6443-66-9Relevant articles and documents
Catalytic asymmetric cyanoethoxycarbonylation of aldehydes using self-assembled titanium catalysts
Wang, Wentao,Gou, Shaohua,Liu, Xiaohua,Feng, Xiaoming
, p. 2875 - 2878 (2007)
A new self-assembled titanium catalyst system has been developed for the asymmetric cyanoethoxycarbonylation of aldehydes which produced the desired products in moderate to excellent yields (up to 99%) with high enantioselectivities (up to 94% ee) under m
Catalytic, Asymmetric Synthesis of Cyanohydrin Ethyl Carbonates
Belokon, Yuri N.,Blacker, A. John,Clutterbuck, Lisa A.,North, Michael
, p. 4505 - 4507 (2003)
(Equation presented) The bimetallic titanium complex [(salen)TiO] 2, where salen is the ligand derived from (R,R)-cyclohexanediamine and 3,5-di-tert-butyl-salicylaldehyde, has been shown to catalyze the asymmetric addition of ethyl cyanoformate
Highly enantioselective cyanation of aldehydes catalyzed by a multicomponent titanium complex
Gou, Shaohua,Chen, Xiaohong,Xiong, Yan,Feng, Xiaoming
, p. 5732 - 5736 (2006)
A new multicomponent bifunctional catalytic system based on a titanium complex was used for the efficient enantioselective cyanation of aldehydes. The catalyst was readily prepared from tetraisopropyl titanate (Ti(Oi-Pr) 4), (S)-6,6′-dibromo-1,
Kinetics and mechanism of base catalysed ethyl cyanoformate addition to aldehydes Dedicated to the memory of Professor Sandy McKillop
North, Michael,Urwin, Stephanie
, p. 7100 - 7105 (2014)
The mechanism by which tertiary amines catalyse the formation of cyanohydrin carbonates from aldehydes and alkyl cyanoformates is investigated by means of a kinetic study. The reaction rate shows a second order dependence on amine concentration unless the
Consecutive reactions to construct tricarbonyl compounds and synthetic applications thereof
Madro?ero, Diego,Mujica-Martinez, Cesar A.,Vázquez, Alfredo
, p. 33235 - 33244 (2021/12/09)
Lithium anions derived from O-carbonate-protected cyanohydrins undergo conjugate addition to cycloalkenones with the concomitant transfer of the alkoxycarbonyl group to produce tricarbonyl compounds. These products offer numerous possibilities for further
Asymmetric Carboxycyanation of Aldehydes by Cooperative AlF/Onium Salt Catalysts: from Cyanoformate to KCN as Cyanide Source
Brodbeck, Daniel,álvarez-Barcia, Sonia,Meisner, Jan,Broghammer, Florian,Klepp, Julian,Garnier, Delphine,Frey, Wolfgang,K?stner, Johannes,Peters, René
supporting information, p. 1515 - 1524 (2019/01/09)
Asymmetric 1,2-additions of cyanide yield enantioenriched cyanohydrins as versatile chiral building blocks. Next to HCN, volatile organic cyanide sources are usually used. Among them, cyanoformates are more attractive on technical scale than TMSCN for cos