147666-87-3

Basic information

• Product Name: 3-(3,4-dimethoxybenzylidene)-7-methoxy-2-benzofuran-1(3H)-one
• Synonyms: 3-(3,4-dimethoxybenzylidene)-7-methoxy-2-benzofuran-1(3H)-one
• CAS NO: 147666-87-3
• Molecular Formula: C₁₈H₁₆O₅
• Molecular Weight: 312.31664
• Mol File: 147666-87-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3,4-dimethoxybenzylidene)-7-methoxy-2-benzofuran-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dimethoxybenzylidene)-7-methoxy-2-benzofuran-1(3H)-one(147666-87-3)
• EPA Substance Registry System: 3-(3,4-dimethoxybenzylidene)-7-methoxy-2-benzofuran-1(3H)-one(147666-87-3)

Safety Data

• Hazardous Substances Data: 147666-87-3(Hazardous Substances Data)

Usage

General Description

3-(3,4-dimethoxybenzylidene)-7-methoxy-2-benzofuran-1(3H)-one, also known by its chemical formula C19H16O5, is a compound that belongs to the class of benzofuran derivatives. It is a yellow solid with a molecular weight of 324.33 g/mol. This chemical has potential biological properties and may exhibit medicinal activities such as antioxidant, anticancer, and anti-inflammatory effects. It is important to note that this compound should be handled with care, as its specific properties and potential applications are still under investigation by researchers.

Upstream product

• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 14963-96-3 3-methoxyphthalic anhydride 
• 127-09-3 sodium acetate 
• 73274-87-0 3-hydroxy-7-methoxy-3H-isobenzofuran-1-one 
• 1212-35-7 2-(3,4-dimethoxyphenyl)-N,N-dimethylacetamide 
• 6380-23-0 3,4-dimethoxystyrene 
• 579-75-9 2-Methoxybenzoic acid 
• 51674-10-3 N,N-diethyl-2-methoxybenzamide 
• 183619-72-9 2-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-6-methoxy-benzoic acid methyl ester 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 28281-58-5 7-methoxyisobenzofuran-1(3H)-one 
• 155005-24-6 8,3',4'-trimethylstilbene-2-carboxylic acid 
• 151698-58-7 N,N-diethyl-2-methoxy-6-[2-(3,4-dimethoxyphenyl)-1-oxoethyl]benzamide 
• 186581-53-3 diazomethane 

Downstream Products

• 147666-82-8 Thunberginol F 

Relevant articles and documents

One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless pd-catalyzed oxidative coupling of benzoic acids and vinylarenes

A straightforward synthetic method for the preparation of isocoumarins and 3-benzylidenephthalides via C-H olefination and oxidative coupling of readily available benzoic acids and vinylarenes was developed. The directing effect of the substituents on the benzoic acid allows for the synthesis of both types of lactone in pure form.

Synthesis of naturally occurring (Z)-3-benzylidenephthalide and (+/-) 3-benzylphthalides

A convenient method, involving generation of phthalide anion, is described for the synthesis of naturally occurring (Z) 3-benzylidenephthalide (5) and (+/-) 3-benzyl phthalides (6c, 10a-c), starting from phthalides (7a-b).

Development of bioactive functions in Hydrangeae Dulcis Folium. VI. Syntheses of thunberginols A and F and their 3'-deoxy-derivatives using regiospecific lactonization of stilbene carboxylic acid: Structures and inhibitory activity on histamine release of hydramacrophyllols A and B

Lactonization reaction of 2-carboxystilbene mediated by copper(II) chloride proceeded regiospecifically to give the five-membered lactone, while the bromolactonizations using N-bromosuccinimide and anodic oxidation were found to furnish the six-membered lactone. Using these regiospecific lactonization reactions as a key step, antiallergic and antimicrobial isocoumarins and the benzylidenephthalides thunberginols A and F and their 3'-deoxyanalogs were synthesized from phyllodulcin and hydrangenol. Two phthalides called hydramacrophyllols A and B were isolated from Hydrangeae Dulcis Folium and their stereostructures were determined on the basis of physicochemical and chemical evidence, which included the syntheses of hydramacrophyllols A and B from hydrangenol by the application of the lactonization method using copper(II) chloride. In addition, hydramacrophyllols A and B were found to exhibit an inhibitory effect on the histamine release from rat peritoneal exudate cells induced by antigen- antibody reaction.