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Cyano(phenyl)methyl ethyl carbonate, also known as ethyl 2-cyanobenzylate, is an organic compound with the chemical formula C10H9NO2. It is a colorless liquid that is soluble in organic solvents and has a molecular weight of 175.19 g/mol. cyano(phenyl)methyl ethyl carbonate is characterized by the presence of a cyano group (-CN) attached to a phenyl ring, which is further connected to an ethyl carbonate group (-OOCCH2CH3). It is synthesized through the reaction of ethyl chloroformate with 2-cyanobenzyl alcohol and is used as an intermediate in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. Due to its reactivity, it is important to handle cyano(phenyl)methyl ethyl carbonate with care, following proper safety protocols.

6443-66-9

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6443-66-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6443-66-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,4 and 3 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6443-66:
(6*6)+(5*4)+(4*4)+(3*3)+(2*6)+(1*6)=99
99 % 10 = 9
So 6443-66-9 is a valid CAS Registry Number.

6443-66-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name [cyano(phenyl)methyl] ethyl carbonate

1.2 Other means of identification

Product number -
Other names 2-ethoxycarbonyloxy-(S)-2-phenyl-acetonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6443-66-9 SDS

6443-66-9Relevant academic research and scientific papers

Catalytic asymmetric cyanoethoxycarbonylation of aldehydes using self-assembled titanium catalysts

Wang, Wentao,Gou, Shaohua,Liu, Xiaohua,Feng, Xiaoming

, p. 2875 - 2878 (2007)

A new self-assembled titanium catalyst system has been developed for the asymmetric cyanoethoxycarbonylation of aldehydes which produced the desired products in moderate to excellent yields (up to 99%) with high enantioselectivities (up to 94% ee) under m

Asymmetric cyanoethoxycarbonylation of aldehydes catalyzed by heterobimetallic aluminum lithium bis(binaphthoxide) and cinchonine

Gou, Shaohua,Wang, Jun,Liu, Xiaohua,Wang, Wentao,Chen, Fu-Xue,Feng, Xiaoming

, p. 343 - 349 (2007)

Highly efficient catalytic asymmetric cyanoethoxycarbonylation of aldehydes was achieved by 10 mol% cinchonine with 10 mol% heterometallic (S)-aluminum lithium bis(binaphthoxide), which gave the cyanohydrins ethyl carbonates in excellent isolated yields (

Catalytic, Asymmetric Synthesis of Cyanohydrin Ethyl Carbonates

Belokon, Yuri N.,Blacker, A. John,Clutterbuck, Lisa A.,North, Michael

, p. 4505 - 4507 (2003)

(Equation presented) The bimetallic titanium complex [(salen)TiO] 2, where salen is the ligand derived from (R,R)-cyclohexanediamine and 3,5-di-tert-butyl-salicylaldehyde, has been shown to catalyze the asymmetric addition of ethyl cyanoformate

Tuning the Catalytic Activity of Tertiary-Amine Functionalized Polyacrylonitrile Fibers by Adjusting the Surface Microenvironment

Li, Pengyu,Liu, Yuanyuan,Cao, Jian,Tao, Minli,Zhang, Wenqin

, p. 3725 - 3732 (2017)

Polyacrylonitrile fibers were functionalized with different amines to construct special tridimensional catalytic microenvironments at the surface. The polarity of the microenvironments at the surface of the fiber catalyst was tuned by changing the ratio o

Highly enantioselective cyanation of aldehydes catalyzed by a multicomponent titanium complex

Gou, Shaohua,Chen, Xiaohong,Xiong, Yan,Feng, Xiaoming

, p. 5732 - 5736 (2006)

A new multicomponent bifunctional catalytic system based on a titanium complex was used for the efficient enantioselective cyanation of aldehydes. The catalyst was readily prepared from tetraisopropyl titanate (Ti(Oi-Pr) 4), (S)-6,6′-dibromo-1,

Highly enantioselective cyanoformylation of aldehydes catalyzed by a mononuclear salen-Ti(OiPr)4 complex produced in situ

Chen, Shi-Kui,Peng, Dan,Zhou, Hui,Wang, Li-Wei,Chen, Fu-Xue,Feng, Xiao-Ming

, p. 639 - 644 (2007)

An efficient enantioselective cyanoformylation of aldehydes with ethyl cyanoformate, catalyzed by a salen-Ti(OiPr)4 complex generated in situ, has been developed. Studies of non-linear effects indicated that the mononuclear salen-titanium compl

Kinetics and mechanism of base catalysed ethyl cyanoformate addition to aldehydes Dedicated to the memory of Professor Sandy McKillop

North, Michael,Urwin, Stephanie

, p. 7100 - 7105 (2014)

The mechanism by which tertiary amines catalyse the formation of cyanohydrin carbonates from aldehydes and alkyl cyanoformates is investigated by means of a kinetic study. The reaction rate shows a second order dependence on amine concentration unless the

Asymmetric cyano-ethoxycarbonylation of aldehydes catalyzed by self-assembled titanium catalyst

Gou, Shaohua,Liu, Xiaohua,Zhou, Xin,Feng, Xiaoming

, p. 7935 - 7941 (2007)

A new self-assembled catalyst based on titanium complex has been developed for the effective enantioselective cyano-ethoxycarbonylation of aldehydes. The self-assembled catalyst was readily prepared from (R)-3,3′-bis((methyl((S)-1-phenylethyl)amino)methyl

Consecutive reactions to construct tricarbonyl compounds and synthetic applications thereof

Madro?ero, Diego,Mujica-Martinez, Cesar A.,Vázquez, Alfredo

, p. 33235 - 33244 (2021/12/09)

Lithium anions derived from O-carbonate-protected cyanohydrins undergo conjugate addition to cycloalkenones with the concomitant transfer of the alkoxycarbonyl group to produce tricarbonyl compounds. These products offer numerous possibilities for further

Efficient synthesis in water of mixed carbonates of cyanohydrins from aromatic aldehydes

Héctor Manuel, Torres Domínguez,Luis ángel, Maldonado,Ronan, Le Lagadec

supporting information, (2019/12/11)

An efficient preparation of cyanohydrin ethyl carbonates via cyanocarbonation of aromatic and hetero-aromatic aldehydes with sodium cyanide and ethyl chlorocarbonate using commercial surfactants (5 mol %) in aqueous media at low temperature afforded almos

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