One-pot reduction of carboxylic acids via O-acylisoureas

Article abstract of DOI:10.1080/00032719808006479

A simple one-pot reduction of aliphatic carboxylic acids to primary alcohols, by treatment with dicyclohexylcarbodiimide followed by lithium borohydride, is reported. The same methodology applied to aromatic carboxylic acids is shown to give a mixture of the alcohols with N- cyclohexylcarboxamides.

Full text of DOI:10.1080/00032719808006479

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Synthetic Communications:
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One-Pot Reduction of
Carboxylic Acids via O-
Acylisoureas
John M. Herbert a , Alan T. Hewson b & James E.
Peace b
a Isotope Chemistry Laboratories, Department
of Preclinical Metabolism and Pharmacokinetics,
Sanofi Research, Willowburn Ave, Alnwick,
Northumberland, NE66 2JH, U.K.
b Division of Chemistry and Health Research
Institute, Sheffield-Hallam University, Pond St.,
Sheffield, S1 1WB, U.K.
Published online: 20 Aug 2006.
To cite this article: John M. Herbert , Alan T. Hewson & James E. Peace
(1998): One-Pot Reduction of Carboxylic Acids via O-Acylisoureas, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 28:5, 823-832
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