148901-61-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(2'-cyanophenoxy)-4-nitrobenzene is used as a synthetic intermediate for the production of pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs with specific therapeutic properties.
Used in Dye Industry:
In the dye industry, 1-(2'-cyanophenoxy)-4-nitrobenzene is used as an intermediate for synthesizing various dyes. Its chemical composition contributes to the color and stability of the dyes produced.
Used in Agrochemical Industry:
1-(2'-cyanophenoxy)-4-nitrobenzene is also utilized as an intermediate in the agrochemical industry. It plays a role in the synthesis of compounds used in the development of pesticides and other agricultural chemicals, which are essential for crop protection and increased yield.

Upstream product

• 100-02-7 4-nitro-phenol 
• 394-47-8 2-fluorobenzonitrile 
• 611-20-1 salicylonitrile 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 868697-63-6 C₃₇H₃₉N₅O₈ 
• 868697-65-8 C₃₃H₃₆N₃O₇P 
• 868697-61-4 C₃₁H₃₂N₃O₇P 
• 868697-64-7 C₃₀H₂₇N₃O₅ 
• 868697-73-8 C₃₀H₂₈N₄O₅ 
• 868697-60-3 C₃₀H₂₁N₃O₄ 
• 868697-76-1 C₃₀H₂₁N₃O₄ 
• 868697-49-8 1(!-aminoethyl)-3-[4-(2-cyanophenoxy)anilino]-4-phenyl-2,5-dioxo-2,5-dihydro-1H-pyrrole 
• 868697-70-5 C₁₇H₁₀BrN₃O₃ 
• 868697-69-2 C₁₇H₁₁N₃O₃ 
• 868697-68-1 C₁₇H₁₃N₃O₃ 

Relevant academic research and scientific papers

Triazole sulfonate compound with bactericidal effect on bacteria causing rice disease

The invention relates to the field of rice plant disease control, specifically to a triazole sulfonate compound with a bactericidal effect on bacteria causing rice disease. The triazole sulfonate compound is not the compound as shown in the formula 1-6, t

Application of triazole sulfonate compound preventing and treating rice bacterial diseases

The invention relates to the field of preventing and treating rice plant diseases and in particular relates to application of triazole sulfonate compound preventing and treating rice bacterial diseases. The triazole sulfonate compound is one or more of co

Aggregation induced emission of excited-state intramolecular proton transfer compounds: Nanofabrication mediated white light emitting nanoparticles

Excited-state intramolecular proton transfer (ESIPT) compounds, 2-(2-((2-hydroxybenzylidine)amino)phenoxy)benzonitrile (1) and 2-(4-((2-hydroxy-4-methoxybenzylidine)amino)phenoxy)benzonitrile (2) exhibited aggregation induced enhanced emission (AIEE) in t

Discovery of 1,2,4-triazole-1,3-disulfonamides as dual inhibitors of mitochondrial complex II and complex III

Respiratory chain succinate-ubiquinone oxidoreductase (SQR or complex II) and ubihydroquinone-cytochrome (cyt) c oxidoreductase (cyt bc1 or complex III) have been demonstrated as the promising targets of numerous antibiotics and fungicides. As a continuation of our research work on the development of new fungicides, a series of 1,2,4-triazole-1,3-disulfonamide derivatives with dual functions targeting both SQR and cyt bc1 were designed and synthesized by coupling diverse diphenyl ether moieties with triazolesulfonamide units. These newly synthesized compounds were characterized by elemental analyses, 1H NMR and ESI-MS spectrometry. The in vitro assay indicated that most of the synthesized compounds displayed good inhibition against porcine succinate-cytochrome reductase (SCR) with IC50 values ranging from 3.2 to 81.8 μM, revealing much higher activity than that of the commercial control amisulbrom whose IC50 value is 93.0 μM. Further evaluation against the respective SQR and cyt bc1 indicated that most compounds exhibited SQR-inhibiting activity as well as cyt bc1-inhibiting activity, but the inhibition potency against SQR is much higher than that against cyt bc1, showing that the SCR inhibition might be contributed greatly by the SQR inhibition. The further antibacterial evaluation against Xanthomonas oryzae pv. oryzae revealed that four compounds showed excellent potency at the concentration of 20 μg mL-1. In particular, compounds 6h and 6j exhibited much better antibacterial activity than the commercial control bismerthiazol in terms of their EC50. Impressively, 6j has an EC90 of 33.62 μg mL-1, more than 10-fold higher than that of bismerthiazol.

3,4-DISUBSTITUTED MALEIMIDES FOR USE AS VASCULAR DAMAGING AGENTS

This invention relates to novel compounds of Formula (I) for use as vascular damaging agents: Formula (I) wherein Rl, R7, R8, R9, ARI, AR2, AR3, p, q and r are as described in the specification. The invention also relates to methods for preparing compounds of Formula (I), to their use as medicaments (including methods for the treatment of angiogenesis or disease states associated with angiogenesis) and to pharmaceutical compositions containing compounds of Formula (I).

Derivatives of quinoline as inhibitors for MEK

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof. wherein: n is 0-1; X and Y are independently selected from -NH-, -O-, -S-, or -NR8- where R8 is alkyl of 1-6 carbon atoms and X may additionally comprise a CH2 group; R7 is a group (CH2)mR9 where m is 0,or an integer of from 1-3 and R9 is a substituted aryl group, an optionally substituted cycloalkyl ring of up to 10 carbon atoms, or an optionally substituted heterocyclic ring or an N-oxide of any nitrogen containing ring; R6 is a divalent cycloalkyl of 3 to 7 carbon atoms, which may be optionally further substituted with one or more alkyl of 1 to 6 carbon atom groups; or is a divalent pyridinyl, pyimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally further substituted with one or more specified groups; R1, R2, R3 and R4 are each independently selected from hydrogen or various specified organic groups. Compounds are useful as pharmaceuticals for the inhibition of MEK activity.

Synthesis of diaryl ethers, diaryl thioethers, and diarylamines mediated by potassium fluoride-alumina and 18-crown-6: Expansion of scope and utility

An efficient alternative to the Ullmann ether synthesis of diaryl ethers, diaryl thioethers, and diarylamines involving the S(N)Ar addition of a phenol, thiophenol, or aniline to an appropriate aryl halide, mediated by potassium-fluoride alumina and 18-crown-6 in acetonitrile or DMSO, is described. Expansion of the reaction conditions to include DMSO as solvent has resulted in a far greater range of substitution patterns permitted on the electrophile. For example, it was found that electronically unfavorable 3- chlorobenzonitrile could be condensed with 3-methoxyphenol to form the corresponding diaryl ether in 66% yield, a combination not normally amenable to Ullmann coupling. Electron-withdrawing groups present on the electrophile may be as diverse as nitro, cyano, formyl, acetyl, ester, amide, and even aryl. The method features a simple reaction procedure that provides products in generally good to excellent purified yields.

Synthesis of Diaryl Ethers, Diaryl Thioethers, and Diarylamines Mediated by Potassium Fluoride-Alumina and 18-Crown-6

An efficient alternative to the copper-catalyzed synthesis (Ullmann ether synthesis) of diaryl ethers, diaryl thioethers, and diarylamines involving the potassium fluoride-alumina-mediated addition of a phenol, thiophenol, or an aniline to 2- or 4-fluorobenzonitriles catalyzed by 18-crown-6 is described.