14736-30-2

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Ethylchromone is used as a key intermediate in the synthesis of various pharmaceuticals for its versatile chemical structure and potential to be modified for specific therapeutic applications.
Used in Medicinal Chemistry Research:
2-Ethylchromone is used as a subject of study for its anticonvulsant, antioxidant, and antiproliferative properties, contributing to the development of new treatments for a variety of conditions.
Used in Drug Development:
2-Ethylchromone is used as a potential agent in drug development for its anti-inflammatory and neuroprotective properties, indicating its potential use in managing inflammatory diseases and neurodegenerative conditions.
Used in Antioxidant Applications:
2-Ethylchromone is used as an antioxidant agent for its ability to combat oxidative stress, which is implicated in many diseases and aging processes.
Used in Antiproliferative Applications:
2-Ethylchromone is used as an antiproliferative agent to inhibit the proliferation of cells, particularly in the context of cancer treatment to prevent tumor growth.
Used in Neuroprotection:
2-Ethylchromone is used as a neuroprotective agent to safeguard neurons from damage or degeneration, which is crucial in the treatment of neurological disorders.

InChI:InChI=1/C11H10O2/c1-2-8-7-10(12)9-5-3-4-6-11(9)13-8/h3-7H,2H2,1H3

Upstream product

• 35115-15-2 2-(propionylacetyl)phenol 
• 3739-97-7 (trimethylsilyl)methylenetriphenylphosphorane 
• 315241-12-4 C₁₀H₁₀O₄C₆H₁₄Si 
• 1040034-13-6 C₁₁H₁₁BrO₂ 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 118-93-4 o-hydroxyacetophenone 
• 1376543-77-9 C₁₇H₁₆O₃ 
• 97139-96-3 2'-propanoyloxyacetophenone 

Downstream Products

• 7734-61-4 2-ethyl-3,4-dihydro-2H-chromene 
• 136-81-2 2-pentylphenol 
• 65844-02-2 2-acetyl-4H-chromen-4-one 
• 4940-39-0 acide chromone carboxylique-2 
• 70423-63-1 2-(3-ethyl-isoxazol-5-yl)-phenol 
• 126411-98-1 5-ethyl-3-(2-hydroxyphenyl)-1-methylpyrazole 
• 126412-00-8 3-ethyl-5-(2-hydroxyphenyl)-1-methylpyrazole 
• 70423-64-2 1-acetoxy-2-(3-ethyl-isoxazol-5-yl)-benzene 

Relevant academic research and scientific papers

Synthesis of chiral chromanols: Via a RuPHOX-Ru catalyzed asymmetric hydrogenation of chromones

Chiral chromanols and their derivatives have been synthesized via a RuPHOX-Ru catalyzed asymmetric hydrogenation of chromones in high yields, >20:1 drs and with up to 99.9% ee. Control experiments show that the reaction undergoes two sequential asymmetric hydrogenation steps of the CC and CO double bonds. The reaction could be performed on a gram-scale with a relatively low catalyst loading (up to 1000 S/C), and the resulting products can be transformed to several biologically active compounds.

Ruthenium-NHC-catalyzed asymmetric hydrogenation of flavones and chromones: General access to enantiomerically enriched flavanones, flavanols, chromanones, and chromanols

Two to four! Readily available flavones and chromones were efficiently converted into four valuable chiral classes of O-heterocycles - flavanones, chromanones, flavanols, and chromanols - by means of an enantioselective Ru/NHC-catalyzed hydrogenation process (see scheme; NHC=N-heterocyclic carbene, PCC=pyridinium chlorochromate). Copyright

K2CO3-catalyzed synthesis of chromones and 4-quinolones through the cleavage of aromatic C-O bonds

Phenol-derived electrophiles are favorable substrates because phenols are naturally abundant or can be readily prepared from other aromatic compounds. However, the cleavage of aromatic C-O bonds is a great challenge because of their high energy. K2CO3-catalyzed intramolecular cyclization of 1-(2-alkoxyphenyl)-3-akylpropane-1,3-dione and 3-(alkylimino)-1-(2-methoxyphenyl)-2-methylpropan-1-one derivatives via the selective cleavage of aromatic C-O bonds is reported. The corresponding chromone and 4-quinolone derivatives were obtained in reasonable yields.

Transition-metal-free intramolecular Ullmann-type O-arylation: Synthesis of chromone derivatives

(Chemical Equation Presented) Expect the upexpected: A transition-metal- free approach to access chromone derivatives has been developed. The intramolecular O-arylation of substituted 1-(2-haloaryl)-propane-1,3-diones in DMF in the presence of K2CO3 gave the corresponding target products in good to excellent yields (see scheme; DMF = N,N′- dimethylformamide).

A Novel Synthesis of 4H-Chromen-4-ones via Intramolecular Wittig Reaction

formula presented The acylphosphoranes formed in a sequential manner from the reaction of the silyl ester of O-acyl(aroyl)salicylic acids and (trimethylsilyl)-methylenetriphenylphosphorane undergo intramolecular Wittig cyclization on the ester carbonyl to afford the 4H-chromen-4-ones in good to excellent yields.

A new metal complex promoted system for highly selective synthesis of 4H-chromen-4-ones (chromones)

Co(III)(salpr)(OH), a six coordinate cobalt Schiff base complex, promotes the highly selective conversion of 1-(o-hydroxyaryl)-1,3-diketones to 4H-chromen-4-ones under neutral conditions.