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The Synthesis of Natural Acetylenic Compounds from Eutypa lata (Pers:F.) TUL.
Defranq, Eric,Zesiger, Thierry,Tabacchi, Raffaele
, p. 425 - 430 (1993)
The synthesis of a series of novel acetylenic compounds 1-7, isolated recently from the fungus Eutypa lata, is described.The crucial step is the coupling reaction between protected aryl halogenide and the acetylenic chain as a cuprous acetylide (Scheme I).A more efficient method using bis(triphenylphosphine)palladium dichloride () as catalyst was also carried out with success.
