81449-93-6

Basic information

• Product Name: ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE
• Synonyms: ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE;Ethyl 2-chloro-5-thiazolecarboxylate;ethyl 2-chloro-1,3-thiazole-5-carboxylate;5-Thiazolecarboxylicacid, 2-chloro-, ethyl ester;2-Chloro-5-thiazolecarboxylic acid ethyl ester;2-Chlorothiazole-5-carboxylic acid ethyl ester
• CAS NO: 81449-93-6
• Molecular Formula: C₆H₆ClNO₂S
• Molecular Weight: 191.63534
• Mol File: 81449-93-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 283.9 °C at 760 mmHg
• Flash Point: 125.5 °C
• Appearance: /
• Density: 1.383 g/cm³
• Vapor Pressure: 0.00307mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Chloroform; Dichloromethane; DMSO; Ethyl Acetate
• PKA: -0.98±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE(81449-93-6)
• EPA Substance Registry System: ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE(81449-93-6)

Safety Data

• Hazardous Substances Data: 81449-93-6(Hazardous Substances Data)

Usage

Uses

Ethyl 2-chlorothiazole-5-carboxylate is an intermediate in synthesizing 2-Chloro-5-thiazolecarboxylic Acid (C411465). It was studied as one of the metabolites of thiamethoxam, clothianidin, and dinotefuran in mice.

InChI:InChI=1/C6H6ClNO2S/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3

Upstream product

• 32955-21-8 2-amino-thiazole-5-carboxylic acid ethyl ester 
• 79265-30-8 2-(trimethylsilyl)thiazole 
• 541-41-3 chloroformic acid ethyl ester 
• 1001-26-9 ethyl 3-ethoxyacrylate 
• 64-17-5 ethanol 
• 148637-74-5 2-chloro-1,3-thiazole-5-carbonyl chloride 

Downstream Products

• 101012-12-8 2-chloro-1,3-thiazole-5-carboxylic acid 
• 56355-51-2 ethyl 2-phenoxy-thiazole-5-carboxylate 
• 867065-53-0 4-(4-ethoxycarbonylthiazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester 
• 1254969-77-1 2-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-thiazole-5-carboxylic acid ethyl ester 

Relevant articles and documents

HETEROCYCLIC AMINO BERBAMINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF

The present invention relates to a novel berbamine derivative of formula I or a pharmaceutically acceptable salt thereof, a process for preparation of the same, a pharmaceutical composition comprising said compound and its use in manufacture of an antitumor medicament.

OPIOID RECEPTOR ANTAGONISTS

A compound of the formula I: (I) wherein the variables are as described herein, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixture thereof, formulations and methods of use thereof are disclosed.

SYNTHESIS OF HALOGENATED THIAZOLE DERIVATIVES OF OLIGO-N-METHYLPYRROLECARBOXAMIDE AND THEIR PHOTOCHEMICAL DNA CLEAVING ACTIVITIES

Synthesis of various halogenated thiazole derivatives of oligo-N-methylpyrrolecarboxamide and their DNA cleaving activities under UV-A irradiation were described.