339-30-0

Upstream product

• 103-71-9 phenyl isocyanate 
• 149021-01-2 (difluoro(trimethylsilyl)methyl)benzene 
• 2002-72-4 α,α-difluorobenzeneacetonitrile 
• 360-03-2 2,2-Difluoro-2-phenylacetic acid 
• 62-53-3 aniline 
• 103-80-0 phenylacetyl chloride 
• 127427-45-6 2-bromo-2,2-difluoro-N-phenyl-acetamide 
• 98-80-6 phenylboronic acid 
• 71-43-2 benzene 
• 28557-00-8 phenylzinc chloride 
• 1678-25-7 N-phenylbenzenesulfonamide 
• 383-19-7 2,2-difluoro-2-phenylacetamide 
• 40626-45-7 α,α-dichlorobenzylcyanide 
• 349-50-8 (chlorodifluoromethyl)benzene 

Relevant academic research and scientific papers

Visible Light-Induced Radical Rearrangement to Construct C-C Bonds via an Intramolecular Aryl Migration/Desulfonylation Process

A highly efficient intramolecular selective aryl migration/desulfonylation of 2-bromo-N-aryl-N-(arenesulfonyl)amide via visible light-induced photoredox catalysis has been accomplished. This approach allows for the construction of a variety of multisubstituted N,2-diarylacetamide under mild reaction conditions.

Nickel-Catalyzed Negishi Cross-Coupling of Bromodifluoroacetamides

A nickel-catalyzed Negishi coupling of bromodifluoroacetamides with arylzinc reagents has been developed. This reaction allows access to difluoromethylated aromatic compounds containing a variety of aryl groups and amide moieties. Furthermore, highly effe

Visible-light-driven difluoroacetamidation of unactive arenes and heteroarenes by direct C-H functionalization at room temperature

The directed difluoroacetamidation of unactivated arenes and heteroarenes with bromodifluoroacetamides via visible-light photoredox catalysis has been efficiently achieved at room temperature. Broad utility of this transformation is presented, including e

Nickel-catalyzed cross-coupling of functionalized difluoromethyl bromides and chlorides with aryl boronic acids: A general method for difluoroalkylated arenes

Transition-metal-catalyzed difluoroalkylation of aromatics remains challenging despite the importance of difluoroalkylated arenes in medicinal chemistry. Herein, the first successful example of nickel-catalyzed difluoroalkylation of aryl boronic acids is described. The reaction allows access to a variety of functionalized difluoromethyl bromides and chlorides, and paves the way to highly cost-efficient synthesis of a wide range of difluoroalkylated arenes. The notable features of this protocol are its high generality, excellent functional-group compatibility, low-cost nickel-catalyst, and practicality for gram-scale production, thus providing a facile method for applications in drug discovery and development.

Tricomponent catalytic α,α-difluorination of acid chlorides

The selective α,α-difluorination of carbonyl compounds remains a challenge in modern organic synthesis; current methods often incorporate stepwise processes and/or harsh conditions, providing unsatisfactory mixtures of mono- and difluorinated products. In this communication, a practical, mild, and one-pot method for the selective α,α-difluorination of readily available acid chlorides is reported in which three separate catalysts act synergistically to form products in outstanding selectivity and fair to excellent yields.

Preparation of (phenyldifluoromethyl)- and (phenoxydifluoromethyl)-silanes by magnesium-promoted carbon-chlorine bond activation

Treatment of α-chloro-α,α-difluorotoluene and α-chloro-α,α-difluoroanisole with chlorotrimethylsilane in the presence of magnesium in DMF led to their corresponding trimethylsilyl derivatives. These compounds are able to transfer their fluorinated group to various electrophilic substrates (carbonyl compounds, disulfides, phenyl isocyanate).