The Synthesis of Natural Acetylenic Compounds from Eutypa lata (Pers:F.) TUL.

Article abstract of DOI:10.1002/hlca.19930760126

The synthesis of a series of novel acetylenic compounds 1-7, isolated recently from the fungus Eutypa lata, is described.The crucial step is the coupling reaction between protected aryl halogenide and the acetylenic chain as a cuprous acetylide (Scheme I).A more efficient method using bis(triphenylphosphine)palladium dichloride () as catalyst was also carried out with success.