32323-74-3

Upstream product

• 151-50-8 potassium cyanide 
• 20265-97-8 p-anisidine hydrochloride 
• 100-52-7 benzaldehyde 
• 143-33-9 sodium cyanide 
• 104-94-9 4-methoxy-aniline 
• 7677-24-9 trimethylsilyl cyanide 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 623-49-4 ethyl cyanoformate 
• 4746-48-9 2-hydroxy-2,2-diphenylacetonitrile 
• 17377-95-6 benzyl(4-methoxyphenyl)amine 
• 532-28-5 (RS)-mandelonitrile 
• 2700-22-3 Benzylidenemalononitrile 
• 100-42-5 styrene 
• 6554-98-9 trans-4-Hydroxystilbene 

Downstream Products

• 60561-74-2 N-(p-methoxy)phenyl phenylglycine 
• 1256842-39-3 ethyl 3-cyano-3-(4-methoxyphenylamino)-3-phenylpropanoate 
• 1608491-07-1 tert-butyl 2-(cyanomethyl)-4-oxo-4-phenylbutanoate 
• 1608491-30-0 methyl 1-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-3-carboxylate 
• 1404296-24-7 methyl 4-cyano-4-{[2-(methoxycarbonyl)allyl](4-methoxyphenyl)amino}-2-methylene-4-phenylbutanoate 
• 1363411-28-2 1-(4-methoxyphenyl)-4-methylene-5-oxo-2-phenylpyrrolidine-2-carbonitrile 
• 1363411-16-8 methyl 4-cyano-4-(4-methoxyphenylamino)-2-methylene-4-phenylbutanoate 
• 1363411-36-2 C₁₂H₁₀N₂O 
• 1404296-23-6 methyl 5-cyano-1-(4-methoxyphenyl)-5-phenylpyrrolidine-3-carboxylate 
• 1404296-22-5 1-(4-methoxyphenyl)-4-methyl-5-oxo-2-phenyl-2,5-dihydro-1H-pyrrole-2-carbonitrile 
• 148903-67-7 β-benzoyl-2-methylenepropionic acid methyl ester 
• 1404296-07-6 methyl 4-cyano-4-(4-methoxyphenylamino)-2-methylene-3,4-diphenylbutanoate 
• 1404296-06-5 methyl 2-({[cyano(phenyl)methyl](4-methoxyphenyl)amino}(phenyl)methyl)acrylate 
• 72867-56-2 C₂₂H₁₉N₂O₂⁽¹⁺⁾*BF₄^(1-) 

Relevant academic research and scientific papers

A carbon dioxide-promoted three-component Strecker reaction

A three-component Strecker reaction of aldehydes, amines and KCN has been performed for the first time in supercritical carbon dioxide. In the proposed procedure, non-toxic and non-flammable carbon dioxide acts not only as an environmentally benign reaction medium but also as a reaction promoter via in situ formation of carbonic acid which provides a gradual release of the true cyanating agent (HCN) from available KCN. The reaction conditions (pressure, temperature, and concentrations of reagents) were optimized, and various aromatic and aliphatic amines and aldehydes were transformed into valuable α-amino nitriles including prospective pharmacological substances. The equimolar amount of used cyanogen reagent, carrying out the process in a sealed autoclave in a 'green' solvent medium under mild conditions (90 bar, 35 °C) along with the high yields of products and the scalability of the developed procedure make it suitable for sustainable industrial applications. This journal is

Cyano-borrowing: Titanium-catalyzed direct amination of cyanohydrins with amines and enantioselective examples

The direct amination of cyanohydrins with amines via a catalytic cyano-borrowing reaction was developed. The transformation features broad substrate scope, excellent functional group compatibility, and very mild and simple operations. Moreover, a titanium

Radical Rearrangement of Aryl/Alkylidene Malononitriles via Aza Michael Addition/Decynoformylation/Addition Sequence: An Access to α-Aminonitriles and α-Aminoamides

An efficient, safe, and environmentally friendly tertiary butyl hydrogen peroxide (TBHP)-mediated rearrangement of aryl/alkylidene malononitrile with anilines has been developed with in situ generation of HCN as the cyanide source for the synthesis of sub

Role of aromatic: Vs. aliphatic amine for the variation of structural, electrical and catalytic behaviors in a series of silver phosphonate extended hybrid solids

Four inorganic-organic hybrid silver phosphonate compounds, [Ag(C10H8N2)(H4hedp)] (1), [Ag2(C10H8N2)(H3hedp)]·2H2O (2), [C4H12N2][Ag4(H2hedp)2] (3) and [C4H12N2][Ag10(H2hedp)4(H2O)2]·2H2O (4) (H5hedp = 1-hydroxyethane-1,1-diphosphonic acid), have been pre

Iron-Catalyzed Nitrene Transfer Reaction of 4-Hydroxystilbenes with Aryl Azides: Synthesis of Imines via C=C Bond Cleavage

C=C bond breaking to access the C=N bond remains an underdeveloped area. A new protocol for C=C bond cleavage of alkenes under nonoxidative conditions to produce imines via an iron-catalyzed nitrene transfer reaction of 4-hydroxystilbenes with aryl azides is reported. The success of various sequential one-pot reactions reveals that the good compatibility of this method makes it very attractive for synthetic applications. On the basis of experimental observations, a plausible reaction mechanism is also proposed.

Strecker reactions with hexacyanoferrates as non-toxic cyanide sources

The Strecker reaction is the most widely applied three-component reaction. Although highly useful for the preparation of α-amino nitriles, α-amino acids, hydantoins and numerous related compounds, the need for the application of toxic sources of HCN limits its application in both academic and industrial settings. Here, we present a facile protocol for Strecker reactions using a mixture of potassium ferri- and ferrocyanides as a non-toxic substitute.

Borane-Catalyzed Chemoselectivity-Controllable N-Alkylation and ortho C-Alkylation of Unprotected Arylamines Using Benzylic Alcohols

An unprecedented protocol for the efficient and highly chemoselective alkylation of unprotected arylamines using alcohols catalyzed by B(C6F5)3 has been developed. The reaction gives N-alkylated products and ortho C-alkylated products in different solvents in good chemoselectivities and yields. Control experiments and DFT calculations indicated that the borane underwent alcohol/arylamine exchange to ensure catalytic activity, and a possible mechanism involving a carbocation is proposed.

A unique combination of KI/ZnFe2O4 as a catalyst for oxidative Strecker reaction

α-Aminonitriles as key intermediates for the preparation of α-amino acid derivatives, amides, diamines, peptides, proteins and heterocycles were synthesized through methylarene oxidation in the Strecker reaction using a unique combination of KI/ZnFe2O4 as the best catalyst and aqueous tert-butyl hydroperoxide as oxidant. A wide range of amines and methylarenes were converted to the corresponding products. Operational simplicity, short reaction time and recyclability of the catalyst are advantages of this protocol.

A N - aryl methylaniline of α - carbonitriding method

A N - aryl methylaniline of α - carbonitriding method. This law to various N - aryl aniline derivatives as raw materials, trimethylsilyl cyanide as the cyanide reagent, 2, 3 - dichloro - 5, 6 - dicyano - 1, 4 - benzoquinone as oxidizing agent in a solvent reaction after concentration, purification of a simple process to get the finished product. The purpose is for the existing N - aryl aniline oxidation carbonitriding method of deficiencies, provide a new synthesis method. The method adopts the low price, low toxicity, and easily obtained 2, 3 - dichloro - 5, 6 - dicyano - 1, 4 - benzoquinone as the oxidizing agent, the non-metal ion catalysis, high-efficiently the various N - aryl methylaniline with three oxidation of trimethylsilyl cyanide. The method of the invention the process is simple, preparing the reaction production safety, easy operation, reaction time is short, favorable to the industrialized.

Cross-dehydrogenative coupling strategy for phosphonation and cyanation of secondary N-alkyl anilines by employing 2,3-dichloro-5,6-dicyanobenzoquinone

The cross-dehydrogenative coupling strategy for metal-free phosphonation and cyanation of secondary N-alkyl anilines has been developed firstly under mild reaction conditions. Based on detailed optimization of reaction conditions, the substrate generality of N-alkyl anilines and various hydrogen phosphonates has been investigated, and a series of versatile α-aminophosphonates and α-aminonitriles were therefore furnished in good to excellent yields. A plausible collective reaction mechanism through dehydrogenation to imine formation, then to respective α-aminophosphonates and α-aminonitriles was proposed.