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Usage

Uses

Albuterol diMer is primarily used as an impurity in the pharmaceutical industry for the production of Albuterol (Salbutamol). It is essential to control the presence of this impurity to ensure the safety and efficacy of the final drug product.
Used in Pharmaceutical Industry:
Albuterol diMer is used as an impurity control agent for the production of Albuterol (Salbutamol), a medication used to treat asthma and other respiratory conditions. The presence of Albuterol diMer is monitored and controlled to maintain the quality and effectiveness of the final drug product.

Upstream product

• 67-56-1 methanol 
• 18559-94-9 Salbutamol 
• 39235-59-1 (2-benzyloxy-5-isopropenyl-phenyl)-methanol 
• 39235-58-0 4-hydroxy-3-hydroxymethylacetophenone 
• 99-93-4 4-Hydroxyacetophenone 

Relevant academic research and scientific papers

Synthesis of the impurity F of salbutamol

First synthesis of the diastereomeric mixture of salbutamol impurity F is described in seven steps by using 4-hydroxyacetophenone as starting material, with 15.2percent total yield. The synthesis provides access to multi-gram quantities of impurity F with good purity for reference supplies and further analytical and toxicology investigations. (Figure presented.).

Synthesis, isolation and characterization of process-related impurities in salbutamol sulphate

Three known and one unknown impurities in salbutamol sulphate bulk drug at level 0.1% (ranging from 0.05-0.1%) were detected by gradient reverse phase high performance liquid chromatography. These impurities were preliminarily identified by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the known and unknown imputities. Copyright E-Journal of Chemistry 2004-2011.