188904-84-9

Basic information

• Product Name: Piperidine, 1-benzoyl-4-methylene-
• CAS NO: 188904-84-9
• Molecular Formula: C13H15NO
• Molecular Weight: 201.268
• Mol File: 188904-84-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-benzoyl-4-methylene-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-benzoyl-4-methylene-(188904-84-9)
• EPA Substance Registry System: Piperidine, 1-benzoyl-4-methylene-(188904-84-9)

Safety Data

• Hazardous Substances Data: 188904-84-9(Hazardous Substances Data)

Usage

General Description

Piperidine, 1-benzoyl-4-methylene- is a chemical compound with the molecular formula C13H13NO. It is a derivative of piperidine, a heterocyclic amine commonly used as a building block in organic synthesis. The benzoyl group is a functional group consisting of a benzene ring bonded to a carbonyl group, adding reactivity and stability to the molecule. The presence of the methylene group introduces a double bond, which further increases the compound's reactivity. This chemical is used in the production of pharmaceuticals, agrochemicals, and other organic compounds. It is important to handle this compound with caution, as it may pose health and environmental risks.

Upstream product

• 63608-15-1 (4-(chloromethyl)piperidin-1-yl)(phenyl)methanone 

Downstream Products

• 148133-82-8 4-methylene piperidine 
• 164650-45-7 (2R*,3R*)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidino)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 164650-45-7 (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4-triazole-1-yl)-butane-2-ol 
• 164650-45-7 (2S,3S)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 65-85-0 benzoic acid 

Relevant articles and documents

Synthesis and antifungal activities of (2R,3R)-2-aryl-1-azolyl-3- (substituted amino)-2-butanol derivatives as topical antifungal agents

2-Aryl-1-azolyl-3-(substituted amino)-2-butanol derivatives I were prepared by ring-opening reaction of epoxides II with excess amine, and their antifungal activities were evaluated as topical agents. Azolyl-cyclic amine derivatives with a methylene group showed extremely strong activity with a broad spectrum in vitro. In general, anti-Trichophyton mentagrophytes activities of most of the topical antifungal agents are substantially reduced by addition of keratin (a major constituent of the keratinized tissue). However, the triazole derivative (2R,3R)-2-(2,4-difluorophenyl)-3-(4- methylenepiperidino)-1-(1H-1,2,4-triazol-1-yl)-2-butanol ((-)-40, KP-103) showed very little deactivation by addition of keratin. This biological characteristic of triazole derivative (-)-40 resulted in excellent therapeutic efficacy on dermatophytosis superior to that of the corresponding imidazole derivative ((-)-41).