777944-33-9

Upstream product

• 87768-46-5 N-[(1S)-1-(methoxymethyl)-2-methylpropyl]benzamide 
• 207509-50-0 3-{[3,5-bis(trifluoromethyl)benzyl]oxy}pyridine 
• 109-00-2 3-HYDROXYPYRIDINE 
• 32247-96-4 3,5-bis(trifluoromethyl)benzyl bromide 

Downstream Products

• 777944-34-0 N-(1E)-[(2R,3R)-3-{[3,5-bis(trifluoromethyl)benzyl]oxy}-2-phenyl-piperidin-1-yl]-N-[(S)-2-(1-methoxy-3-methylbutyl)]-benzamidine 
• 148700-91-8 L 733061 

Relevant academic research and scientific papers

Nucleophilic addition to 3-substituted pyridinium salts: Expedient syntheses of (-)-L-733,061 and (-)-CP-99,994

(Chemical Equation Presented) The addition of nucleophiles to 3-substituted pyridinium salts prepared from N-methylbenzamide and various pyridines has been investigated. Good to excellent regioselectivities favoring the 2,3-disubstituted 1,2-dihydropyridines were observed. The resulting 1,2-dihydropyridines led to the corresponding 2,3-disubstituted pyridines upon treatment with Mn(OAc)3/NaIO4. This methodology was also successfully applied to the enantioselective syntheses of (-)-L-733,061 and (-)-CP-99,994, two members of a new class of highly potent, nonpeptide, Substance P antagonists.