39235-59-1Relevant academic research and scientific papers
Synthesis of the impurity F of salbutamol
Song, Shu-Lian,Lian, Cheng-Xi,Chen, Li-Ping,Huang, Long-Liang
, p. 956 - 965 (2020)
First synthesis of the diastereomeric mixture of salbutamol impurity F is described in seven steps by using 4-hydroxyacetophenone as starting material, with 15.2percent total yield. The synthesis provides access to multi-gram quantities of impurity F with good purity for reference supplies and further analytical and toxicology investigations. (Figure presented.).
CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE
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, (2019/11/11)
The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a β2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.
Selective bromination of acetophenone derivatives with bromine in methanol
Goswami, Jonalee,Goswami, Amrit
, p. 469 - 471 (2007/10/03)
Acetophenone derivatives are selectively brominated in the acetyl side-chain with bromine in methanol at 0-5° by manipulating the electron density in the aromatic ring in good yield.
