147851-69-2

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-phenoxypropionyl chloride is used as a key intermediate for the synthesis of various drugs. Its reactivity enables the creation of different drug derivatives, contributing to the development of novel pharmaceutical compounds.
Used in Agrochemical Industry:
In the agrochemical sector, (R)-2-phenoxypropionyl chloride is utilized as a vital component in the production of pesticides. Its role in synthesizing various agrochemicals aids in the development of effective pest control solutions.
Used in Fragrance and Flavor Industry:
(R)-2-phenoxypropionyl chloride is employed as an intermediate in the manufacturing of fragrances and flavors. Its ability to form different derivatives allows for the creation of a wide range of scents and tastes for various applications.
Used in Chemical Industry:
As a highly reactive compound, (R)-2-phenoxypropionyl chloride is used in the chemical industry to produce various derivatives. These derivatives find applications in multiple sectors, showcasing the versatility of this organochlorine compound.

Upstream product

• 108-95-2 phenol 
• 106939-42-8 (S)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine 
• 122-35-0 2-phenoxypropanoic acid chloride 
• 940-31-8 2-phenoxypropionic acid 
• 1129-46-0 (R)-(+)-2-phenoxypropionic acid 

Downstream Products

• 1164350-77-9 2-nitro-4-((R)-2-phenoxypropionylamino)benzoic acid 
• 106939-42-8 (S)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine 
• 112136-69-3 (R)-(+)-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine 
• 1129-46-0 (R)-(+)-2-phenoxypropionic acid 
• 200125-70-8 (S)-2-methyl-1,2,3,4-tetrahydroquinoline 
• 1780-19-4 (R)-1,2,3,4-tetrahydroquinaldine 

Relevant academic research and scientific papers

Mutual Kinetic Resolution of Racemic 3,4-Dihydro-3-methyl-2H-[1,4]benzoxazines with Acyl Chlorides of Racemic O-Phenyllactic Acids and DFT Modelling of Transition States

The effect of the electronic nature of the para substituent on the aromatic ring of 2-aryloxypropionyl chlorides on the stereochemical outcome of the acylation of 3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and its 7,8-difluoro-containing analogue has been studied. The geometries of the diastereoisomeric transition states and the corresponding Gibbs free enthalpies of activation were determined through DFT calculations at the COSMO-CH2Cl2-B3LYP-D3-gCP/def2-TZVP (or def2-SVP)//B3LYP-D3-gCP/def2-SVP level of theory. It has been found that a low-cost quantum chemical calculation at a chosen level of theory describes well the quantitative dependence of the selectivity of acylation on the structures of the reagents. The obtained results indicate that aromatic interactions between the reagents play a significant role in the process of stereodifferentiation, ensuring high selectivity of the acylation of benzoxazines with 2-aryloxyacyl chlorides.

Acylative kinetic resolution of racemic heterocyclic amines with (R)-2-phenoxypropionyl chloride

The acylative kinetic resolution of racemic heterocyclic amines such as 3,4-dihydro-3-methyl-2H-[1,4]benzoxazines, 3,4-dihydro-3-methyl-2H-[1,4]benzothiazine, 2-methyl-1,2,3,4-tetrahydro-quinolines and 2-methylindoline with enantiopure (R)-2-phenoxypropionyl chloride has been studied. It has been found that acylation of 3,4-dihydro-3-methyl-2H-[1,4]benzothiazine proceeds with the best stereoselectively when compared with other racemic amines. An efficient method for the preparation of (S)-3,4-dihydro-3-methyl-2H-[1,4]benzothiazine (99.4% ee) via a kinetic resolution protocol was developed. The possibility of recycling (R)-2-phenoxypropionic acid has been demonstrated.

Sweetening agent derived from L-aspartic or L-glutamic acid

The present invention relates to a novel sweetening agent and to its method of preparation. This novel sweetening agent is a 2-substituted acyl derivative of L-aspartic or L-glutamic acid and has the general formula STR1 R being an acyl group of the formu

Derivatives of (R)-Lactic Acid for the Analysis of Chiral Alcohols by 1H NMR Spectroscopy

Diastereomeric esters of O-arylated (R)-lactic acids have been studied by 1H NMR spectroscopy with respect to their poptential application as reagents for chiral analysis.The substitution pattern of the acid moiety of the ester was found to have a decisiv