22235-32-1

Upstream product

• 7695-69-4 bis(phenylthio)methylbenzene 
• 349-50-8 (chlorodifluoromethyl)benzene 
• 930-69-8 sodium thiophenolate 
• 882-33-7 diphenyldisulfane 
• 149021-01-2 (difluoro(trimethylsilyl)methyl)benzene 
• 3111-52-2 potassium thiophenolate 
• 108-98-5 thiophenol 
• 455-31-2 difluoromethylbenzene 
• 2785-29-7 benzyl potassium 
• 83170-17-6 a-bromo-a,a-difluorotoluene 
• 100-52-7 benzaldehyde 

Downstream Products

• 22235-33-2 Phenyl-<α,α-difluor-benzyl>-sulfid 

Relevant academic research and scientific papers

DIFLUOROMETHYL AND DIFLUOROMETHYLENE TRANSFER REAGENTS

Disclosed herein are borazine, borate, and azaborinine compounds and compositions, methods of making said compounds and compositions, and methods of forming aromatic difluorocarbon compounds and difluorocarbon compounds.

The Difluoromethyl Group as a Masked Nucleophile: A Lewis Acid/Base Approach

The difluoromethyl group (R-CF2H) imparts desirable pharmacokinetic properties to drug molecules and is commonly targeted as a terminal functional group that is not amenable to further modification. Deprotonation of widely available Ar-CF2

Reactions of (chlorodifluoromethyl)benzene and (chlorodifluoromethoxy) benzene with nucleophilic reagents

Condensation reactions of (chlorodifluoromethyl)benzene and (chlorodifluoromethoxy)benzene with phenoxide and thiophenoxide ions have been performed in DMF or NMP with heating. In these conditions, the reaction between phenylselenide ion and (chlorodifluo

Preparation of (phenyldifluoromethyl)- and (phenoxydifluoromethyl)-silanes by magnesium-promoted carbon-chlorine bond activation

Treatment of α-chloro-α,α-difluorotoluene and α-chloro-α,α-difluoroanisole with chlorotrimethylsilane in the presence of magnesium in DMF led to their corresponding trimethylsilyl derivatives. These compounds are able to transfer their fluorinated group to various electrophilic substrates (carbonyl compounds, disulfides, phenyl isocyanate).

Anodic gem-Difluorination of Dithioacetals

Anodic desulfurization of dithioacetals of ketones in the presence of Et3N*3HF provided the corresponding gem-difluorocompounds while dithioacetals of aromatic and aliphatic aldehydes gave gem-difluorothioethers and monofluoro thioether, respectively.

Syntheses of New Aromatic Compounds with Fluorinated Side Chains and their Chemical Reactivity

The syntheses of a wide range of aromatic compounds of the type p-Y-C6H4CF2X(4-13) are described, and the chemical behavior of these compounds as a function of substituent Y is investigated .Analogously the pyridine derivatives 15, 17, and 18 were synthesized and characterized.From a correlation of the 19F-NMR data of these compounds with the Hammett constant of Y, participation of C-F ?-back-donation is seen as the cause for an observed shift of the 19F signals to lower field.