226410-00-0

Basic information

• Product Name: Methyl 3-chloro-1H-pyrrole-2-carboxylate
• Synonyms: Methyl 3-chloro-1H-pyrrole-2-carboxylate;Methyl 3-chloro-1H-pyrrol...;Methyl 3-Chloropyrrole-2-carboxylate
• CAS NO: 226410-00-0
• Molecular Formula: C₆H₆ClNO₂
• Molecular Weight: 159.57034
• Mol File: 226410-00-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 270.6±20.0 °C(Predicted)
• Appearance: /
• Density: 1.356±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.58±0.50(Predicted)
• CAS DataBase Reference: Methyl 3-chloro-1H-pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-chloro-1H-pyrrole-2-carboxylate(226410-00-0)
• EPA Substance Registry System: Methyl 3-chloro-1H-pyrrole-2-carboxylate(226410-00-0)

Safety Data

• Hazardous Substances Data: 226410-00-0(Hazardous Substances Data)

Usage

General Description

Methyl 3-chloro-1H-pyrrole-2-carboxylate is a chemical compound with the molecular formula C7H6ClNO2. It is a pyrrole derivative with a methyl ester group and a chlorine atom attached to the pyrrole ring. Methyl 3-chloro-1H-pyrrole-2-carboxylate is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is known for its reactivity in various chemical reactions, making it a valuable building block in organic synthesis. Methyl 3-chloro-1H-pyrrole-2-carboxylate is also used in research and development in the field of medicinal chemistry. It is important to handle this compound with caution, as it may pose health and environmental risks if not properly managed.

Upstream product

• 872-32-2 2-methyl-1H-pyrroline 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 226409-94-5 4,4-dichloro-5-(trichloromethyl)-3,4-dihydro-2H-pyrrole 
• 226409-98-9 3-chloro-2-(trimethoxymethyl)pyrrole 

Downstream Products

• 1466565-96-7 3-chloro-N-phenyl-1H-pyrrole-2-carboxamide 
• 1403941-86-5 1-amino-3-chloro-N-phenyl-1H-pyrrole-2-carboxamide 
• 1466565-97-8 tert-butyl (S)-(1-((3-chloro-2-(phenylcarbamoyl)-1H-pyrrole-1-yl)amino)-1-oxopropane-2-yl)carbamate 
• 1466565-98-9 C₁₉H₂₁ClN₄O₃ 
• 1466565-99-0 C₁₄H₁₃ClN₄O 
• 1548332-55-3 (S)-2-(1-(9H-purin-6-yl)pyrrolidin-2-yl)-5-chloro-3-phenylpyrrolo[2,1-f][1, 2,4]triazin-4(3H)-one 

Relevant articles and documents

Synthesis of 2-acyl-3-chloropyrroles: Application to the synthesis of the trail pheromone of the ant Atta texana

Alkyl 3-chloropyrrole-2-carboxylates and 2-alkanoyl-3-chloropyrroles are conveniently prepared from 2-alkyl-1-pyrrolines by tetra- and pentahalogenation with N-chlorosuccinimide, subsequent base-induced aromatisation with sodium alkoxides in the corresponding alcohol and final acid hydrolysis of the resulting orthoester or acetal functions into the 3- chloropyrrole. The developed strategy is applied to the synthesis of the trail pheromone of the ant Atta texana.

INHIBITORS OF METALLO-BETA-LACTAMASES

The present invention relates to compounds of Formula (I) that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of a bacterial infection. (Formula (I))

Pyrimido oxazine derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for use in preventing or treating PI3 kinase related diseases

The present invention relates to pyrimido oxazine derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an effective component for preventing or treating PI3 kinase-related diseases. The pyrimido oxazine derivatives according to the present invention have excellent selective inhibitory effects on PI3 kinase, and thus may be beneficially used in preventing or treating PI3 kinase-related diseases such as the following: cancers including blood cancer, ovarian cancer, cervical cancer, breast cancer, large intestine cancer, liver cancer, stomach cancer, pancreatic cancer, colon cancer, periotoneal cancer, skin cancer, bladder cancer, prostate cancer, lung cancer, osteosarcoma, fibrous tumor, and brain tumor; autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, hyperthyroidism, myasthenia gravis, Crohnandprime;s disease, ankylosing spondylitis, psoriasis, pernicious anemia, and Sjogrenandprime;s syndrome; and respiratory diseases including chronic obstructive pulmonary disease (COPD), rhinitis, asthma, chronic bronchitis, chronic pulmonary inflammatory diseases, silicosis, pulmonary sarcoidosis, pleuritis, alveolitis, vasculitis, emphysema, pneumonia, and bronchiectasis.COPYRIGHT KIPO 2017