14908-53-3Relevant academic research and scientific papers
One-pot reduction of carboxylic acids via O-acylisoureas
Herbert, John M.,Hewson, Alan T.,Peace, James E.
, p. 823 - 832 (1998)
A simple one-pot reduction of aliphatic carboxylic acids to primary alcohols, by treatment with dicyclohexylcarbodiimide followed by lithium borohydride, is reported. The same methodology applied to aromatic carboxylic acids is shown to give a mixture of the alcohols with N- cyclohexylcarboxamides.
Some reactions of 2-(4-substitutedphenyl)-2-(N-methyl-N-4-substitutedbenzamido) acetic acids
Dürüst, Ya?ar,Karaku?, Hamza,Kariuki, Benson M.,Knight, David W.
, p. 2206 - 2220 (2018/07/15)
In situ generated 2,4-diaryl substituted münchnones from 2-(4-substitutedphenyl)-2-(N-methyl-N-4-substitutedbenzamido)acetic acids react with acetic anhydride in the presence of 2-nitromethylene thiazolidine, which is most likely acting as a base, and une
Synthesis of stable 1H-azirines reinvestigated: A structural corrigendum
Banert, Klaus,Hagedorn, Manfred,Peisker, Heiko
supporting information, p. 2943 - 2946 (2013/02/25)
The isoquinoline-catalyzed synthesis of pretended 1H-azirines from phenacyl bromides and N,N-dialkylcarbodiimides was repeated. The products do not possess the structure of antiaromatic 1H-azirines, but simple N-acyl-N,N-dialkylureas were formed instead. This structural corrigendum was confirmed by the independent synthesis of the known ureas and comparison of their 1H NMR and 13C NMR spectroscopic data in the case of six compounds. Thus, 1H-azirines keep their classification as very short-lived intermediates. Georg Thieme Verlag KG · Stuttgart · New York.
2-thiophenecarbohydrazides: A novel efficient method for the synthesis of 2-thiophenecarbohydrazide
Elshaarawy, Reda F.M.,Janiakb, Christoph
experimental part, p. 1202 - 1208 (2012/03/09)
Hydrazinolysis of carboxylic acid esters in alcoholic solutions is the standard method for preparing carbohydrazides (carboxylic hydrazides). Here we report an efficient process, involving the reaction of activated esters or amides with hydrazine, for the preparation of thiophenecarbohydrazides in yields larger than 90% and high purity. With this new method, a series of heteroaryl-, aryl-, or aralkyl- substituted carbohydrazides were synthesized and characterized. The X-ray crystal structure of 2-thiophenecarbohydrazide (thiophene-2-carboxylic hydrazide, 2-thenoyl-hydrazine) has revealed that it crystallizes in the monoclinic system, space group P21/c, with cell parameters of a = 6.1202(2), b = 8.3907(3), c = 12.5332(5) A, β = 98.6577(11)?, Z = 4, R(F) = 0.0455 and wR(F2) = 0.1805, T = 293 K.
Formation of N-acyl-N,N'-dicyclohexylureas from DCC and arenecarboxylic acids in the presence of hydroxybenzotriazole in CH2CI2 at room temperature
Kaiser, Carlos R.,Pinheiro, Alessandra C.,De Souza, Marcus V. N.,Wardell, James L.,Wardell, Solange M.S.V.
experimental part, p. 468 - 472 (2009/08/15)
The syntheses of N-acyl-N',N'-dicyclohexylureas from 1,3- dicyclohexylcarbodiimide and arenecarboxylic acids [p-XC6H 4CO2H (X = H or NO2), 2-, 3- or 4-pyridinecarboxylic acid and pyrazinecarboxylic acid] in the
Substituent effect in reaction of dicyclohexylcarbodiimide with substituted benzoic acids
Slebioda, Marek
, p. 7829 - 7834 (2007/10/02)
A curved Hammett relationship was observed for the reaction of substituted benzoic acids with dicyclohexylcarbodiimide in buffered solution. The reaction is promoted by electron-withdrawing substituents because of larger concentration of the acid anion pr
