148235-40-9

Basic information

• Product Name: Benzoic acid, 4-methoxy-3-(phenylmethoxy)-, phenylmethyl ester
• CAS NO: 148235-40-9
• Molecular Formula: C22H20O4
• Molecular Weight: 348.398
• Mol File: 148235-40-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-methoxy-3-(phenylmethoxy)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-methoxy-3-(phenylmethoxy)-, phenylmethyl ester(148235-40-9)
• EPA Substance Registry System: Benzoic acid, 4-methoxy-3-(phenylmethoxy)-, phenylmethyl ester(148235-40-9)

Safety Data

• Hazardous Substances Data: 148235-40-9(Hazardous Substances Data)

Upstream product

• 645-08-9 Isovanillic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 60547-95-7 4-methoxy-5-benzyloxy-2-aminobenzamide 
• 60547-93-5 4-methoxy-5-benzyloxy-2-nitrobenzamide 
• 911418-44-5 4-methoxy-5-benzyloxy-2-(3-nitrobenzoylamino)benzamide 
• 911418-45-6 6-(benzyloxy)-7-methoxy-2-(3-nitrophenyl)quinazolin-4(3H)-one 
• 911418-43-4 6-hydroxy-7-methoxy-2-(3-nitrophenyl)quinazolin-4(3H)-one 
• 55667-12-4 4-methoxy-3-(benzyloxy)benzyl bromide 
• 116518-95-7 <3-(benzyloxy)-4-methoxybenzyl>triphenylphosphonium bromide 
• 1860-60-2 3-benzyloxy-4-methoxy-benzyl alcohol 
• 58452-00-9 3-benzyloxy-4-methoxybenzoic acid 
• 634197-88-9 4-(6-benzyloxy-7-methoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide 
• 634197-93-6 {4-[4-(4-cyano-phenylcarbamoyl)-piperazin-1-yl]-7-methoxy-quinazolin-6-yloxy}-acetic acid methyl ester 

Relevant articles and documents

A concise and efficient synthesis of tetrahydroquinoline alkaloids using the phase transfer mediated Wittig olefination reaction

The present study describes the total synthesis of 1,2,3,4-tetrahydroquinoline alkaloids (±)-galipinine, (±)-cuspareine, (±)-galipeine and (±)-angustureine, in three steps and high yields (78%, 76%, 74%, and 66%, respectively) from common aldehyde and the ylide respectives. The key step of this approach is based on an unusual Wittig reaction by using the phase transfer medium (aq. NaOH/CH2Cl2 1:1 or t-BuOK/t-BuOH/CH2Cl2 1:1), affording olefinic intermediates in high yields.

RHO KINASE INHIBITORS

The present invention relates to inhibitors of ROCK1 and ROCK2, which may be selective for ROCK2, and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and/or ROCK2. Also provided are treatments combining inhibitors of ROCK1 and/or ROCK2 with statins.

PHARMACOKINETICALLY IMPROVED COMPOUNDS

The present invention relates to inhibitors of ROCKl and R0CK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCKl and or R0CK2 that are useful for the treatment of disease.