148550-52-1

Upstream product

• 52670-38-9 2-ethynylaniline 
• 541-41-3 chloroformic acid ethyl ester 
• 98952-64-8 N-ethoxycarbonyl-2-iodoaniline 
• 104919-70-2 ethyl (2-bromophenyl)carbamate 
• 1448422-99-8 ethyl (2-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl)carbamate 
• 64-17-5 ethanol 
• 1207252-50-3 2-ethynylbenzylamide 
• 104919-71-3 ethyl N-[2-(trimethylsilylethynyl)phenyl]carbamate 

Downstream Products

• 404034-63-5 3-[(2-ethoxycarbonylamino)phenylethynyl]-2-isopropenylfuran 
• 1009309-18-5 methyl 5-amino-4-{[2-(ethoxycarbonylamino)phenyl]ethynyl}-7-methyl-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate 
• 120-72-9 indole 
• 1165795-65-2 ethyl (E)-3-benzylidene-3,4-dihydro-4-oxo-2-phenylquinoline-1(2H)-carboxylate 
• 13307-67-0 ethyl 1H-indole-1-carboxylate 
• 148550-54-3 2-[Ethoxycarbonyl-(2-ethynyl-phenyl)-amino]-pyrimidine-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

K3PO4-KOH mixture as efficient reagent for the deprotection of 4-aryl-2-methyl-3-butyn-2-ols to terminal acetylenes

A mixture of potassium hydroxide and potassium phosphate was found to be an active reagent mixture for the cleavage of 2-hydroxypropyl-protected acetylenes. The reaction was performed in toluene at reflux temperature and gave terminal acetylenes in good to excellent yields within very short periods of time. Numerous other functional groups are tolerated. Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for full experimental and spectral details.

One-pot approach to 2,3-disubstituted-2,3-dihydro-4-quinolones from 2-alkynylbenzamides

Concise and efficient syntheses of various trans-2,3-disubstituted-2,3- dihydro-4-quinolones have been achieved via tandem Hofmann-type rearrangement of 2-alkynylbenzamides, nucleophilic addition of alcohols to the isocyanate intermediates, intermolecular

Development of an Efficient Procedure for Indole Ring Synthesis from 2-Ethynylaniline Derivatives Catalyzed by Cu(II) Salts and Its Application to Natural Product Synthesis

The development of efficient methods for the indole synthesis catalyzed by Cu(II) salts and its applications were investigated. Cu(OAc)2 has been proved to be the best catalyst for the synthesis of various 1-p-tolylsulfonyl or 1-methylsulfonylindoles, which have both electron-withdrawing and electron-donating groups on the aromatic ring and C2 position of indoles. For the primary aniline derivatives, Cu(OCOCF 3)2 showed good activities, while Cu(OAc)2 was a good catalyst for the cyclization of secondary anilines. This methodology could be applied to the sequential cyclization reaction for the compounds which have the electrophilic part in the same molecule. By prior treatment with KH, the sequential cyclization was realized to provide the tricyclic ring systems, but it was limited to five- and six-membered rings for the second cyclization. Finally, formal and total synthesis of hippadine with the Cu(II)-promoted indole synthesis as the key step was accomplished.

An efficient synthesis of α-carboline-3-carboxylic acid, ethyl ester (α-CCE)

The use of the Intramolecular Inverse Electron Demand Diels-Alder reaction between an acetylenic dienophile and a pyrimidine diene component is described in the synthesis of α-CCE.