148345-20-4

Usage

Uses

Used in Pharmaceutical Industry:
Benzenepropanoic acid, a-[(4-nitrophenyl)methylene]-b-oxo-, ethyl ester, (Z)is used as a potential active pharmaceutical ingredient for the development of new drugs. Its unique structure and functional groups may offer novel therapeutic properties, such as anti-inflammatory, analgesic, or antimicrobial effects. Further research is needed to explore its pharmacological potential and optimize its efficacy and safety profile.
Used in Chemical Industry:
In the chemical industry, Benzenepropanoic acid, a-[(4-nitrophenyl)methylene]-b-oxo-, ethyl ester, (Z)may serve as an intermediate or building block in the synthesis of more complex organic compounds. Its reactivity and functional groups can be exploited in various chemical reactions, such as esterification, hydrolysis, or condensation, to produce a wide range of products with diverse applications, including agrochemicals, dyes, or specialty chemicals.
Used in Research and Development:
Benzenepropanoic acid, a-[(4-nitrophenyl)methylene]-b-oxo-, ethyl ester, (Z)can be utilized as a research compound in academic and industrial laboratories. Its unique structure and properties make it a valuable tool for studying various chemical and biological phenomena, such as enzyme inhibition, receptor binding, or molecular recognition. Additionally, it can be employed as a reference standard or analytical control in the development and validation of analytical methods for the detection and quantification of related compounds.
ester, (Z)-'s safety, environmental impact, and regulatory status should be carefully considered before its implementation in any industry.

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 64967-44-8 (Z)-ethyl 3-acetyloxy-3-phenyl-2-propenoate 
• 555-16-8 4-nitrobenzaldehdye 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 16089-71-7 (Z)-N-(4-nitrobenzylidene)methylamine N-oxide 
• 148345-15-7 4-ethoxycarbonyl-2-methyl-3-(4'-nitrophenyl)-5-phenyl-4-isoxazoline 
• 74-88-4 methyl iodide 

Downstream Products

• 105199-59-5 C₄₂H₂₈N₆O₈S₂ 
• 105199-49-3 (2S,3R,4S)-5-Cyano-2-hydroxy-6-methylsulfanyl-4-(4-nitro-phenyl)-2-phenyl-1,2,3,4-tetrahydro-pyridine-3-carboxylic acid ethyl ester 
• 105199-69-7 5-Cyano-6-methylsulfanyl-4-(4-nitro-phenyl)-2-phenyl-nicotinic acid ethyl ester 
• 105199-54-0 5-Cyano-4-(4-nitro-phenyl)-2-phenyl-6-thioxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester 
• 793683-49-5 6-carbamoylmethylsulfanyl-5-cyano-2-hydroxy-4-(4-nitro-phenyl)-2-phenyl-1,2,3,4-tetrahydro-pyridine-3-carboxylic acid ethyl ester 
• 105199-44-8 Sodium; (4R,5S,6R)-3-cyano-5-ethoxycarbonyl-6-hydroxy-4-(4-nitro-phenyl)-6-phenyl-1,4,5,6-tetrahydro-pyridine-2-thiolate 

Relevant academic research and scientific papers

Enzyme Promiscuity as a Remedy for the Common Problems with Knoevenagel Condensation

A new protocol based on lipase-catalyzed tandem reaction toward α,β-enones/enoesters is presented. For the synthesis of the desired products the tandem process based on enzyme-catalyzed hydrolysis and Knoevenagel reaction starting from enol acetates and aldehyde is developed. The relevant impact of the reaction conditions including organic solvent, enzyme type, and temperature on the course of the reaction was revealed. It was shown that controllable release of the active methylene compound from the corresponding enol carboxylate ensured by enzymatic reaction diminishes significantly the formation of the unwanted co-products. Furthermore, this protocol was extended by including a second tandem chemoenzymatic transformation engaging various aldehyde precursors. After a careful optimization of the reaction conditions, the target products were obtained with yields up to 86 % and with excellent E/Z-selectivity.

Synthesis of Ethyl 2-Aminodihydro-5-pyrimidinecarboxylate Derivatives and 3,7-Diethoxycarbonyl-4,6-dihydro-2,4,6,8-tetraaryl-lH-pyrimido[1,2-a]pyrimidines

Reactions of ethyl 3-aryl-2-benZoylpropenoateS 1 with guanidine and N-alkyl(or benzyl)guanidines have been investigated. Ethyl 2-aminodihydro-5-pyrimidinecarboxylate derivatives 3, 4 or 5 and 3,7-diethoxycarbonyl-4,6-dihydro-2,4,6,8-tetraaryl-lH-pyrimido[

RING-OPENING OF 4-ISOXAZOLINES: COMPETITIVE FORMATION OF ENAMINO DERIVATIVES AND α,β-ENONES

Ring-opening of 3-substituted 4-isoxazolines, proceeding through the intermediate isoxazolinium salts, follows two competing reaction pathways leading to α,β-enones and enamines respectively.The rearrangement courses can be controlled as a function of substitution pattern and experimental conditions.