63608-15-1

Basic information

• Product Name: Piperidine, 1-benzoyl-4-(chloromethyl)-
• CAS NO: 63608-15-1
• Molecular Formula: C13H16ClNO
• Molecular Weight: 237.729
• Mol File: 63608-15-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-benzoyl-4-(chloromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-benzoyl-4-(chloromethyl)-(63608-15-1)
• EPA Substance Registry System: Piperidine, 1-benzoyl-4-(chloromethyl)-(63608-15-1)

Safety Data

• Hazardous Substances Data: 63608-15-1(Hazardous Substances Data)

Upstream product

• 626-58-4 4-methylpiperidin 
• 98-88-4 benzoyl chloride 
• 19980-00-8 1-benzoyl-4-hydroxymethyl-piperidine 

Downstream Products

• 188904-84-9 N-benzoyl-4-methylenepiperidine 
• 63608-14-0 N-benzoyl-4-phenoxymethylpiperidine 
• 204639-64-5 2-[(2-hydroxy-ethyl)-(1-benzoyl-piperidin-4-yl-methyl)-amino]-ethanol 
• 164650-45-7 (2R*,3R*)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidino)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 164650-45-7 (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4-triazole-1-yl)-butane-2-ol 
• 164650-45-7 (2S,3S)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 148133-82-8 4-methylene piperidine 

Relevant articles and documents

Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate

This letter describes the development of a method for selective remote C(sp3)-H oxygenation of protonated aliphatic amines using aqueous potassium persulfate. Protonation serves to deactivate the proximal C(sp3)-H bonds of the amine substrates and also renders the amines soluble in the aqueous medium. These reactions proceed under relatively mild conditions (within 2 h at 80 °C with amine as limiting reagent) and do not require a transition metal catalyst. This method is applicable to a variety of types of C(sp3)-H bonds, including 3°, 2°, and benzylic C-H sites in primary, secondary, and tertiary amine substrates.

4-Phenoxymethyl-piperidines

4-Phenoxymethyl-piperidines of the formula STR1 wherein R is hydrogen, halogen, nitro, lower alkyl or lower alkoxy, in the form of the free base or an acid addition salt, are provided and they are useful as intermediates in the production of anti-hypertensive agents through condensation with (a) propyl chloride and then with an adenine, or (b) a propyl indole.