15795-54-7

Usage

Uses

Used in Pharmaceutical Industry:
5-[(4-Methoxyphenyl)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione is used as a building block for the synthesis of pharmaceuticals. Its unique structure allows for the creation of new molecules with potential therapeutic applications.
Used in Agrochemical Industry:
5-[(4-Methoxyphenyl)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione is used as a building block for the synthesis of agrochemicals. Its properties can be utilized to develop new compounds with agricultural applications, such as pesticides or herbicides.
Used in Organic Chemistry Research:
5-[(4-Methoxyphenyl)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione is used as a research compound in the field of organic chemistry. Its structure and properties can be studied to understand its reactivity and potential use in the synthesis of other complex molecules. Further research and testing may reveal the full potential of 5-[(4-METHOXYPHENYL)METHYLENE]-2,2-DIMETHYL-1,3-DIOXANE-4,6-DIONE in various applications.

Upstream product

• 3229-70-7 phenolate 
• 123-11-5 4-methoxy-benzaldehyde 
• 121072-18-2 triphenylbismuthonio-4,4-dimethyl-2,6-dioxo-3,5-dioxane-1-ide 
• 2033-24-1 cycl-isopropylidene malonate 
• 631-61-8 ammonium acetate 
• 126-81-8 dimedone 
• 670-54-2 ethenetetracarbonitrile 
• 3585-93-1 N-(4-methoxybenzylidene)aniline oxide 
• 1995-50-2 (4-dimethylaminophenyl)diphenylmethylium tetrafluoroborate 
• 437-30-9 4,4',4-trimethoxytrityl tetrafluoroborate 
• 1650-48-2 tris(4-methylphenyl)methylium tetrafluoroborate 
• 67-64-1 acetone 
• 1214-54-6 5-benzylidene Meldrum's acid 
• 622-72-0 N-(4-methoxylbenzylidene)benzylamine 

Downstream Products

• 53942-72-6 2,4-Bis(4'-methoxybenzyliden)cyclobutan-1,3-dion 
• 6258-50-0 1-(4-Methoxy-benzyl)-6,6-dimethyl-5,7-dioxa-spiro[2.5]octane-4,8-dione 
• 131447-65-9 4-(4-Methoxy-phenyl)-1,7,7-trimethyl-4,6,7,8-tetrahydro-1H,3H-quinoline-2,5-dione 
• 132600-25-0 4-(4-Methoxy-phenyl)-1-phenyl-4,6,7,8-tetrahydro-1H,3H-quinoline-2,5-dione 
• 132600-26-1 4-[4-(4-Methoxy-phenyl)-2,5-dioxo-3,4,5,6,7,8-hexahydro-2H-quinolin-1-yl]-benzoic acid 
• 132600-27-2 2-[4-(4-Methoxy-phenyl)-2,5-dioxo-3,4,5,6,7,8-hexahydro-2H-quinolin-1-yl]-benzoic acid 
• 103248-27-7 2,2-dimethyl-5-(p-methoxyphenyl)-4,4a,5,6-tetrahydro-m-dioxeno<4,5-c>pyrazol-2(H)-one 
• 97381-40-3 1-(4-Methoxy-phenyl)-6,6-dimethyl-5,7-dioxa-spiro[2.5]octane-4,8-dione 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-09-4 4-methoxybenzoic acid 
• 75307-59-4 5-Hydroxy-Meldrums Saeure 
• 88220-96-6 (4S,5S)-4-Acetyl-5-(4-methoxy-phenyl)-dihydro-furan-2-one 

Relevant academic research and scientific papers

Synthesis and crystal structure of 5-(4-methoxybenzylidene)-2,2-dimethyl-1, 3-dioxane-4,6-dione

A new Meldrum's acid compound 5-(4-methoxybenzylidene)-2,2-dimethyl-1,3- dioxane-4,6-dione was prepared by 2,2-dimethyl-1,3-dioxane- 4,6-dione with 4-methoxybenzaldehyde in ethanol and its crystal structure was determined by X-ray crystallographic techniq

Meldrum's acid catalyzed reaction of tetracyanoethylene and aldehydes in water: A novel approach to arylidenemalononitrile

Meldrum's acid catalyzed the reaction of tetracyanoethylene with aromatic, heteroaromatic, and conjugated aldehydes led to arylidenemalononitrile in water in good yields at 80° C. The work-up of reactions is very simple and the crude products are sufficiently pure to be used without further purification. The procedure provides an alternative method for the synthesis of arylidenemalononitrile.

Synthesis, crystal structure and molecular modeling (AM1) of two 5-arylidene derivatives of Meldrum's acid

The synthesis and structural characterization of two 5-Arylidene derivatives of Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione) are described: 5-(4-Nitrobenciliden)-2,2-dimethyl-1,3-dioxane-4,6-dione (3a), and 5-(4-Methoxybenciliden)-2,2-dimethyl-1,3-

A novel light induced Knoevenagel condensation of Meldrum's acid with aromatic aldehydes in aqueous ethanol

A highly efficient environment-friendly photochemical methodology has been developed for the condensation of Meldrum's acid with aromatic aldehydes in water-ethanol solution sans any catalyst, support or promoter.

Clean synthesis in water. Part 2: Uncatalysed condensation reaction of Meldrum's acid and aldehydes

The environment-friendly condensation of Meldrum's acid and aromatic, heteroaromatic and hindered aliphatic aldehydes is performed carrying out the reaction in water at 75°C for 2 h, avoiding the addition of any catalyst.

Bentonite catalyzed an efficient and green synthesis of arylidene meldrum's acid derivatives in aqueous media

In the present paper, a simple, highly efficient, and environmentally friendly protocol was proposed for the Knoevenagel condensation reaction of aromatic aldehydes using Meldrum’s acid (2,2-dimethyl-4,6-dioxo-1,3-dioxane) with bentonite as an available n

Enantioselective Ammonium Ylide Mediated One-Pot Synthesis of Highly Substituted γ-Butyrolactones

An ammonium ylide mediated access towards trans-β,γ-disubstituted, all-trans-α,β,γ-trisubstituted, and α,α,β,γ-tetrasubstituted γ-butyrolactones bearing a broad variety of functionalities was developed. Starting from widely accessible benzylidene Meldrum's acid derivatives and α-bromo carbonyl compounds, γ-butyrolactones were obtained in yields between 32–99% with up to excellent diastereoselectivities (>95:5) via a DABCO-mediated [2+1] annulation. Utilization of enantiomerically pure cinchona alkaloid derivatives enables the first asymmetric ammonium ylide mediated method to provide (3R,?4R)-β,γ-disubstituted and (2R,?3R,?4R)-α,β,γ-trisubstituted γ-butyrolactones in moderate to good yields with up to very good enantiomeric ratios (97:3). The scalability of the transformation was proven while determining the absolute configuration. (Figure presented.).

Boron/zinc exchange for the conjugate arylation of unsaturated Meldrum's acid derivatives

An approach for the conjugate arylation reaction of unsaturated Meldrum's acid derivatives is reported. The reaction takes place through a Boron-Zinc exchange reaction between arylboronic acids and diethylzinc and the subsequent transfer of thus generated reactive aryl groups to the β-position of the double bond of the Meldrum's derivatives. The compounds obtained are valuable synthetic intermediates and can give rise to bioactive molecules such as β,β-disubstituted carboxylic acids and amides.

An alternative, practical, and ecological protocol for synthesis of arylidene analogues of Meldrum’s acid as useful intermediates

This paper presents an ecological protocol for Knoevenagel condensation using a catalytic amount of 4,4′-trimethylenedipiperidine as a versatile, efficient, safe, commercially available, inexpensive, and recyclable organocatalyst by a ball-milling process

Microwave-associate synthesis of Co3O4 nanoparticles as an effcient nanocatalyst for the synthesis of arylidene barbituric and Meldrum's acid derivatives in green media

In this study, Co3O4 nanocatalysts were constructed in environmentally appropriate conditions using controlled, effective, and facile microwave method. The final nanostructures were characterized by SEM, XRD, and TEM analyses. The products had a small size distribution, homogeneous morphology, and crystallographic structures associated with the formation of Co3O4 nanostructures. Moreover, EDS mapping analysis confirmed the existence of Co and O elements in the final structure, and the magnetic properties of the samples were investigated by VSM. The application of this nanostructure in a catalytic process was further examined, and the results suggested that it could be used as a novel candidate for the synthesis of arylidene barbituric and Meldrum,s acid through Knoevenagel condensation of aldehydes by barbituric and Meldrum,s acid in aqueous media. The high yield of these nanocatalysts would be justified by the nature of the nanostructure as well as the experimental procedure developed in this study, which affected the physicochemical features of the products.