149021-01-2

Basic information

• Product Name: (Trimethylsilyldifluoromethyl)benzene
• Synonyms: (Trimethylsilyldifluoromethyl)benzene
• CAS NO: 149021-01-2
• Molecular Formula: C₁₀H₁₄F₂Si
• Molecular Weight: 200.3004664
• Mol File: 149021-01-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (Trimethylsilyldifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (Trimethylsilyldifluoromethyl)benzene(149021-01-2)
• EPA Substance Registry System: (Trimethylsilyldifluoromethyl)benzene(149021-01-2)

Safety Data

• Hazardous Substances Data: 149021-01-2(Hazardous Substances Data)

Usage

General Description

(Trimethylsilyldifluoromethyl)benzene is a chemical compound with the formula C10H14F2Si. It is a colorless liquid at room temperature, and is used as a building block in organic synthesis. It is commonly used as a reagent in the production of pharmaceuticals and agrochemicals, as well as in the manufacture of electronic materials. (Trimethylsilyldifluoromethyl)benzene is known for its ability to introduce difluoromethyl groups into organic molecules, making it a valuable tool in the development of new materials and drugs. It is important to handle this compound with care, as it is volatile and can be hazardous if not used properly.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 98-08-8 α,α,α-trifluorotoluene 
• 98-15-7 3-chlorotrifluoromethylbenzene 
• 98-56-6 4-chlorobenzotrifluoride 
• 349-50-8 (chlorodifluoromethyl)benzene 

Downstream Products

• 196080-79-2 methylbenzene 
• 14595-76-7 α,α.α-tris(trimethylsilyl)toluene 
• 22235-32-1 [(difluorophenylmethyl)sulfanyl]benzene 
• 339-30-0 2,2-difluoro-N-2-diphenylacetamide 
• 1494-20-8 2,2-difluoro-1,2-diphenylethan-1-ol 

Relevant articles and documents

Selective electrochemical synthesis and reactivity of functional benzylic fluorosilylsynthons

Electrochemical reductive silylation of meta-(trifluoromethyl)arenes by the sacrificial anode technique selectively led to meta-trimethylsilyldifluoromethylarenes (ArCF2TMS), in the presence of an excess of TMSCl and in a THF/cosolvent mixture

Cu-deposits on Mg metal surfaces promote electron transfer reactions

The enhancement of the electron transfer processes in the Grignard reagent formation-type ring silylation and the defluorination-silylation of perfluoroalkyl benzenes by Cu(0)-deposited Mg metal were confirmed. Microscopic analysis and substituent effects implied a different reduction process in the presence of Cu-deposited Mg metal than in the presence of bare Mg metal.

Selective electrosynthesis of (trimethylsilyldifluoro)methylbenzene, a PhCF2-precursor; conditions for a molar scale preparation without HMPA

Electrochemical reductive silylation of trifluoromethylbenzene by the sacrificial anode technique selectively led, in a THF/DMPU mixture instead of THF/HMPA and according to the charge passed, to the corresponding mono-, bis- or tris-trimethylsilyl derivatives, respectively PhCF2TMS, PhCF(TMS)2 and PhC(TMS)3. This reaction, without any chemical equivalent, was extended to a molar scale synthesis, using a tubular flow cell.