148133-82-8

Basic information

• Product Name: 4-METHYLENEPIPERIDINE
• Synonyms: 4-METHYLENEPIPERIDINE;4-methylidenepiperidine
• CAS NO: 148133-82-8
• Molecular Formula: C₆H₁₁N
• Molecular Weight: 97.16
• Mol File: 148133-82-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 173-175℃
• Boiling Point: 121.2±9.0 °C(Predicted)
• Appearance: /
• Density: 0.86±0.1 g/cm3(Predicted)
• PKA: 10.40±0.20(Predicted)
• CAS DataBase Reference: 4-METHYLENEPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLENEPIPERIDINE(148133-82-8)
• EPA Substance Registry System: 4-METHYLENEPIPERIDINE(148133-82-8)

Safety Data

• Hazardous Substances Data: 148133-82-8(Hazardous Substances Data)

Usage

General Description

4-MethylenePiperidine is a chemical compound with the formula C7H13N. It’s commonly used as a reactive intermediate, typically in the synthesis of various chemical end products in the pharmaceutical and agriculture industries. Its high reactivity stems from a double bond located on the fourth carbon atom in the piperidine ring. This organic compound is classified as an alkene and an alicyclic compound, making it useful in a number of chemical reactions. However, it requires careful handling due to its hazardous nature.

Upstream product

• 140200-76-6 α,α'-dibromopentan-3-one 
• 626-58-4 4-methylpiperidin 
• 144230-50-2 4-methylenepiperidine monohydrochloride 
• 144282-55-3 ethyl 4-methylenepiperidine-1-carboxylate 
• 109105-86-4 N-benzyl-4-methylenepiperidine 
• 1445-73-4 1-Methyl-4-piperidone 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 63608-15-1 (4-(chloromethyl)piperidin-1-yl)(phenyl)methanone 
• 159635-49-1 tert-butyl 4-methylidenepiperidine-1-carboxylate 
• 188904-84-9 N-benzoyl-4-methylenepiperidine 

Downstream Products

• 530116-07-5 C₁₂H₁₄ClNO₂S 
• 164650-45-7 (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4-triazole-1-yl)-butane-2-ol 
• 3522-98-3 4-methylenepiperidine hydrobromide 
• 3522-98-3 4-methylenepiperidine hydrobromide 
• 147804-30-6 1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester 
• 1026519-37-8 4-[ethoxyimino-(4-trifluoromethoxy-phenyl)-methyl]-4'-methyl-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester 
• 305794-53-0 4'-methyl-4-(4-trifluoromethoxy-benzoyl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester 

Relevant articles and documents

Preparation method of 4-methylpiperidine salt

The invention relates to a preparation method of 4-methylpiperidine salt. According to the invention, 1,5-dihalide-3-pentanone is used as an initial raw material, through a wittig reaction, halogenated amine hydrolysis, salt forming with acid, the 4-methylpiperidine salt is obtained with high efficiency. The preparation method has the beneficial effects that the raw material source is wide, cost is low, operation is simple, a solvent is recycled and reused, the waste liquid discharge capacity is less, the product recovery rate is high, and industrialization is easily realized.

Development of a Robust Process for the Preparation of High-Quality 4-Methylenepiperidine Hydrochloride

An efficient route for the preparation of 4-methylenepiperidine hydrochloride 1 was designed, and then a process feasible for large-scale production was developed with a total yield of 83.5% at a purity of 99.9%.

Preparation of a spiroisoxazolinopiperidinylbenzamide-based scaffold

A route to spiroisoxazolinopiperidinylbenzamides has been developed. N-Boc-4-piperidone underwent a Wittig olefination and Boc-deprotection followed by a nucleophilic substitution reaction with 4-fluoro-3-nitrobenzoic acid to yield the starting scaffold 3