146741-06-2

Basic information

• Product Name: 2(1H)-Quinoxalinone,6-fluoro-3,4-dihydro-3-methyl-(9CI)
• Synonyms: 2(1H)-Quinoxalinone,6-fluoro-3,4-dihydro-3-methyl-(9CI);6-FLUORO-3-METHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE
• CAS NO: 146741-06-2
• Molecular Formula: C₉H₉FN₂O
• Molecular Weight: 180.18
• Product Categories: PIPERIDINE
• Mol File: 146741-06-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 341.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.209±0.06 g/cm3(Predicted)
• PKA: 12.73±0.40(Predicted)
• CAS DataBase Reference: 2(1H)-Quinoxalinone,6-fluoro-3,4-dihydro-3-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone,6-fluoro-3,4-dihydro-3-methyl-(9CI)(146741-06-2)
• EPA Substance Registry System: 2(1H)-Quinoxalinone,6-fluoro-3,4-dihydro-3-methyl-(9CI)(146741-06-2)

Safety Data

• Hazardous Substances Data: 146741-06-2(Hazardous Substances Data)

Usage

Structure

Synthetic derivative of quinoxalinone with a quinazoline core

Pharmacological properties

Potential anticonvulsant, anxiolytic, and anti-inflammatory effects
Enhanced pharmacokinetic and metabolic properties due to the presence of a fluorine atom

Use in pharmaceutical research and drug development

Attracts potential drug development.

Upstream product

• 868771-38-4 N-(2-amino-4-fluoro-phenyl)-2-chloro-propionamide 
• 868771-27-1 2-chloro-N-(4-fluoro-2-nitro-phenyl)-propionamide 
• 21262-04-4 2-chloro-N-(4-fluorophenyl)propanamide 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 98416-68-3 6-fluoro-3-methyl-1H-quinoxalin-2-one 

Relevant articles and documents

Synthesis and biological evaluation of N4-(hetero)arylsulfonylquinoxalinones as HIV-1 reverse transcriptase inhibitors

A series of novel N4-(hetero)arylsulfonylquinoxalinone derivatives were prepared in a straight and efficient way. Of all the synthesized compounds, five compounds exhibited potent anti-HIV-1 replication activities with IC50 value at

Novel approach to 3-methyl-1H-quinoxalin-2-ones

A novel approach to the synthesis of 3-methyl-1H-quinoxalin-2-ones has been described. These compounds were regioselectively prepared by starting from substituted phenylamines and α-chloropropionyl chloride through the efficient procedures of acylation, nitration, reduction, intramolecular alkylation, and oxidation. Copyright Taylor & Francis, Inc.