148905-78-6

Basic information

• Product Name: Bexlosteride.
• Synonyms: Benzo[f]quinolin-3(2H)-one,8-chloro-1,4,4a,5,6,10b-hexahydro-4-methyl-, (4aR-trans)-; Bexlosteride; LY300502
• CAS NO: 148905-78-6
• Molecular Formula: C14H16ClNO
• Molecular Weight: 249.73594
• Mol File: 148905-78-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 413.9°Cat760mmHg
• Flash Point: 204.1°C
• Appearance: /
• Density: 1.202g/cm³
• Vapor Pressure: 4.65E-07mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: Bexlosteride.(CAS DataBase Reference)
• NIST Chemistry Reference: Bexlosteride.(148905-78-6)
• EPA Substance Registry System: Bexlosteride.(148905-78-6)

Safety Data

• Hazardous Substances Data: 148905-78-6(Hazardous Substances Data)

Usage

Uses

Treatment of prostate cancer (inhibits human type I isoform of 5 - reductase).

InChI:InChI=1/C14H16ClNO/c1-16-13-6-2-9-8-10(15)3-4-11(9)12(13)5-7-14(16)17/h3-4,8,12-13H,2,5-7H2,1H3/t12-,13-/m1/s1

Upstream product

• 74-87-3 methylene chloride 
• 205105-67-5 trans-dl-8-chloro-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 152237-49-5 cis-dl-8-bromo-4-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 
• 4755-72-0 Chloro-phenyl-acetic acid 
• 1878-66-6 4-chlorophenylacetic Acid 
• 148905-81-1 (-)-(4AR)-(10BR)-8-chloro-4-(S-α-methylbenzyl)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 
• 148835-22-7 8-Chloro-4-((S)-1-phenyl-ethyl)-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-one 
• 148835-23-8 (6-Chloro-3,4-dihydro-naphthalen-2-yl)-((S)-1-phenyl-ethyl)-amine 
• 17556-18-2 6-chloro-3,4-dihydro-1H-naphthalen-2-one 
• 161320-13-4 methyl 3-<(2-R-N-tert-butyloxycarbonylmethylamino-6-chloro-S-1,2,3,4-tetrahydronaphthalen)-1-yl>propionate 
• 152323-03-0 trans-dl-8-chloro-4-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 
• 161320-16-7 ethyl 3-<(2-R-N-tert-butyloxycarbonylmethylamino-6-chloro-S-1,2,3,4-tetrahydronaphtalen)-1-yl>-propionate 
• 148905-77-5 (+)-(4AR)-(10BR)-8-chloro-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 

Relevant articles and documents

Method of preventing prostatic cancer development

A series of benzoquinolin-3-ones are pharmaceuticals effective in preventing the development of prostatic cancer, or preventing or treating the metastasis to bone of prostatic cancer.

Methods for inhibiting bone loss

The present invention provides methods of inhibiting bone loss in mammals via the administration to a mammal in need of such treatment an effective amount of a compound from a series of benzoquinolin-3-ones. Such compounds also are sequentially or concurrently coadministered with a bone antiresorptive agent or a bone anabolic agent.

Benzo (f) quinolinones as 5-alpha-reductase inhibitors

This invention relates to hexa- and octahydrobenzo[f]quinolin-3-ones, pharmaceutical formulations containing those compounds and methods of their use as steroid 5α reductase inhibitors.