148726-12-9Relevant academic research and scientific papers
An Unconvertional Synthetic Approach to Fluoro Heteroaromatic Compounds by a Novel Transformation of an Anionically Activated Trifluoromethyl Group
Kiselyov, Alexander S.,Strekowski, Lucjan
, p. 7597 - 7600 (1994)
Lithium reagents derived from acetophenone, phenylacetylene, and substituted acetonitriles undergo a reaction with 2-(trifluoromethyl)aniline (1) to give the corresponding 4-fluoroquinolines 8, 10a-d.A related reaction of 2-benzothienyllithium with 2-(
The o-Amino-Trifluoromethyl Functionality as a Novel Synthon for 4-Fluoroquinolines
Strekowski, Lucjan,Kiselyov, Alexander S.,Hojjat, Maryam
, p. 5886 - 5890 (2007/10/02)
2-Substituted 4-fluoroquinolines 3 are obtained by the reaction of 2-(trifluoromethyl)aniline (1) with lithium enolates 2 derived from methyl ketones.A similar reaction of 1 with lithium enolate of acetaldehyde produces 4-fluoroquinoline. 1-Fluoro-3-phenyl-4,6-phenanthroline (18) is obtained by treatment of lithium enolate of acetophenone with 4-(trifluoromethyl)quinolin-3-amine (17).By contrast, (Z)-N-carboxamides 10 and 12 are the products of the reaction of 1 with the respective enolate ions derived from 3-pentanone and isobutyl phenyl ketone.A unified mechanism for the formation of quinolines and carboxamides is proposed.
Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-HIV-1 agents
Strekowski,Mokrosz,Honkan,Czarny,Cegla,Wydra,Patterson,Schinazi
, p. 1739 - 1746 (2007/10/02)
Thirty-eight 2-(aryl or heteroaryl)quinolin-4-amines, N,N-disubstituted, N-monosubstituted, and without a substituent at the amino group have been synthesized with use of novel chemistries developed by us recently. Some of these derivatives show anti-HIV-
