14663-46-8

Usage

Uses

Used in Pharmaceutical Industry:
3-AMINO-4(3H)-QUINAZOLINONE 97 is used as a compound in the study of anticonvulsant activity and neurotoxicity for the development of new medications. Its application is based on the compound's potential to exhibit anticonvulsant properties, which could be beneficial in the treatment of seizure disorders and epilepsy.
Additionally, the compound may also be used in the study of neurotoxicity, which is essential for understanding the safety and side effects of potential new drugs. This information can help researchers develop safer and more effective medications for neurological conditions.

Synthesis Reference(s)

The Journal of Organic Chemistry, 13, p. 903, 1948 DOI: 10.1021/jo01164a021

InChI:InChI=1/C8H7N3O/c9-11-5-10-7-4-2-1-3-6(7)8(11)12/h1-5H,9H2

Upstream product

• 16347-60-7 3-phenyl-4(3H)-quinazolinone 
• 491-36-1 4-Hydroxyquinazoline 
• 64-18-6 formic acid 
• 1904-58-1 anthranilic acid hydrazide 
• 104907-89-3 5-(4-Oxo-4H-quinazolin-3-yl)-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 95-92-1 oxalic acid diethyl ester 
• 553-90-2 Dimethyl oxalate 
• 31499-90-8 2,1-benzisoxazol-3(1H)-one 
• 104907-77-9 N-(1-phenyl-4-carboethoxypyrazol-5-yl)-2-nitrobenzamide 
• 118-48-9 isatoic anhydride 
• 28144-70-9 anthranilic acid amide 
• 68-12-2 N,N-dimethyl-formamide 
• 610-14-0 2-nitrobenzyl chloride 
• 104907-79-1 5-(2-Amino-benzoylamino)-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester 

Downstream Products

• 16347-87-8 3-(acetylamino)-4(3H)-quinazolinone 
• 14663-55-9 3-benzoylamino-3H-quinazolin-4-one 
• 14663-50-4 diacetylamino-3 (3H) quinazolinone-4 
• 951781-23-0 N-[4-chloro-2-(1-{4⁽³⁾-oxo-quinazolin-3-yl}imino)ethylphenyl]-trifluoromethanesulfonamide 
• 66645-62-3 1-(4-oxoquinazolin-3(4H)-yl)-3-phenylthiourea 
• 1412906-48-9 C₂₇H₂₁N₄O₆P 
• 1412906-46-7 C₂₇H₂₁ClN₃O₄P 
• 1412906-45-6 C₂₇H₂₂N₃O₆P 
• 158655-80-2 1-(p-Bromophenyl)-3-(3,4-dihydro-4-oxo-3-quinazolinyl)-2-thiourea 
• 959756-96-8 3-(o-aminobenzoylhydrazinocarbonyl)-N-(4-oxo-3,4-dihydroquinazolin-3-yl)propanamide 

Relevant academic research and scientific papers

Reactions of ethyl oxamate and dialkyl oxalates with anthranilic acid derivatives

Ethyl oxamate reacted with anthranilic acid derivatives at the amide or the ester group leading to the formation of respective esters or amides. A simple method was developed for preparation of alkyl 3-amino-4-oxo-3,4- dihydroquinazoline-2-carboxylates. Nauka/Interperiodica 2007.

Imidazolium chloride as an additive for synthesis of 4(3H)-quinazolinones using anthranilamides and DMF derivatives

Imidazolium chloride as an environmentally benign additive efficiently facilitates construction of 4(3H)-quinazolinones using anthranilamides and DMF derivatives. A series of 4(3H)-quinazolinones were prepared in moderate to excellent yields without conventional oxidants, metal catalysts and corrosive acids or other additives.

Polycyclic N-heterocyclic compounds. Part 601): Reactions of 3-(2-cyanophenyl)quinazolin-4(3H)-ones with primary amines

The reaction of 3-(2-cyanophenyl)quinazolin-4(3H)-one with various primary alkylamines gave 3-alkylquinazolin-4(3H)-ones via an addition of the nucleophile, ring opening, and ring closure (ANRORC) mechanism. This type of reaction required hydroxy group fu

Synthesis of N-(4-oxo-3,4-dihydroquinazolin-3-yl)succinimide and N-(4-oxoquinazolin-3-yl)succinamic acid derivatives based thereon

The reaction of anthranilic acid hydrazide with diethyl oxalate under microwave irradiation was accompanied by decarboxylation with formation of 3-amino-3,4-dihydroquinazolin-4-one, and acylation of the latter with succinic anhydride gave N-(4-oxo-3,4-dihydroquinazolin-3-yl)siccinimide which was converted into various N-(4-oxo-3,4-dihydroquinazolin-3-yl)succinamic acid derivatives. Nauka/Interperiodica 2007.

N-PHENYL-1,1,1-TRIFLUOROMETHANESULFONAMIDE HYDRAZONE DERIVATIVE COMPOUNDS AND THEIR USAGE IN CONTROLLING PARASITES

Novel N-phenyl-1,1,1-trifluoromethanesulfonamide compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo and ex vivo.

Synthesis of new 3,4-di-and 1,2,3,4-tetrahydroquinazolin-4-one derivatives and X-ray diffraction study of crystal solvates of 3-methylsulfonylamino-2-(2- methylsulfonylaminophenyl)-1,2,3,4-tetrahydroquinazolin-4-one

The reactions of hydrazide, mesyl hydrazide, succinyl hydrazide, and maleyl hydrazide of anthranilic acid with carbonyl compounds were studied, and new di-and tetrahydroquinazolin-4-one derivatives were prepared. The structure of one reaction product, viz., 3-methylsulfonylamino-2-(2- methylsulfonylaminophenyl)-1,2,3,4-tetrahydroquinazolin-4-one, was established by X-ray diffraction study of two crystal solvates of this compound. The characteristic features of the crystal packings of these solvates are discussed. Springer Science+Business Media, Inc. 2006.

1-aryl-3-(3,4-dihydro-4-oxo-3-quinazolinyl)urea fungicidal agents

1-Aryl-3-(3,4-dihydro-4-oxo-3-quinazolinyl)-urea compounds which are effective for the control of prevention of phytopathogenic fungi are described. A method for the fungicidal use of said compounds, fungicidal compositions containing said compounds and m

1-aryl-3-(3.4-dihydro-4-oxo-3-quinazolinyl)urea fungicidal agents

1-Aryl-3-(3,4-dihydro-4-oxo-3-quinazolinyl)urea compounds which are effective for the control or prevention of phytopathogenic fungi are described. A method for the fungicidal use of said compounds and fungicidal compositions containing said compounds is

Reaction of 2-Aminobenzoylhydrazines with Carboxylic Acids: Formation of Quinazolin-4(3H)-one, 1,3,4-Oxadiazole and 1,3,4-Benzotriazepin-5-one Derivatives

Reactions of 2-aminobenzoylhydrazines with aliphatic acids give 1-(2'-acylaminobenzoyl)-2-acylhydrazines (4) which are cyclised to 3-amino-2-alkylquinazolin-4(3H)-ones (6).Aromatic acids react with 2-aminobenzoylhydrazines to give a mixture of 1-(2'-amino