147851-69-2

Basic information

• Product Name: (R)-2-phenoxypropionyl chloride
• Synonyms: (R)-2-phenoxypropionyl chloride
• CAS NO: 147851-69-2
• Molecular Weight: 184.622
• Mol File: 147851-69-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-2-phenoxypropionyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-phenoxypropionyl chloride(147851-69-2)
• EPA Substance Registry System: (R)-2-phenoxypropionyl chloride(147851-69-2)

Safety Data

• Hazardous Substances Data: 147851-69-2(Hazardous Substances Data)

Usage

General Description

(R)-2-phenoxypropionyl chloride is a chemical compound with the molecular formula C9H9ClO2. It is an organochlorine compound that is widely used in the synthesis of pharmaceuticals and agrochemicals. (R)-2-phenoxypropionyl chloride is a key building block in the production of various drugs and pesticides. It is also used as an intermediate in the manufacturing of fragrances and flavors. (R)-2-phenoxypropionyl chloride is a highly reactive compound that undergoes various chemical reactions to produce different derivatives with diverse applications in the chemical industry. It is important to handle this compound with caution due to its potential hazards and reactivity.

Upstream product

• 1129-46-0 (R)-(+)-2-phenoxypropionic acid 
• 940-31-8 2-phenoxypropionic acid 
• 106939-42-8 (S)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine 
• 122-35-0 2-phenoxypropanoic acid chloride 
• 108-95-2 phenol 

Downstream Products

• 106939-42-8 (S)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine 
• 112136-69-3 (R)-(+)-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine 
• 1129-46-0 (R)-(+)-2-phenoxypropionic acid 
• 200125-70-8 (S)-2-methyl-1,2,3,4-tetrahydroquinoline 
• 1780-19-4 (R)-1,2,3,4-tetrahydroquinaldine 
• 199186-69-1 (R)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline 
• 199186-68-0 (S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

Mutual Kinetic Resolution of Racemic 3,4-Dihydro-3-methyl-2H-[1,4]benzoxazines with Acyl Chlorides of Racemic O-Phenyllactic Acids and DFT Modelling of Transition States

The effect of the electronic nature of the para substituent on the aromatic ring of 2-aryloxypropionyl chlorides on the stereochemical outcome of the acylation of 3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and its 7,8-difluoro-containing analogue has been studied. The geometries of the diastereoisomeric transition states and the corresponding Gibbs free enthalpies of activation were determined through DFT calculations at the COSMO-CH2Cl2-B3LYP-D3-gCP/def2-TZVP (or def2-SVP)//B3LYP-D3-gCP/def2-SVP level of theory. It has been found that a low-cost quantum chemical calculation at a chosen level of theory describes well the quantitative dependence of the selectivity of acylation on the structures of the reagents. The obtained results indicate that aromatic interactions between the reagents play a significant role in the process of stereodifferentiation, ensuring high selectivity of the acylation of benzoxazines with 2-aryloxyacyl chlorides.

Derivatives of (R)-Lactic Acid for the Analysis of Chiral Alcohols by 1H NMR Spectroscopy

Diastereomeric esters of O-arylated (R)-lactic acids have been studied by 1H NMR spectroscopy with respect to their poptential application as reagents for chiral analysis.The substitution pattern of the acid moiety of the ester was found to have a decisiv