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14702-42-2

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14702-42-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 14702-42-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,7,0 and 2 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 14702-42:
(7*1)+(6*4)+(5*7)+(4*0)+(3*2)+(2*4)+(1*2)=82
82 % 10 = 2
So 14702-42-2 is a valid CAS Registry Number.

14702-42-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name methoxycarbonylhydrazone of cyclohexanone

1.2 Other means of identification

Product number -
Other names carbomethoxyhydrazone of cyclohexanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14702-42-2 SDS

14702-42-2Relevant articles and documents

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors

Patel, Jayendra Z.,Parkkari, Teija,Laitinen, Tuomo,Kaczor, Agnieszka A.,Saario, Susanna M.,Savinainen, Juha R.,Navia-Paldanius, Dina,Cipriano, Mariateresa,Lepp?nen, Jukka,Koshevoy, Igor O.,Poso, Antti,Fowler, Christopher J.,Laitinen, Jarmo T.,Nevalainen, Tapio

supporting information, p. 8484 - 8496 (2013/12/04)

In the present study, identification of chiral 1,3,4-oxadiazol-2-ones as potent and selective FAAH inhibitors has been described. The separated enantiomers showed clear differences in the potency and selectivity toward both FAAH and MAGL. Additionally, the importance of the chirality on the inhibitory activity and selectivity was proven by the simplification approach by removing a methyl group at the 3-position of the 1,3,4-oxadiazol-2-one ring. The most potent compound of the series, the S-enantiomer of 3-(1-(4-isobutylphenyl)ethyl) -5-methoxy-1,3,4-oxadiazol-2(3H)-one (JZP-327A, 51), inhibited human recombinant FAAH (hrFAAH) in the low nanomolar range (IC50 = 11 nM), whereas its corresponding R-enantiomer 52 showed only moderate inhibition toward hrFAAH (IC50 = 0.24 μM). In contrast to hrFAAH, R-enantiomer 52 was more potent in inhibiting the activity of hrMAGL compared to S-enantiomer 51 (IC 50 = 4.0 μM and 16% inhibition at 10 μM, respectively). The FAAH selectivity of the compound 51 over the supposed main off-targets, MAGL and COX, was found to be >900-fold. In addition, activity-based protein profiling (ABPP) indicated high selectivity over other serine hydrolases. Finally, the selected S-enantiomers 51, 53, and 55 were shown to be tight binding, slowly reversible inhibitors of the hrFAAH.

Electrochemical oxidation of ketone acylhydrazones and their HCN adducts in NaCN-MeOH. Tranformation of ketones to nitriles

Okimoto,Chiba

, p. 1070 - 1076 (2007/10/02)

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