149021-01-2

Basic information

• Product Name: (Trimethylsilyldifluoromethyl)benzene
• Synonyms: (Trimethylsilyldifluoromethyl)benzene
• CAS NO: 149021-01-2
• Molecular Formula: C₁₀H₁₄F₂Si
• Molecular Weight: 200.3004664
• Mol File: 149021-01-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (Trimethylsilyldifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (Trimethylsilyldifluoromethyl)benzene(149021-01-2)
• EPA Substance Registry System: (Trimethylsilyldifluoromethyl)benzene(149021-01-2)

Safety Data

• Hazardous Substances Data: 149021-01-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(Trimethylsilyldifluoromethyl)benzene is used as a reagent for the production of various pharmaceuticals. Its ability to introduce difluoromethyl groups into organic molecules aids in the synthesis of new drugs, potentially enhancing their efficacy and properties.
Used in Agrochemical Industry:
In the agrochemical industry, (Trimethylsilyldifluoromethyl)benzene serves as a reagent in the manufacturing process of various agrochemicals. Its role in introducing difluoromethyl groups can lead to the development of more effective and targeted agrochemical products.
Used in Electronic Materials Manufacturing:
(Trimethylsilyldifluoromethyl)benzene is also utilized in the production of electronic materials. Its unique properties contribute to the creation of advanced materials with specific characteristics required for various applications in the electronics sector.
Safety Note:
It is crucial to handle (Trimethylsilyldifluoromethyl)benzene with care due to its volatile nature. Proper safety measures should be taken to prevent potential hazards associated with its use.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 98-08-8 α,α,α-trifluorotoluene 
• 349-50-8 (chlorodifluoromethyl)benzene 
• 98-56-6 4-chlorobenzotrifluoride 
• 98-15-7 3-chlorotrifluoromethylbenzene 

Downstream Products

• 196080-79-2 methylbenzene 
• 1494-20-8 2,2-difluoro-1,2-diphenylethan-1-ol 
• 339-30-0 2,2-difluoro-N-2-diphenylacetamide 
• 22235-32-1 [(difluorophenylmethyl)sulfanyl]benzene 
• 14595-76-7 α,α.α-tris(trimethylsilyl)toluene 

Relevant articles and documents

Selective electrochemical synthesis and reactivity of functional benzylic fluorosilylsynthons

Electrochemical reductive silylation of meta-(trifluoromethyl)arenes by the sacrificial anode technique selectively led to meta-trimethylsilyldifluoromethylarenes (ArCF2TMS), in the presence of an excess of TMSCl and in a THF/cosolvent mixture

Mg-Cu bimetal system for selective C-F bond activation

Bimetal system of Mg-CuCl in DMI for selective C-F and C-Cl bonds activation has been examined. This article involves (1) a short overview of bimetal system of Mg-metals for selective C-F bond activation, (2) C-F bond activation of alkyl trifluoroacetates

Cu-deposits on Mg metal surfaces promote electron transfer reactions

The enhancement of the electron transfer processes in the Grignard reagent formation-type ring silylation and the defluorination-silylation of perfluoroalkyl benzenes by Cu(0)-deposited Mg metal were confirmed. Microscopic analysis and substituent effects implied a different reduction process in the presence of Cu-deposited Mg metal than in the presence of bare Mg metal.

Preparation of (phenyldifluoromethyl)- and (phenoxydifluoromethyl)-silanes by magnesium-promoted carbon-chlorine bond activation

Treatment of α-chloro-α,α-difluorotoluene and α-chloro-α,α-difluoroanisole with chlorotrimethylsilane in the presence of magnesium in DMF led to their corresponding trimethylsilyl derivatives. These compounds are able to transfer their fluorinated group to various electrophilic substrates (carbonyl compounds, disulfides, phenyl isocyanate).

Selective electrosynthesis of (trimethylsilyldifluoro)methylbenzene, a PhCF2-precursor; conditions for a molar scale preparation without HMPA

Electrochemical reductive silylation of trifluoromethylbenzene by the sacrificial anode technique selectively led, in a THF/DMPU mixture instead of THF/HMPA and according to the charge passed, to the corresponding mono-, bis- or tris-trimethylsilyl derivatives, respectively PhCF2TMS, PhCF(TMS)2 and PhC(TMS)3. This reaction, without any chemical equivalent, was extended to a molar scale synthesis, using a tubular flow cell.

Nucleophilic introduction of fluorinated alkyl groups into aldehydes and ketones using the corresponding alkyl halide with samarium(II) iodide

Fluorinated alkyl groups such as PhCF2, C6F13, CF3CCl2 and CF2CO2Et are nucleophilically introduced into an aldehyde or ketone using fluorinated alkyl halides with SmI2/sub