3-Benzyl-5-(4-hydroxyphenyl)-2-pyrazine, a Photoreactive Analogue of Coelenteramide. Synthesis and Photolysis

Article abstract of DOI:10.1246/cl.1993.287

A photoreactive analogue of coelenteramide (light emitting species in aequorin bioluminescence) has been synthesized for photoaffinity labeling studies of aequorin.Photolysis of this compound in methanol gave a formal OH insertion product in 62percent yield without damage of the main skeleton of coelenteramide, indicating a potential use for mapping the coelenterazine binding site in aequorin.