148903-67-7

Upstream product

• 1363411-10-2 methyl 4-cyano-2-methylene-4-phenyl-4-(phenylamino)butanoate 
• 4553-59-7 2-anilino-2-phenylacetonitrile 
• 4686-14-0 2-phenyl-2-(phenylimino)acetonitrile 
• 538-51-2 benzylidene phenylamine 
• 98-86-2 acetophenone 
• 80-62-6 methacrylic acid methyl ester 
• 611-73-4 Benzoylformic acid 
• 100-52-7 benzaldehyde 
• 134993-85-4 ethyl 2-(benzenesulfonyl)acrylate 
• 4224-69-5 methyl 2-(bromomethyl)propenoate 
• 67-56-1 methanol 
• 15732-75-9 3-benzoyl-2-methylenepropionic acid 
• 71-43-2 benzene 
• 32323-74-3 2-(4-methyloxyphenylamino)-2-phenylacetonitrile 

Downstream Products

• 13300-09-9 4-methyl-6-phenylpyridazin-3(2H)-one 
• 36057-38-2 methyl (S)-2-methyl-4-oxo-4-phenylbutanoate 
• 36057-38-2 2-methyl-4-oxo-4-phenyl-butyric acid methyl ester 

Relevant academic research and scientific papers

Selective photoredox decarboxylation of α-ketoacids to allylic ketones and 1,4-dicarbonyl compounds dependent on cobaloxime catalysis

A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins.

Method for preparing allyl ketone compound through visible light and cobalt synergistic catalysis

The invention discloses a method for preparing an allyl ketone compound through visible light and cobalt synergistic catalysis. The method comprises the following steps: using alpha-carbonyl carboxylic acid and methacrylate olefin as reaction substrates; dissolving potassium tert-butoxide or 2, 6-dimethylpyridine serving as alkali, using 4-CzIPN as a visible-light-induced photocatalyst and using acobalt complex as a synergistic catalyst in a solvent to obtain a mixed solution, and irradiating the mixed solution with visible light under the protection of inert gas to obtain the allyl ketone compound. The reaction can be realized by visible light irradiation at room temperature, the method is simple and convenient to operate, the raw materials are easy to obtain, the whole reaction system is very green and environmentally friendly, reaction conditions are mild, the reaction can be completed under the action of a catalytic amount of the photocatalyst and the cobalt complex, equivalent additional oxidants are not needed, the reaction system is efficient and economical and is suitable for gram-level reaction on an amplified large scale and has huge potential large-scale application value.

Modular 1,1′-Ferrocenediyl-cored P-Stereogenic Diphosphines: ′′JDayPhos′′ Series and its Use in Rhodium(I)-Catalyzed Hydrogenation

A novel ferrocene-based P-stereogenic diphospine ligand series dubbed JDayPhos was developed, which rhodium(I) complexes of some of its members exhibited excellent enantioselectivity (up to >99% ee) and high activity in asymmetric hydrogenation of β-unsubstituted or -substituted itaconates and α-methylene-γ-oxo-carboxylates. (Figure presented.).

Eosin Y as a Direct Hydrogen-Atom Transfer Photocatalyst for the Functionalization of C?H Bonds

Eosin Y, a well-known economical alternative to metal catalysts in visible-light-driven single-electron transfer-based organic transformations, can behave as an effective direct hydrogen-atom transfer catalyst for C?H activation. Using the alkylation of C?H bonds with electron-deficient alkenes as a model study revealed an extremely broad substrate scope, enabling easy access to a variety of important synthons. This eosin Y-based photocatalytic hydrogen-atom transfer strategy is promising for diverse functionalization of a wide range of native C?H bonds in a green and sustainable manner.

Bromine-Radical-Mediated Synthesis of β-Functionalized β,γ- and δ,?-Unsaturated Ketones via C-H Functionalization of Aldehydes

The bromine-radical-mediated allylation reaction of aldehydes was studied. In the presence of V-65 as radical initiator, the reaction of aldehydes with allyl bromides gave β,γ-unsaturated ketones in good yields (13 examples, 45-84%). The reaction is trigg

Enzyme-Inspired Chiral Secondary-Phosphine-Oxide Ligand with Dual Noncovalent Interactions for Asymmetric Hydrogenation

Inspired by the unique character of enzymes, we developed novel chiral SPO (secondary-phosphine-oxide) ligand (SPO-Wudaphos) which can enter into both ion pair and H-bond noncovalent interactions. The novel chiral SPO-Wudaphos exhibited excellent results

Controllable regioselective construction of both functional α-methylene-β- and -γ-amino acid derivatives through an organocatalyzed tandem allylic alkylation and amination

A new controllable and regioselective allylic alkylation and amination reaction has been developed for the highly selective construction of compounds containing α-alkylidene-β-amino acid and α-methylene-γ- butyrolactam moieties. Furthermore, on the basis of this controllable strategy, multicomponent tandem reactions have also been accomplished. The subsequent transformations of the densely functionalized products have readily afforded a range of useful building blocks, which have potential utility in organic synthesis. Copyright

Construction of highly functional α-amino nitriles via a novel multicomponent tandem organocatalytic reaction: A facile access to α-methylene γ-lactams

The first tertiary amine-catalyzed multicomponent tandem Strecker-allylic-alkylation (SAA) reaction has been developed, which provides a facile access to functionalized α-amino nitriles, which could be readily converted into α-methylene-γ-butyrolactams. The Royal Society of Chemistry 2012.

Construction of highly functional quaternary carbon stereocenters via an organocatalytic tandem cyanation-allylic alkylation reaction

The first tertiary amine-catalyzed tandem cyanation-allyic alkylation (CAA) reaction of aldehydes, appropriate cyanide sources, and Morita-Baylis-Hillman (MBH) adducts has been developed, which provides a facile access to densely functionalized products c

Synthesis and hypotensive activity of some 6-(substituted aryl)-4-methyl-2,3-dihydropyridazin-3-ones

6-(Substituted aryl)-4-methyl-2,3-dihydropyridazin-3-ones are synthesized by cyclisation of appropriate β-(substituted aroyl)-2-methylene propionate with hydrazine hydrate in the presence of sodium acetate. The title compounds are tested for hypotensive activity, non-invasively, by tail-cuff method and are found to possess significant hypotensive activity in normotensive rats.