148-87-8Relevant articles and documents
A high efficiency energy-saving environmental protection N - ethyl N - cyanoethyl aniline preparation method (by machine translation)
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Paragraph 0013-0034, (2017/04/28)
The invention is efficient energy-saving environmental protection N - ethyl N - cyanoethyl aniline preparation method, comprises a medium-pressure synthesis, and in the reaction, the addition reaction of the rectification and distillation, medium pressure in the synthesis, the alcohol, aniline and 1st catalyst into the medium-pressure in a reaction kettle, 1st catalyst by phosphorus oxychloride and copper-chromium according to weight ratio of 5:1 - 2 is mixed, after the reaction the crude product obtained after N - ethyl aniline rectification; in addition reaction, the N - ethyl aniline with catalyst third thin eyeball and 2nd input addition reaction kettle, 2nd catalyst is zinc chloride and copper-chromium according to weight ratio of 6:2 by mixing, reaction to the end of the N - ethyl N - cyanoethyl aniline crude distillation after. The invention further improves the N - ethyl N - cyanoethyl aniline reaction selectivity of; the other in reducing energy use and shorten the reaction time of the N - ethyl N - at the same time improve the selectivity of the cyanoethyl aniline. (by machine translation)
Assessment and use of two silicon carbide multi-well plates for library synthesis and proteolytic digests using microwave heating
Stencel, Lauren M.,Kormos, Chad M.,Avery, Keri B.,Leadbeater, Nicholas E.
experimental part, p. 2452 - 2457 (2009/09/26)
The use of two silicon carbide plates is reported for the preparation of three libraries of organic molecules using microwave heating. In addition, a preliminary study has been carried out, showing that one of the plates can also be used in a proteomics setting. Both the 24-position and 48-position plates heated evenly when irradiated with microwave energy. The 48-position plate was used to prepare a library of N-aryl functionalized β-amino esters via an aza-Michael reaction between anilines and Michael acceptors. The 24-position plate was used to prepare a library of biaryls via a Suzuki coupling methodology and a library of 1,4-dihydropyridines via a Hantzsch synthesis. The 48-position plate was also used to perform the proteolytic digestion of insulin chain B by trypsin. The Royal Society of Chemistry 2009.