98416-68-3

Upstream product

• 141-97-9 ethyl acetoacetate 
• 98416-74-1 6-Fluoro-4-oxy-1H-quinoxalin-2-one 
• 21262-04-4 2-chloro-N-(4-fluorophenyl)propanamide 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 367-31-7 4-fluoro-1,2-phenylenediamine 
• 96089-45-1 N-(4-Fluoro-2-nitro-phenyl)-3-oxo-butyramide 
• 371-40-4 4-fluoroaniline 
• 868771-27-1 2-chloro-N-(4-fluoro-2-nitro-phenyl)-propionamide 
• 868771-38-4 N-(2-amino-4-fluoro-phenyl)-2-chloro-propionamide 
• 146741-06-2 6-fluoro-3-methyl-3,4-dihydroquinoxalin-2(1H)-one 

Relevant academic research and scientific papers

TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS

The present invention is directed to triazolopyrazine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psychiatric disorders.

Synthesis of substituted 1,3-dimethyl-1H-quinoxalin-2-ones from aniline derivatives

Substituted 1,3-dimethyl-1H-quinoxalin-2-ones (7) have been synthesized through the procedures of acylation, nitration, reduction, intramolecular alkylation, oxidation, and N-methylation starting from 3,4-disubstituted aniline.

Novel approach to 3-methyl-1H-quinoxalin-2-ones

A novel approach to the synthesis of 3-methyl-1H-quinoxalin-2-ones has been described. These compounds were regioselectively prepared by starting from substituted phenylamines and α-chloropropionyl chloride through the efficient procedures of acylation, nitration, reduction, intramolecular alkylation, and oxidation. Copyright Taylor & Francis, Inc.

SYNTHESIS OF NOVEL 6-SUBSTITUTED 2-CHLORO-3-METHYLQUINOXALINES

Facile synthesis of novel 6-substituted 2-chloro-3-methylquinoxalines (4a-d) is described.Intramolecular cyclization reaction of 4-substituted 2-nitroacetoacetanilides (1a-d) in basic conditions afforded 6-substituted 2(1H)-quinoxalinone-4-oxides (2a-d) and in situ, which could be converted into novel 6-substituted 3-methyl-2(1H)-quinoxalinones (3a-d) using ethyl acetoacetate. 3a-d were chlorinated with phosphoryl chloride to afford 4a-d.