147149-85-7

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-6-BROMO-5-METHYLBENZOIC ACID serves as a crucial building block in the synthesis of a variety of drugs and pharmaceutical products. Its unique structure allows for the development of new therapeutic agents with specific biological activities.
Used in Anti-Inflammatory Applications:
2-AMINO-6-BROMO-5-METHYLBENZOIC ACID is utilized for its anti-inflammatory properties, making it a valuable component in the formulation of medications aimed at reducing inflammation and associated symptoms.
Used in Antimicrobial Applications:
2-AMINO-6-BROMO-5-METHYLBENZOIC ACID also exhibits antimicrobial properties, which can be harnessed in the development of new antibiotics or disinfectants to combat microbial infections.
Used in Agricultural Industry:
2-AMINO-6-BROMO-5-METHYLBENZOIC ACID is employed as an intermediate in the production of insecticides and herbicides, contributing to the development of more effective and targeted pest control solutions in agriculture.
Used in Chemical Industry:
Beyond its direct applications, 2-AMINO-6-BROMO-5-METHYLBENZOIC ACID also plays a role in the synthesis of various chemical intermediates, expanding its utility across different sectors within the chemical industry.

InChI:InChI=1/C8H8BrNO2/c1-4-2-3-5(10)6(7(4)9)8(11)12/h2-3H,10H2,1H3,(H,11,12)

Upstream product

• 147149-84-6 4-bromo-5-methyl-1H-indole-2,3-dione 
• 7745-91-7 3-bromo-4-methylaniline 

Downstream Products

• 1092448-25-3 C₂₀H₂₁BrN₂O₃ 
• 147149-89-1 2-amino-5-bromo-6-methyl-3-H-quinazolin-4-one 
• 147150-03-6 Diethyl N-<4-<(2-amino-6-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl>benzoyl>-L-glutamate 
• 147150-02-5 Diethyl-N-<4-<(2,6-dimethyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl>benzoyl>-L-glutamate 
• 147150-00-3 4-((2-amino-6-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl)benzoic acid methyl ester 
• 152946-39-9 4-((2,6-dimethyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl)benzoic acid methyl ester 
• 147150-01-4 4-(2-Amino-6-methyl-4-oxo-3,4-dihydro-quinazolin-5-ylsulfanyl)-benzoic acid 
• 147149-69-7 4-[(3,4-Dihydro-2,6-dimethyl-4-oxo-5-quinazolinyl)thio]-benzoic acid 
• 147149-88-0 methyl 2-amino-6-bromo-5-methylbenzoate 
• 502607-48-9 2-guanidino-5-bromo-3,4-dihydro-6-methylquinazolin-4-one 

Relevant academic research and scientific papers

TETRACYCLIC HETEROARYL COMPOUNDS

The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

CHEMICAL COMPOUNDS

The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

New straightforward synthesis of 2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)- 3H-quinazolin-4-one

The synthesis of 2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quinazolin-4- one (1) was studied via three different synthetic routes starting from 4-bromo-5-methylisatin. The best route was established, which is a straightforward route via 2-guanidino-5-b

ANTIPROLIFERATIVE QUINAZOLINES

Quinazoline compounds which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the growth and proliferation of the cells of higher organisms and microorganisms,such as bacteria, yeasts and fungi. Preferred quinazoline compounds are capable of inhibiting the enzyme thymidylate synthase. Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above

Design of thymidylate synthase inhibitors using protein crystal structures: The synthesis and biological evaluation of a novel class of 5- substituted quinazolinones

The design, synthesis, and biological evaluation of a new class of inhibitors of thymidylate synthase (TS) is described. The molecular design was carried out by a repetitive crystallographic analysis of protein-ligand structures. At the onset of this project, we focused on the folate cofactor binding site of a high-resolution ternary crystal complex of Escherichia coli TS, 5'-fluorodeoxyuridylate (5-FdUMP) and a classical glutamate-containing folic acid analog. A preliminary ternary crystal structure of a novel compound was successfully solved. Upon analysis of this initial complex, further structural elaborations were made, and a series of active 5- (arylthio)quinazolinones was developed. The synthetic strategy was based on the displacement of a halogen at the 5-position of a quinazolinone by various arylthioanions. The compounds were tested for inhibition of purified E. coli and/or human TS, and were assayed for cytotoxicity against three tumor cell lines in vitro. Significant thymidine protection effects were observed with several of the inhibitors, indicating that TS was the intracellular locus of activity.