1481-99-8

Basic information

• Product Name: SPIRO[5.5]UNDECANE-2,4-DIONE
• Synonyms: SPIRO[5.5]UNDECANE-2,4-DIONE;IFLAB-BB F2124-0756
• CAS NO: 1481-99-8
• Molecular Formula: C₁₁H₁₆O₂
• Molecular Weight: 180.24
• Mol File: 1481-99-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 317.6°Cat760mmHg
• Flash Point: 134.6°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 0.000181mmHg at 25°C
• Refractive Index: 1.498
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: SPIRO[5.5]UNDECANE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: SPIRO[5.5]UNDECANE-2,4-DIONE(1481-99-8)
• EPA Substance Registry System: SPIRO[5.5]UNDECANE-2,4-DIONE(1481-99-8)

Safety Data

• Hazardous Substances Data: 1481-99-8(Hazardous Substances Data)

Usage

Uses

Spiro[5.5]undecane-2,4-dione, is used as a reactant in the production of hydroxy-dimethyl-oxo-cyclohexenyl-dimethyl-tetrahydro-xanthenone which is an oral neuropeptide Y5 receptor antagonist.

InChI:InChI=1/C11H16O2/c12-9-6-10(13)8-11(7-9)4-2-1-3-5-11/h1-8H2

Upstream product

• 141-52-6 sodium ethanolate 
• 768-50-3 1-cyclohexenylacetone 
• 80385-43-9 2-cyclohexylideneacetyl chloride 
• 84189-13-9 cyclohexene-1-acetyl chloride 
• 108-94-1 cyclohexanone 
• 874-68-0 1-cyclohexylidene-2-propanone 
• 105-53-3 diethyl malonate 
• 412314-46-6 2,4-dioxo-spiro[5.5]undecane-1-carboxylic acid ethyl ester 
• 1552-91-6 cyclohexylideneacetic acid 

Downstream Products

• 24706-51-2 4-anilino-spiro[5.5]undec-3-en-2-one 
• 78380-96-8 2-Hydroxy-4-(4-methoxybenzoyloxy)-spiro<5.5>undeca-1,4-dien-3-on 
• 78380-94-6 3,3-Bis(4-methoxybenzoyloxy)spiro<5.5>undecan-2,4-dion 
• 57641-80-2 3-[N-(p-TOLUENESULFONYL)CARBAMOYL]SPIRO-[5.5]UNDECANE-2,4-DIONE 
• 1104812-24-9 10-(benzhydrylamino)-spiro[5.5]undec-9-en-8-one 
• 22728-00-3 1-(4-Chlorbenzolazo)-3-oxo-5,5-pentamethylen-cyclohexen-⁽¹⁾ 
• 6051-25-8 cyclohexan-1-acetic-1-carboxylic anhydride 
• 20127-08-6 2,2-pentamethylene-1,4-butanedicarboxylic acid 
• 78381-00-7 2,4-Bis(benzyloxycarbonyloxy)-spiro<5.5>undeca-1,4-dien-3-on 
• 78380-99-1 2-(Benzyloxycarbonyloxy)-4-hydroxy-spiro<5.5>undeca-1,4-dien-3-on 
• 78380-95-7 2-Benzoyloxy-4-hydroxy-spiro<5.5>undeca-1,4-dien-3-on 
• 76440-48-7 2-((p-tert-butylphenyl)thio)spiro<5.5>undecan-4-one 
• 871883-94-2 (1-acetonyl-cyclohexyl)-acetic acid 
• 4355-11-7 1,1-cyclohexanediacetic acid 

Relevant articles and documents

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.