146741-06-2

Usage

Structure

Synthetic derivative of quinoxalinone with a quinazoline core

Pharmacological properties

Potential anticonvulsant, anxiolytic, and anti-inflammatory effects
Enhanced pharmacokinetic and metabolic properties due to the presence of a fluorine atom

Use in pharmaceutical research and drug development

Attracts potential drug development.

Upstream product

• 371-40-4 4-fluoroaniline 
• 21262-04-4 2-chloro-N-(4-fluorophenyl)propanamide 
• 868771-27-1 2-chloro-N-(4-fluoro-2-nitro-phenyl)-propionamide 
• 868771-38-4 N-(2-amino-4-fluoro-phenyl)-2-chloro-propionamide 

Downstream Products

• 98416-68-3 6-fluoro-3-methyl-1H-quinoxalin-2-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of N4-(hetero)arylsulfonylquinoxalinones as HIV-1 reverse transcriptase inhibitors

A series of novel N4-(hetero)arylsulfonylquinoxalinone derivatives were prepared in a straight and efficient way. Of all the synthesized compounds, five compounds exhibited potent anti-HIV-1 replication activities with IC50 value at

Synthesis of substituted 1,3-dimethyl-1H-quinoxalin-2-ones from aniline derivatives

Substituted 1,3-dimethyl-1H-quinoxalin-2-ones (7) have been synthesized through the procedures of acylation, nitration, reduction, intramolecular alkylation, oxidation, and N-methylation starting from 3,4-disubstituted aniline.

Novel approach to 3-methyl-1H-quinoxalin-2-ones

A novel approach to the synthesis of 3-methyl-1H-quinoxalin-2-ones has been described. These compounds were regioselectively prepared by starting from substituted phenylamines and α-chloropropionyl chloride through the efficient procedures of acylation, nitration, reduction, intramolecular alkylation, and oxidation. Copyright Taylor & Francis, Inc.