148582-48-3Relevant academic research and scientific papers
New practical synthesis of 5-formylindole
Fetter, Jozsef,Bertha, Ferenc,Poszavacz, Laszlo,Simig, Gyula
, p. 137 - 139 (2007/10/03)
5-Formylindole (2) was synthesized in good overall yield starting from 3-methyl-4-nitrobenzaldehyde (4) by utilization of the Batcho-Leimgruber indole synthesis.
Alkylation of nitroarenes with Grignard reagents via oxidative nucleophilic substitution of hydrogen
Ma?kosza, Mieczys?aw,Surowiec, Marek
, p. 167 - 171 (2007/10/03)
Alkylation of nitroarenes with Grignard reagents via oxidative nucleophilic substitution of hydrogen (ONSH) can be efficiently executed with potasium permanganate in liquid ammonia as an oxidative system for the σH adducts. The addition of RMgX to ArNO2 of stoichiometry 1:1 is accompanied with a redox process apparently of stoichiometry 2:1. Because of that, real stoichiometry of the reaction between nitroarenes and Grignard reagents is ca. 1:1.5.
Conjugate addition of Grignard reagents to para-substituted nitrobenzenes
Bentley, Stephen J.,Milner, David J.
, p. 1 - 3 (2007/10/02)
Nitrobenzenes bearing masked aldehyde, ketone and ketoester functions at the 4-position undergo conjugate addition with Grignard reagents in THF at -15 deg C.Sequential treatment of the 4-substituted nitrobenzenes with primary or secondary alkyl magnesium
