148963-13-7Relevant academic research and scientific papers
Efficient palladium-catalyzed amination of aryl chlorides using dicyclo-hexylamino[(2,6-dimethyl)morpholino]phenylphosphine as a PN2 ligand
Park, Song-Eun,Kang, Seung Beom,Jung, Kwang-Ju,Won, Ju-Eun,Lee, Sang-Gyeong,Yoon, Yong-Jin
, p. 815 - 823 (2009)
The palladium-catalyzed amination of aryl chlorides with various amines is accomplished using dicyclohexyl- amino[(2,6-dimethyl)morpholino]phenylphosphine as a bulky electron-rich monoaryl phosphine ligand. The optimized reaction conditions required the use of 1 mol% each of catalyst and ligand. Georg Thieme Verlag Stuttgart.
Syngas Instead of Hydrogen Gas as a Reducing Agent─A Strategy To Improve the Selectivity and Efficiency of Organometallic Catalysts
Afanasyev, Oleg I.,Chusov, Denis,Ostrovskii, Vladimir S.,Podyacheva, Evgeniya
, p. 5145 - 5154 (2022/05/02)
Catalytic reduction reactions play a major role in modern chemistry and are often based on hydrogen gas as a reducing agent. However, the high reactivity of hydrogen is often accompanied by low selectivity on the simple catalysts. Herein, we showed that the usage of syngas as a reducing agent can be a more efficient and selective strategy. Based on control experiments, a plausible mechanism was proposed to explain the superior performance of syngas. The versatility of this approach was demonstrated by successful application to three reactions using different metal catalysts: direct reductive amination, reductive esterification, and the tandem CH-reductive alkylation-hydrolysis-decarboxylation. Catalyst turnover numbers up to 30,000 were achieved. Moreover, the developed strategy showed improved selectivity and functional group compatibility as compared to the use of hydrogen gas.
A simple and convenient method for the synthesis of N, N-diaryl tertiary amines
Wekesa, Francis S.,Phadke, Neha,Jahier, Claire,Cordes, David B.,Findlater, Michael
, p. 1046 - 1051 (2014/05/06)
Direct preparation of tertiary amines in which two substituents are aromatic is described. In the presence of either the inorganic base sodium tert-butoxide or the sterically hindered organic base diisopropylethylamine, the alkylation of secondary diarylamines is achieved smoothly. In contrast to methods previously reported in the literature, this procedure is high-yielding and does not require the use of transition-metal catalysts or functional-group-intolerant hydride reductants. Georg Thieme Verlag Stuttgart ? New York.
