza
, p. 189 - 194 (2000)
The synthesis and structural characterization of two 5-Arylidene derivatives of Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione) are described: 5-(4-Nitrobenciliden)-2,2-dimethyl-1,3-dioxane-4,6-dione (3a), and 5-(4-Methoxybenciliden)-2,2-dimethyl-1,3-
Clean synthesis in water. Part 2: Uncatalysed condensation reaction of Meldrum's acid and aldehydes
Bigi, Franca,Carloni, Silvia,Ferrari, Leonetto,Maggi, Raimondo,Mazzacani, Alessandro,Sartori, Giovanni
, p. 5203 - 5205 (2001)
The environment-friendly condensation of Meldrum's acid and aromatic, heteroaromatic and hindered aliphatic aldehydes is performed carrying out the reaction in water at 75°C for 2 h, avoiding the addition of any catalyst.
Enantioselective Ammonium Ylide Mediated One-Pot Synthesis of Highly Substituted γ-Butyrolactones
Drennhaus, Till,?hler, Laura,Djalali, Saveh,H?fmann, Svenja,Müller, Clemens,Pietruszka, J?rg,Worgull, Dennis
supporting information, p. 2385 - 2396 (2020/04/30)
An ammonium ylide mediated access towards trans-β,γ-disubstituted, all-trans-α,β,γ-trisubstituted, and α,α,β,γ-tetrasubstituted γ-butyrolactones bearing a broad variety of functionalities was developed. Starting from widely accessible benzylidene Meldrum's acid derivatives and α-bromo carbonyl compounds, γ-butyrolactones were obtained in yields between 32–99% with up to excellent diastereoselectivities (>95:5) via a DABCO-mediated [2+1] annulation. Utilization of enantiomerically pure cinchona alkaloid derivatives enables the first asymmetric ammonium ylide mediated method to provide (3R,?4R)-β,γ-disubstituted and (2R,?3R,?4R)-α,β,γ-trisubstituted γ-butyrolactones in moderate to good yields with up to very good enantiomeric ratios (97:3). The scalability of the transformation was proven while determining the absolute configuration. (Figure presented.).
An alternative, practical, and ecological protocol for synthesis of arylidene analogues of Meldrum’s acid as useful intermediates
Khaligh, Nader Ghaffari,Mihankhah, Taraneh,Johan, Mohd Rafie
, (2019/03/17)
This paper presents an ecological protocol for Knoevenagel condensation using a catalytic amount of 4,4′-trimethylenedipiperidine as a versatile, efficient, safe, commercially available, inexpensive, and recyclable organocatalyst by a ball-milling process