1486-57-3Relevant articles and documents
Synthesis of quercetin glycosides and their α-glucosidase inhibitory activities
Xu, Bixue,Liang, Guangyi,Wen, Zhonghang,Hu, Zhanxin,Yuan, Jie,Chen, Hongju,Zhang, Limei
, p. 1245 - 1260 (2016)
A series of quercetin glycosides as the analogues of 3,5,5'- Trimethyl-7-O-β-D-glucopyranosylquercetin (8) were synthesized, their structures were confirmed by 1H NMR, 13C NMR and MS. The inhibitory activities of those compounds against α-glucosidase were evaluated in vitro, in particular, the compounds V-c and V-d-2 showed promising bioactivities with IC50 of 19.4 μmol·L-1 and 19.7 μmol·L-1, are much higher than 8 (IC50 > 100 μmol·L-1). This research will provide a reference in the study of the synthetic methods and hypoglycemic activity for the quercetin glycosides.
Flavone glycoside derivatives, and preparation method and application thereof
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, (2016/10/08)
The invention discloses flavone glycoside derivatives which are compounds with a general structural formula I shown in the description, and pharmaceutically acceptable salts or hydrates thereof, including racemates, optical isomers and epimers of the deri
Discovery of metal ions chelator quercetin derivatives with potent anti-HCV activities
Zhong, Dongwei,Liu, Mingming,Cao, Yang,Zhu, Yelin,Bian, Shihui,Zhou, Jiayi,Wu, Fengjie,Ryu, Kum-Chol,Zhou, Lu,Ye, Deyong
, p. 6978 - 6999 (2015/05/13)
Analogues or isosteres of α,γ-diketoacid (DKA) 1a show potent inhibition of hepatitis C virus (HCV) NS5B polymerase through chelation of the two magnesium ions at the active site. The anti-HCV activity of the flavonoid quercetin ( 2) could partly be attri
