32323-74-3

Upstream product

• 151-50-8 potassium cyanide 
• 20265-97-8 p-anisidine hydrochloride 
• 100-52-7 benzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 1613-90-7 4-methoxy-N-[(E)-phenylmethylidene]aniline 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 104-94-9 4-methoxy-aniline 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 623-49-4 ethyl cyanoformate 
• 557-21-1 zinc(II) cyanide 
• 17377-95-6 benzyl(4-methoxyphenyl)amine 
• 100-51-6 benzyl alcohol 
• 143-33-9 sodium cyanide 
• 532-28-5 (RS)-mandelonitrile 

Downstream Products

• 78139-32-9 2-(4-methoxyphenylamino)-2-phenylacetamide 
• 72867-36-8 (N-benzoyl-p-anisidino)-phenyl-acetonitrile 
• 72867-60-8 dimethyl 1-(4-methoxyphenyl)-2,5-diphenyl-1H-pyrrole-3,4-dicarboxylate 
• 72867-56-2 C₂₂H₁₉N₂O₂⁽¹⁺⁾*BF₄^(1-) 
• 1256842-39-3 ethyl 3-cyano-3-(4-methoxyphenylamino)-3-phenylpropanoate 
• 1608491-30-0 methyl 1-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-3-carboxylate 
• 1608491-07-1 tert-butyl 2-(cyanomethyl)-4-oxo-4-phenylbutanoate 
• 1404296-24-7 methyl 4-cyano-4-{[2-(methoxycarbonyl)allyl](4-methoxyphenyl)amino}-2-methylene-4-phenylbutanoate 
• 1363411-28-2 1-(4-methoxyphenyl)-4-methylene-5-oxo-2-phenylpyrrolidine-2-carbonitrile 
• 1363411-16-8 methyl 4-cyano-4-(4-methoxyphenylamino)-2-methylene-4-phenylbutanoate 
• 1363411-36-2 C₁₂H₁₀N₂O 
• 1404296-23-6 methyl 5-cyano-1-(4-methoxyphenyl)-5-phenylpyrrolidine-3-carboxylate 
• 1404296-22-5 1-(4-methoxyphenyl)-4-methyl-5-oxo-2-phenyl-2,5-dihydro-1H-pyrrole-2-carbonitrile 
• 148903-67-7 β-benzoyl-2-methylenepropionic acid methyl ester 

Relevant academic research and scientific papers

A carbon dioxide-promoted three-component Strecker reaction

A three-component Strecker reaction of aldehydes, amines and KCN has been performed for the first time in supercritical carbon dioxide. In the proposed procedure, non-toxic and non-flammable carbon dioxide acts not only as an environmentally benign reaction medium but also as a reaction promoter via in situ formation of carbonic acid which provides a gradual release of the true cyanating agent (HCN) from available KCN. The reaction conditions (pressure, temperature, and concentrations of reagents) were optimized, and various aromatic and aliphatic amines and aldehydes were transformed into valuable α-amino nitriles including prospective pharmacological substances. The equimolar amount of used cyanogen reagent, carrying out the process in a sealed autoclave in a 'green' solvent medium under mild conditions (90 bar, 35 °C) along with the high yields of products and the scalability of the developed procedure make it suitable for sustainable industrial applications. This journal is

Role of aromatic: Vs. aliphatic amine for the variation of structural, electrical and catalytic behaviors in a series of silver phosphonate extended hybrid solids

Four inorganic-organic hybrid silver phosphonate compounds, [Ag(C10H8N2)(H4hedp)] (1), [Ag2(C10H8N2)(H3hedp)]·2H2O (2), [C4H12N2][Ag4(H2hedp)2] (3) and [C4H12N2][Ag10(H2hedp)4(H2O)2]·2H2O (4) (H5hedp = 1-hydroxyethane-1,1-diphosphonic acid), have been pre

Cyano-borrowing: Titanium-catalyzed direct amination of cyanohydrins with amines and enantioselective examples

The direct amination of cyanohydrins with amines via a catalytic cyano-borrowing reaction was developed. The transformation features broad substrate scope, excellent functional group compatibility, and very mild and simple operations. Moreover, a titanium

Radical Rearrangement of Aryl/Alkylidene Malononitriles via Aza Michael Addition/Decynoformylation/Addition Sequence: An Access to α-Aminonitriles and α-Aminoamides

An efficient, safe, and environmentally friendly tertiary butyl hydrogen peroxide (TBHP)-mediated rearrangement of aryl/alkylidene malononitrile with anilines has been developed with in situ generation of HCN as the cyanide source for the synthesis of sub

Iron-Catalyzed Nitrene Transfer Reaction of 4-Hydroxystilbenes with Aryl Azides: Synthesis of Imines via C=C Bond Cleavage

C=C bond breaking to access the C=N bond remains an underdeveloped area. A new protocol for C=C bond cleavage of alkenes under nonoxidative conditions to produce imines via an iron-catalyzed nitrene transfer reaction of 4-hydroxystilbenes with aryl azides is reported. The success of various sequential one-pot reactions reveals that the good compatibility of this method makes it very attractive for synthetic applications. On the basis of experimental observations, a plausible reaction mechanism is also proposed.

Strecker reactions with hexacyanoferrates as non-toxic cyanide sources

The Strecker reaction is the most widely applied three-component reaction. Although highly useful for the preparation of α-amino nitriles, α-amino acids, hydantoins and numerous related compounds, the need for the application of toxic sources of HCN limits its application in both academic and industrial settings. Here, we present a facile protocol for Strecker reactions using a mixture of potassium ferri- and ferrocyanides as a non-toxic substitute.

Borane-Catalyzed Chemoselectivity-Controllable N-Alkylation and ortho C-Alkylation of Unprotected Arylamines Using Benzylic Alcohols

An unprecedented protocol for the efficient and highly chemoselective alkylation of unprotected arylamines using alcohols catalyzed by B(C6F5)3 has been developed. The reaction gives N-alkylated products and ortho C-alkylated products in different solvents in good chemoselectivities and yields. Control experiments and DFT calculations indicated that the borane underwent alcohol/arylamine exchange to ensure catalytic activity, and a possible mechanism involving a carbocation is proposed.

A unique combination of KI/ZnFe2O4 as a catalyst for oxidative Strecker reaction

α-Aminonitriles as key intermediates for the preparation of α-amino acid derivatives, amides, diamines, peptides, proteins and heterocycles were synthesized through methylarene oxidation in the Strecker reaction using a unique combination of KI/ZnFe2O4 as the best catalyst and aqueous tert-butyl hydroperoxide as oxidant. A wide range of amines and methylarenes were converted to the corresponding products. Operational simplicity, short reaction time and recyclability of the catalyst are advantages of this protocol.

A N - aryl methylaniline of α - carbonitriding method

A N - aryl methylaniline of α - carbonitriding method. This law to various N - aryl aniline derivatives as raw materials, trimethylsilyl cyanide as the cyanide reagent, 2, 3 - dichloro - 5, 6 - dicyano - 1, 4 - benzoquinone as oxidizing agent in a solvent reaction after concentration, purification of a simple process to get the finished product. The purpose is for the existing N - aryl aniline oxidation carbonitriding method of deficiencies, provide a new synthesis method. The method adopts the low price, low toxicity, and easily obtained 2, 3 - dichloro - 5, 6 - dicyano - 1, 4 - benzoquinone as the oxidizing agent, the non-metal ion catalysis, high-efficiently the various N - aryl methylaniline with three oxidation of trimethylsilyl cyanide. The method of the invention the process is simple, preparing the reaction production safety, easy operation, reaction time is short, favorable to the industrialized.

Copper-vitamin B6 coated on maghemite nanoparticles: A new convenient dual catalysis system to synthesize α-aminonitriles from benzyl alcohols

A novel and effective dual catalysis system, copper combined with pyridoxal phosphate, which is anchored in maghemite nanoparticles were designed and applied to synthesize α-aminonitriles from benzyl alcohols. This catalytic system has the potential ability to perform oxidation reactions and subsequently synthesize alpha-amino nitrile in a reaction environment. Thus, the purpose of this paper is introducing a heterogeneous, sustainable and recyclable catalytic system to perform reactions that require a transition metal catalyst and organocatalyst continuously to achieve a target molecule. The catalysis system is examined and investigated with seven useful analyses such as FT-IR, TGA, VSM, SEM, TEM, XRD, and ICP.