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5-Thiazolecarbonyl chloride, 2-chloro(9CI) is a chemical compound belonging to the thiazolecarbonyl chloride family. It is a colorless or light yellow clear liquid with a pungent odor, known for its versatility as an intermediate in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, dyes, and pigments.

148637-74-5

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148637-74-5 Usage

Uses

Used in Pharmaceutical Industry:
5-Thiazolecarbonyl chloride, 2-chloro(9CI) is used as a reagent in the synthesis of various thiazole-containing compounds, which have applications in medicine. These compounds are often found in the development of new drugs due to their unique chemical properties and potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Thiazolecarbonyl chloride, 2-chloro(9CI) serves as a key intermediate in the production of compounds used in agriculture, such as pesticides and herbicides, to help protect crops and enhance agricultural productivity.
Used in Dye and Pigment Production:
5-Thiazolecarbonyl chloride, 2-chloro(9CI) is also utilized as an intermediate in the synthesis of dyes and pigments, contributing to the coloration and appearance of various products in industries such as textiles, plastics, and printing.
It is crucial to handle 5-Thiazolecarbonyl chloride, 2-chloro(9CI) with care due to its corrosive nature, which can cause skin, eye, and respiratory irritation upon contact. Proper safety measures should be taken during its use to ensure the well-being of individuals and the environment.

Check Digit Verification of cas no

The CAS Registry Mumber 148637-74-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,6,3 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 148637-74:
(8*1)+(7*4)+(6*8)+(5*6)+(4*3)+(3*7)+(2*7)+(1*4)=165
165 % 10 = 5
So 148637-74-5 is a valid CAS Registry Number.
InChI:InChI=1/C4HCl2NOS/c5-3(8)2-1-7-4(6)9-2/h1H

148637-74-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-1,3-thiazole-5-carbonyl chloride

1.2 Other means of identification

Product number -
Other names 5-Thiazolecarbonylchloride,2-chloro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:148637-74-5 SDS

148637-74-5Relevant articles and documents

VECTOR CONTROL COMPOSITIONS, METHODS AND PRODUCTS UTILIZING SAME

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Page/Page column 42; 43; 44, (2019/05/15)

The present inventions concerns use of a specific methoxyacrylate compound to control mosquitoes, and vector control products comprising that methoxyacrylate compound, in particular the invention relates to a substrate, to a composition, for controlling mosquitoes, and to a specific methoxyacrylate compound, processes for the synthesis of mosquitocidal methoxyacrylate compounds and new intermediates.

Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD)

Palmer, Nick,Peakman, Torren M.,Norton, David,Rees, David C.

, p. 1599 - 1610 (2016/02/10)

This study describes general synthesis aspects of fragments for FBDD, as illustrated by the dihydroisoquinolones 1-3. Previous Rh(iii) methodology is extended to incorporate amines, heteroatoms (N and S), and substituents (halogen, ester) as potential binding groups and/or synthetic growth points for fragment-to-lead elaboration.

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N′-arylpiperazine series

Nishimura, Nobuko,Norman, Mark H.,Liu, Longbin,Yang, Kevin C.,Ashton, Kate S.,Bartberger, Michael D.,Chmait, Samer,Chen, Jie,Cupples, Rod,Fotsch, Christopher,Helmering, Joan,Jordan, Steven R.,Kunz, Roxanne K.,Pennington, Lewis D.,Poon, Steve F.,Siegmund, Aaron,Sivits, Glenn,Lloyd, David J.,Hale, Clarence,St. Jean, David J.

, p. 3094 - 3116 (2014/05/06)

We have recently reported a novel approach to increase cytosolic glucokinase (GK) levels through the binding of a small molecule to its endogenous inhibitor, glucokinase regulatory protein (GKRP) these initial investigations culminated in the identification of 2-(4-((2S)-4-((6-amino-3- pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3, 3-hexafluoro-2-propanol (1, AMG-3969), a compound that effectively enhanced GK translocation and reduced blood glucose levels in diabetic animals. Herein we report the results of our expanded SAR investigations that focused on modifications to the aryl carbinol group of this series. Guided by the X-ray cocrystal structure of compound 1 bound to hGKRP, we identified several potent GK-GKRP disruptors bearing a diverse set of functionalities in the aryl carbinol region. Among them, sulfoximine and pyridinyl derivatives 24 and 29 possessed excellent potency as well as favorable PK properties. When dosed orally in db/db mice, both compounds significantly lowered fed blood glucose levels (up to 58%).

HETEROCYCLIC AMINO BERBAMINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF

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Paragraph 0095; 0099, (2013/07/25)

The present invention relates to a novel berbamine derivative of formula I or a pharmaceutically acceptable salt thereof, a process for preparation of the same, a pharmaceutical composition comprising said compound and its use in manufacture of an antitumor medicament.

HETEROCYCLIC AMINOBERBAMINE DERIVATIVES, THE PREPARATION PROCESS AND USE THEREOF

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Paragraph 0108, (2013/07/19)

The present invention relates to a novel berbamine derivative of formula I or a pharmaceutically acceptable salt thereof, a process for preparation of the same, a pharmaceutical composition comprising said compound and its use in manufacture of an antitumor medicament.

SYNTHESIS OF HALOGENATED THIAZOLE DERIVATIVES OF OLIGO-N-METHYLPYRROLECARBOXAMIDE AND THEIR PHOTOCHEMICAL DNA CLEAVING ACTIVITIES

Sakai, Yasuhiro,Matsumoto, Toyomi,Tanaka, Akie,Shibuya, Masayuki

, p. 565 - 573 (2007/10/02)

Synthesis of various halogenated thiazole derivatives of oligo-N-methylpyrrolecarboxamide and their DNA cleaving activities under UV-A irradiation were described.

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