146943-41-1

Basic information

• Product Name: 4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-4,4-dimethoxy-butyl]-benzoic acid tert-butyl ester
• Synonyms: 4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-4,4-dimethoxy-butyl]-benzoic acid tert-butyl ester
• CAS NO: 146943-41-1
• Molecular Weight: 418.493
• Mol File: 146943-41-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-4,4-dimethoxy-butyl]-benzoic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-4,4-dimethoxy-butyl]-benzoic acid tert-butyl ester(146943-41-1)
• EPA Substance Registry System: 4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-4,4-dimethoxy-butyl]-benzoic acid tert-butyl ester(146943-41-1)

Safety Data

• Hazardous Substances Data: 146943-41-1(Hazardous Substances Data)

Upstream product

• 126931-31-5 methyl 3-<4-(tert-butoxycarbonyl)phenyl>propanoate 
• 146943-27-3 methyl 3-<4-(tert-butoxycarbonyl)phenyl>propenoate 
• 134373-00-5 tert-butyl 4-(4-methoxy-3-butenyl)benzoate 
• 134372-99-9 3-(4-<2,2-dimethylethyl>carboxyphenyl)-1-propanal 
• 126931-32-6 tert-Butyl 4-(3-hydroxy-1-propyl)benzoate 
• 65874-27-3 4-(tert-butoxycarbonyl)benzaldehyde 
• 50-01-1 guanidine hydrochloride 

Downstream Products

• 146943-43-3 N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester 
• 137281-39-1 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid 

Relevant articles and documents

A Novel Synthetic Approach to Pyrrolopyrimidine Antifolates

A novel and efficient synthetic method for the synthesis of pyrrolopyrimidine antifolates is described.The key reaction of this method is the photo-initiated free radical addition of bromomalononitrile or ethyl bromocyanoacetate to an enol ether to afford the backbone skeleton of the targeted antifolate molecule.The key intermediates 3 or 4 are smoothly converted to the pyrrolopyrimidine antifolates 1 or 2 in three steps and in high overall yield.